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Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi
Frontiers of Medicine 2016, Volume 10, Issue 3, Pages 311-319 doi: 10.1007/s11684-016-0460-0
We evaluated the roles of calpain cleavage-related mutations of the integrin β3 cytoplasmic tailin integrin αIIbβ3 bidirectional signaling using a trans-dominant inhibition model.consisting of the extracellular and transmembrane domains of human IL-2 receptor (Tac) and the human integrindomain were stably expressed in the 123 CHO cells harboring human glycoprotein Ib-IX and wild-type integrinIn conclusion, the calpain cleavage of integrin β3 resulted in the regulatory effects on signaling
Keywords: integrin β3 signal transduction trans-dominant inhibition model
Talin and kindlin: the one-two punch in integrin activation
Feng Ye, Adam K. Snider, Mark H. Ginsberg
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 6-16 doi: 10.1007/s11684-014-0317-3
Proper cell-cell and cell-matrix contacts mediated by integrin adhesion receptors are important forHere, we review how talin-integrin and kindlin-integrin interactions, in cooperation with talin-lipidand kindlin-lipid interactions, regulate integrin affinities and how the progress in these areas helpsus understand integrin-related diseases.
Keywords: signal transduction transmembrane domain nanodisc integrin talin kindling cell adhesion
Expression of integrin in hepatic fibrosis and intervention of resveratrol
Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN
Frontiers of Medicine 2009, Volume 3, Issue 1, Pages 100-107 doi: 10.1007/s11684-009-0013-x
Keywords: liver fibrosis integrin-β1 resveratrol tumor growth factor-β tissue inhibitor of metalloproteinase-1
Coronary leukocyte activation in relation to progression of coronary artery disease
Marijke A. de Vries,Arash Alipour,Erwin Birnie,Andrew Westzaan,Selvetta van Santen,Ellen van der Zwan,Anho H. Liem,Noëlle van der Meulen,Manuel Castro Cabezas
Frontiers of Medicine 2016, Volume 10, Issue 1, Pages 85-90 doi: 10.1007/s11684-016-0435-1
Leukocyte activation has been linked to atherogenesis, but there is little in vivo evidence for its role in the progression of atherosclerosis. We evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activation markers in the coronary circulation. Monocyte and neutrophil CD11b, neutrophil CD66b expression and intracellular neutrophil myeloperoxidase (MPO) in the coronary arteries were determined by flow cytometry in patients undergoing coronary angiography. The primary outcome included fatal and nonfatal myocardial infarction or arterial vascular intervention due to unstable angina pectoris. In total 99 subjects who were included, 70 had CAD at inclusion (26 patients had single-vessel disease, 18 patients had two-vessel disease and 26 patients had three-vessel disease). The median follow-up duration was 2242 days (interquartile range: 2142–2358). During follow-up, 13 patients (13%) developed progression of CAD. Monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO measured in blood obtained from the coronary arteries were not associated with the progression of CAD. These data indicate that coronary monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO do not predict the risk of progression of CAD.
Keywords: coronary artery disease inflammation integrin myeloperoxidase leukocyte activation
Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang
Engineering 2021, Volume 7, Issue 10, Pages 1415-1425 doi: 10.1016/j.eng.2020.08.013
Keywords: Pancreatic cancer Organotropic metastasis Exosomes Pre-metastatic niche CD44
Title Author Date Type Operation
Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition
Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi
Journal Article
Talin and kindlin: the one-two punch in integrin activation
Feng Ye, Adam K. Snider, Mark H. Ginsberg
Journal Article
Expression of integrin in hepatic fibrosis and intervention of resveratrol
Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN
Journal Article
Coronary leukocyte activation in relation to progression of coronary artery disease
Marijke A. de Vries,Arash Alipour,Erwin Birnie,Andrew Westzaan,Selvetta van Santen,Ellen van der Zwan,Anho H. Liem,Noëlle van der Meulen,Manuel Castro Cabezas
Journal Article