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Thinking and practice of accelerating transformation of traditional Chinese medicine from experiencemedicine to evidence-based medicine

Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 163-170 doi: 10.1007/s11684-011-0143-9

Abstract: The gradual development of Chinese medicine is based on constant accumulation and summary of experience, with the development of evidence-based medicine, the bondage of the research methods of experienceThe rapid transition and transformation from experience medicine to evidence-based medicine have becometwo ways simultaneously” and complementing each other, continuously produce scientific and reliable evidenceof Chinese medicine, as well as transform and develop Chinese medicine from experience medicine to evidence-based

Keywords： Chinese medicine     experience medicine     evidence-based medicine     real world    

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Clinical research of traditional Chinese medicine in big data era

Junhua Zhang,Boli Zhang

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 321-327 doi: 10.1007/s11684-014-0370-y

Abstract: Data-intensive scientific discovery based on big data, named “The Fourth Paradigm,” has becomethe defects and weakness may be overcome in the methodology of the conventional clinical evaluation basedpreventive healthcare and symptom pattern differentiation for treatment in terms of traditional Chinese medicine

Keywords： big data     traditional Chinese medicine     clinical evaluation     evidence based medicine    

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Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies

Guangbiao Zhou, Saijuan Chen, Zhu Chen

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 117-125 doi: 10.1007/s11684-020-0773-x

Abstract: Since the outbreak of the COVID-19 pandemic in early December 2019, 81 174 confirmed cases and 3242 deaths have been reported in China as of March 19, 2020. The Chinese people and government have contributed huge efforts to combat this disease, resulting in significant improvement of the situation, with 58 new cases (34 were imported cases) and 11 new deaths reported on March 19, 2020. However, as of March 19, 2020, the COVID-19 pandemic continues to develop in 167 countries/territories outside of China, and 128 665 confirmed cases and 5536 deaths have been reported, with 16 498 new cases and 817 new deaths occurring in last 24 hours. Therefore, the world should work together to fight against this pandemic. Here, we review the recent advances in COVID-19, including the insights in the virus, the responses of the host cells, the cytokine release syndrome, and the therapeutic approaches to inhibit the virus and alleviate the cytokine storm. By sharing knowledge and deepening our understanding of the virus and the disease pathogenesis, we believe that the community can efficiently develop effective vaccines and drugs, and the mankind will eventually win this battle against this pandemic.

Keywords： COVID-19     SARS-CoV-2     pathogenesis     evidence-based medicine     control and therapeutic strategies    

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Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine

Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 157-162 doi: 10.1007/s11684-011-0128-8

Abstract: study, the authors introduced basic concepts and explored the application of the clinical pathway of evidence-basedChinese medicine incorporated with the methodology from the concepts of management, evidence-based medicineconcepts provide examples and experiences, on which the application of clinical pathway in Chinese medicinepractice in China can be based.

Keywords： evidence-based medicine     clinical pathway     methodology     concept     technical difficulty    

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Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19

Frontiers of Medicine doi: 10.1007/s11684-023-1040-8

Abstract: Traditional Chinese medicine (TCM) has played an important role in the prevention and treatment of coronavirusThe integration of Chinese and Western medicine is an important feature of Chinese COVID-19 preventionAccording to a series of evidence-based studies, TCM can reduce the infection rate of severe acute respiratory

Keywords： traditional Chinese medicine     COVID-19     SARS-CoV-2     clinical evidence-based study     mechanism     integratedtraditional Chinese and Western medicine    

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Traditional Chinese Medicine as a Treatment for Rheumatoid Arthritis: From Empirical Practice to Evidence-Based Review

Hu-Dan Pan, Yao Xiao, Wan-Ying Wang, Ru-Tong Ren, Elaine Lai-Han Leung , Liang Liu

Engineering 2019, Volume 5, Issue 5,   Pages 895-906 doi: 10.1016/j.eng.2019.01.018

Abstract: Traditional Chinese medicine (TCM) has long been used in China as a treatment for RA and is achievingTCM treatments are traditionally guided by the theory of treatment based on TCM syndrome differentiationResearchers should also collaborate to advance TCM from empirical practice to evidence-based therapy,

Keywords： Traditional Chinese medicine     Rheumatoid arthritis     Evidence-based therapy     Perspective    

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Translating evidence into policy in China: opportunities and challenges

Jiyao Wang, Xuejuan Jin

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 315-320 doi: 10.1007/s11684-011-0146-6

Abstract: Research and evidence are critical for the formulation of policies and practices in support of healthIn the past two decades, the Chinese Clinical Epidemiology Network has been promoting evidence-basedEvidence-based policy has become a major part of the government’s approach to policy making.The current article addresses the translation of evidence into health policies based on the expansionof evidence-based medicine in China.

Keywords： clinical epidemiology     evidence-based decision making     policy    

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Development Strategy of Chinese and Western Integrative Medicine Under New Circumstances

Wang Conghui, Feng Zhe, Yin Zhiwei, Li Shuang, Chen Xiangmei

Strategic Study of CAE 2021, Volume 23, Issue 2,   Pages 169-174 doi: 10.15302/J-SSCAE-2021.02.016

Abstract: The Chinese and western integrative medicine, a unique medical model in China, has played an importantFirst, we review the achievements of the Chinese and western integrative medicine since 1949 using literaturereview and questionnaire survey, and summarize the key roles of this integrative medicine in the preventionSubsequently, we analyze the weaknesses of the integrative medicine in terms of medical resources, clinicaland a world-leading role in the integration of Chinese traditional medicine with western medicine.

Keywords： Chinese and western integrative medicine     evidence-based medicine     evaluation system     talent training    

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Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known

Jiabo Wang,Zhijie Ma,Ming Niu,Yun Zhu,Qingsheng Liang,Yanling Zhao,Jingyuan Song,Zhaofang Bai,Yaming Zhang,Ping Zhang,Na Li,Yakun Meng,Qi Li,Lushan Qin,Guangju Teng,Junling Cao,Baosen Li,Shilin Chen,Yonggang Li,Zhengsheng Zou,Honghao Zhou,Xiaohe Xiao

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 457-467 doi: 10.1007/s11684-015-0417-8

Abstract: previously incorrectly attributed and a case that was excluded from Heshouwu causality by pharmacognostic evidence

Keywords： drug-induced liver injury     pharmacognosy     metabolomics     stilbene     Polygonum multiflorum     Chinese herbal medicine    

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Multi-stage emergency medicine logistics system optimization based on survival probability

Ke WANG, Yixin LIANG, Lindu ZHAO

Frontiers of Engineering Management 2017, Volume 4, Issue 2,   Pages 221-228 doi: 10.15302/J-FEM-2017020

Abstract: arrival probability over time are discussed, a formula is proposed for maximum possible survival rate based

Keywords： emergency medicine logistics     ambulance drone     survival probability     critical illness    

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New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 17-24 doi: 10.1007/s11684-021-0873-2

Abstract: This review summarizes clinical evidence of the semaglutide effect on T2D and obesity and establishes

Keywords： semaglutide     type 2 diabetes     obesity    

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Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 736-744 doi: 10.1007/s11684-021-0870-5

Abstract: Traditional Chinese medicine (TCM) presents a favorable prospect in the treatment of pneumoconiosis.

Keywords： pneumoconiosis     randomized controlled trials     traditional Chinese medicine    

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Genetic evidence in planar cell polarity signaling pathway in human neural tube defects

Chunquan Cai, Ouyan Shi

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 68-78 doi: 10.1007/s11684-014-0308-4

Abstract:

Neural tube defects (NTDs) are a group of birth anomalies having a profound physical, emotional, and financial effects on families and communities. Their etiology is complex, involving environmental and genetic factors that interact to modulate the incidence and severity of the developing phenotype. The planar cell polarity (PCP) pathway controls the process of convergent extension (CE) during gastrulation and neural tube closure and has been implicated in the pathogenesis of NTDs in animal models and human cohorts. This review summarizes the cumulative results of recent studies on PCP signaling pathway and human NTDs. These results demonstrate that PCP gene alterations contribute to the etiology of human NTDs.

Keywords： planar cell polarity     neural tube defects     rare mutations    

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From SARS to MERS: evidence and speculation

Hainv Gao,Hangping Yao,Shigui Yang,Lanjuan Li

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 377-382 doi: 10.1007/s11684-016-0466-7

Abstract:

The Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic pathogen. In 2012, the infectious outbreak caused by MERS-CoV in Saudi Arabia has spread to more than 1600 patients in 26 countries, resulting in over 600 deaths. Without a travel history, few clinical and radiological features can reliably differentiate MERS from SARS. But in real world, comparing with SARS, MERS presents more vaguely defined epidemiology, more severe symptoms, and higher case fatality rate. In this review, we summarize the recent findings in the field of MERS-CoV, especially its molecular virology, interspecies mechanisms, clinical features, antiviral therapies, and the further investigation into this disease. As a newly emerging virus, many questions are not fully answered, including the exact mode of transmission chain, geographical distribution, and animal origins. Furthermore, a new protocol needs to be launched to rapidly evaluate the effects of unproven antiviral drugs and vaccine to fasten the clinical application of new drugs.

Keywords： middle east respiratory syndrome     animal origin     cross-species transmission     monoclonal antibody    

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Electricity demand, GDP and employment: evidence from Italy

Cosimo MAGAZZINO

Frontiers in Energy 2014, Volume 8, Issue 1,   Pages 31-40 doi: 10.1007/s11708-014-0296-8

Abstract: This paper applies time series methodologies to examine the causal relationship among electricity demand, real per capita GDP and total labor force for Italy from 1970 to 2009. After a brief introduction, a survey of the economic literature on this issue is reported, before discussing the data and introducing the econometric techniques used. The results of estimation indicate that one cointegrating relationship exists among these variables. This equilibrium relation implies that, in the long-run, GDP and labor force are correlated negatively, as well as GDP and electricity. Moreover, there is a bi-directional Granger causality flow between real per capita GDP and electricity demand; while labor force does not Granger-cause neither real per capita GDP nor electricity demand. This implies that electricity demand and economic growth are jointly determined at the same time for the Italian case. The forecast error variance decomposition shows that forecast errors in real per capita GDP are mainly caused by the uncertainty in GDP itself, while forecast errors in labor force are mainly resulted from the labor force itself, although aggregate income and electricity are important, too.

Keywords： energy policies     electricity demand     GDP     labor force     stationarity     structural breaks     cointegration     causality     Italy    

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Title Author Date Type Operation

Thinking and practice of accelerating transformation of traditional Chinese medicine from experiencemedicine to evidence-based medicine

Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou

Journal Article

Clinical research of traditional Chinese medicine in big data era

Junhua Zhang,Boli Zhang

Journal Article

Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies

Guangbiao Zhou, Saijuan Chen, Zhu Chen

Journal Article

Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine

Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu

Journal Article

Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19

Journal Article

Traditional Chinese Medicine as a Treatment for Rheumatoid Arthritis: From Empirical Practice to Evidence-Based

Hu-Dan Pan, Yao Xiao, Wan-Ying Wang, Ru-Tong Ren, Elaine Lai-Han Leung , Liang Liu

Journal Article

Translating evidence into policy in China: opportunities and challenges

Jiyao Wang, Xuejuan Jin

Journal Article

Development Strategy of Chinese and Western Integrative Medicine Under New Circumstances

Wang Conghui, Feng Zhe, Yin Zhiwei, Li Shuang, Chen Xiangmei

Journal Article

Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known

Jiabo Wang,Zhijie Ma,Ming Niu,Yun Zhu,Qingsheng Liang,Yanling Zhao,Jingyuan Song,Zhaofang Bai,Yaming Zhang,Ping Zhang,Na Li,Yakun Meng,Qi Li,Lushan Qin,Guangju Teng,Junling Cao,Baosen Li,Shilin Chen,Yonggang Li,Zhengsheng Zou,Honghao Zhou,Xiaohe Xiao

Journal Article

Multi-stage emergency medicine logistics system optimization based on survival probability

Ke WANG, Yixin LIANG, Lindu ZHAO

Journal Article

New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

Journal Article

Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients

Journal Article

Genetic evidence in planar cell polarity signaling pathway in human neural tube defects

Chunquan Cai, Ouyan Shi

Journal Article

From SARS to MERS: evidence and speculation

Hainv Gao,Hangping Yao,Shigui Yang,Lanjuan Li

Journal Article

Electricity demand, GDP and employment: evidence from Italy

Cosimo MAGAZZINO

Journal Article