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Genomics and genetic breeding in aquatic animals: progress and prospects

Wenteng XU, Songlin CHEN

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3, Pages 305-318 doi: 10.15302/J-FASE-2017154

Abstract: Genomics focuses on dissection of genome structure and function to provide a molecular basis for understanding

Keywords： aquaculture genomics genetic breeding progress

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Sepsis biomarkers: an omics perspective

Xiao Liu, Hui Ren, Daizhi Peng

Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 58-67 doi: 10.1007/s11684-014-0318-2

Abstract: This review describes currently available and novel sepsis biomarkers in the context of genomics, transcriptomics

Keywords： sepsis biomarker genomics transcriptomics proteomics metabolomics

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An introduction to the medicinal plant genome project

Shilin Chen, Li Xiang, Xu Guo, Qiushi Li

Frontiers of Medicine 2011, Volume 5, Issue 2, Pages 178-184 doi: 10.1007/s11684-011-0131-0

Abstract: In recent years, genomics has developed rapidly with the application of next-generation sequencing technologyHowever, very few studies have been carried out on genomics for medicinal plants.genome research of medicinal plants, including genome sequencing, assembly, annotation, and functional genomics

Keywords： genomics medicinal plant sequencing application

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Do not let precision medicine be kidnapped

Zhiping Yang

Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 512-513 doi: 10.1007/s11684-015-0425-8

Abstract:

Obama’s precision medicine initiative made the medical community boil over after the initiative’s release. Precision medicine has been advocated by the majority of scientists and doctors. However, some experts have questioned this concept. This article does not oppose precision medicine. However, the incentive of vigorously promoting precision medicine at present is a concern.

Keywords： precision medicine personalized medicine genomics

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Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia

Ching-Hon Pui

Frontiers of Medicine 2015, Volume 9, Issue 1, Pages 1-9 doi: 10.1007/s11684-015-0381-3

Abstract:

With the cure rate of childhood acute lymphoblastic leukemia (ALL) approaching 90%, further improvement in the treatment outcome and quality of life of patients will require better understanding of the mechanisms of drug resistance, identifying new leukemic cell genetic lesions that are amendable to available target therapy, and optimizing treatment based on host pharmacodynamics and pharmacogenomics. Deeper characterization of leukemic cell genetic abnormalities has discovered new subtypes of leukemia such as early T-cell precursor ALL and Philadelphia chromosome-like ALL, and identified many genomic alterations that have diagnostic, prognostic, or therapeutic implications. In this regard, several novel fusion transcripts are responsive to ABL tyrosine kinase inhibitors and potentially to JAK inhibitors. Genome-wide analyses have also unraveled the role of inherited cancer predisposing genes and small nucleotide polymorphisms of several genes in the development of childhood ALL. These advances promise to lead to more sophisticated personalized treatment strategies in the near future.

Keywords： pharmacogenomics acute lymphoblastic leukemia genomics pharmacogenetics

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Genomics approaches to unlock the high yield potential of cassava, a tropical model plant

Shengkui ZHANG,Ping’an MA,Haiyan WANG,Cheng LU,Xin CHEN,Zhiqiang XIA,Meiling ZOU,Xinchen ZHOU,Wenquan WANG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4, Pages 259-266 doi: 10.15302/J-FASE-2014043

Abstract: However, the understanding of the metabolism and genomics of this important crop is limited.The recent breakthroughs in the genomics of cassava, including whole-genome sequencing and transcriptome

Keywords： cassava genomics yield potential adaptability tropical model

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Recent advances in fruit crop genomics

Qiang XU,Chaoyang LIU,Manosh Kumar BISWAS,Zhiyong PAN,Xiuxin DENG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1, Pages 21-27 doi: 10.15302/J-FASE-2014002

Abstract: In recent years, dramatic progress has been made in the genomics of fruit crops.The publication of a dozen fruit crop genomes represents a milestone for both functional genomics andRapid advances in high-throughput sequencing technology have revolutionized the manner and scale of genomics

Keywords： fruit crops fruit biology gene function genomics

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Core Metabolic Features and Hot Origin of Bathyarchaeota Article

Xiaoyuan Feng, Yinzhao Wang, Rahul Zubin, Fengping Wang

Engineering 2019, Volume 5, Issue 3, Pages 498-504 doi: 10.1016/j.eng.2019.01.011

Abstract:

The archaeal phylum Bathyarchaeota comprises highly diversified subgroups and is considered to be one of the most abundant microorganisms on earth. The metabolic features and evolution of this phylum still remain largely unknown. In this article, a comparative metabolic analysis of 15 newly reconstructed and 36 published metagenomic assembled genomes (MAGs) spanning 10 subgroups was performed, revealing the core metabolic features of Bathyarchaeota—namely, protein, lipid, and benzoate degradation; glycolysis; and the Wood–Ljungdahl (WL) pathway, indicating an acetyl-CoA-centralized metabolism within this phylum. Furthermore, a partial tricarboxylic acid (TCA) cycle, acetogenesis, and sulfur-related metabolic pathways were found in specific subgroups, suggesting versatile metabolic capabilities and ecological functions of different subgroups. Intriguingly, most of the MAGs from the Bathy-21 and -22 subgroups, which are placed at the phylogenetic root of all bathyarchaeotal lineages and likely represent the ancient Bathyarchaeota types, were found in hydrothermal environments and encoded reverse gyrase, suggesting a hyperthermophilic feature. This work reveals the core metabolic features of Bathyarchaeota, and indicates a hot origin of this archaeal phylum.

Keywords： Bathyarchaeota Metagenomics Comparative genomics Hyperthermophilic adaptation

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10x Genomics单细胞转录组测序及多组学数据挖掘技术

Conference Date: 2 Aug 2019

Conference Place: 北京海淀区

Administered by: 北京市计算中心

Twelve Years of Genome-Wide Association Studies of Human Protein N-Glycosylation Review

Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko

Engineering 2023, Volume 26, Issue 7, Pages 17-31 doi: 10.1016/j.eng.2023.03.013

Abstract: can provide much sought-after knowledge of human in vivo glycobiology are human genetics and genomics

Keywords： Glycome Glycans N-glycosylation Genomics Genetics GWAS

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Neosporosis: An Overview of Its Molecular Epidemiology and Pathogenesis Review

Asis Khan, Jahangheer S. Shaik, Patricia Sikorski, Jitender P. Dubey, Michael E. Grigg

Engineering 2020, Volume 6, Issue 1, Pages 10-19 doi: 10.1016/j.eng.2019.02.010

Abstract: Hence, detailed population genomics studies based on wholegenome sequences from multiple strains worldwideThe aim of this review is to outline our current understanding of the molecular epidemiology and genomics

Keywords： Neosporosis Molecular epidemiology Population genetics Genomics Host response Vaccine