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Journal Article 5

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integrin 2

signal transduction 2

CD44 1

Exosomes 1

Organotropic metastasis 1

Pancreatic cancer 1

Pre-metastatic niche 1

cell adhesion 1

coronary artery disease 1

inflammation 1

integrin β3 1

integrin-β1 1

kindling 1

leukocyte activation 1

liver fibrosis 1

myeloperoxidase 1

nanodisc 1

resveratrol 1

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Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition

Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 311-319 doi: 10.1007/s11684-016-0460-0

Abstract:

We evaluated the roles of calpain cleavage-related mutations of the integrin β3 cytoplasmic tailin integrin αIIbβ3 bidirectional signaling using a trans-dominant inhibition model.consisting of the extracellular and transmembrane domains of human IL-2 receptor (Tac) and the human integrindomain were stably expressed in the 123 CHO cells harboring human glycoprotein Ib-IX and wild-type integrinIn conclusion, the calpain cleavage of integrin β3 resulted in the regulatory effects on signaling

Keywords: integrin β3     signal transduction     trans-dominant inhibition model    

Talin and kindlin: the one-two punch in integrin activation

Feng Ye, Adam K. Snider, Mark H. Ginsberg

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 6-16 doi: 10.1007/s11684-014-0317-3

Abstract:

Proper cell-cell and cell-matrix contacts mediated by integrin adhesion receptors are important forHere, we review how talin-integrin and kindlin-integrin interactions, in cooperation with talin-lipidand kindlin-lipid interactions, regulate integrin affinities and how the progress in these areas helpsus understand integrin-related diseases.

Keywords: signal transduction     transmembrane domain     nanodisc     integrin     talin     kindling     cell adhesion    

Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 100-107 doi: 10.1007/s11684-009-0013-x

Abstract: The aim of this study was to explore the expression of integrin-β1 in different stages of hepatic fibrosisand intervention of resveratrol as well as the way by which integrin-β1 promoted hepatic fibrosis.The expression of integrin-β1, tumor growth factor-β (TGF-β) and tissue inhibitor of metalloproteinaseThe expression of integrin-β1, TGF-β and TIMP-1 was determined in each group.The expression of integrin-β1 in normal control group was low and steady and was not increased as the

Keywords: liver fibrosis     integrin-β1     resveratrol     tumor growth factor-β     tissue inhibitor of metalloproteinase-1    

Coronary leukocyte activation in relation to progression of coronary artery disease

Marijke A. de Vries,Arash Alipour,Erwin Birnie,Andrew Westzaan,Selvetta van Santen,Ellen van der Zwan,Anho H. Liem,Noëlle van der Meulen,Manuel Castro Cabezas

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 85-90 doi: 10.1007/s11684-016-0435-1

Abstract:

Leukocyte activation has been linked to atherogenesis, but there is little in vivo evidence for its role in the progression of atherosclerosis. We evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activation markers in the coronary circulation. Monocyte and neutrophil CD11b, neutrophil CD66b expression and intracellular neutrophil myeloperoxidase (MPO) in the coronary arteries were determined by flow cytometry in patients undergoing coronary angiography. The primary outcome included fatal and nonfatal myocardial infarction or arterial vascular intervention due to unstable angina pectoris. In total 99 subjects who were included, 70 had CAD at inclusion (26 patients had single-vessel disease, 18 patients had two-vessel disease and 26 patients had three-vessel disease). The median follow-up duration was 2242 days (interquartile range: 2142–2358). During follow-up, 13 patients (13%) developed progression of CAD. Monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO measured in blood obtained from the coronary arteries were not associated with the progression of CAD. These data indicate that coronary monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO do not predict the risk of progression of CAD.

Keywords: coronary artery disease     inflammation     integrin     myeloperoxidase     leukocyte activation    

Exosomal CD44 Cooperates with Integrin α6β4 to Support Organotropic Metastasis via Regulating Tumor Cell Article

Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang

Engineering 2021, Volume 7, Issue 10,   Pages 1415-1425 doi: 10.1016/j.eng.2020.08.013

Abstract: Moreover, CD44 was found to interact with integrin α6β4 to form a complex, thereby remodeling

Keywords: Pancreatic cancer     Organotropic metastasis     Exosomes     Pre-metastatic niche     CD44    

Title Author Date Type Operation

Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition

Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi

Journal Article

Talin and kindlin: the one-two punch in integrin activation

Feng Ye, Adam K. Snider, Mark H. Ginsberg

Journal Article

Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Journal Article

Coronary leukocyte activation in relation to progression of coronary artery disease

Marijke A. de Vries,Arash Alipour,Erwin Birnie,Andrew Westzaan,Selvetta van Santen,Ellen van der Zwan,Anho H. Liem,Noëlle van der Meulen,Manuel Castro Cabezas

Journal Article

Exosomal CD44 Cooperates with Integrin α6β4 to Support Organotropic Metastasis via Regulating Tumor Cell

Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang

Journal Article