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γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 262-268 doi: 10.1007/s11684-017-0584-x

Abstract: γδ T cells are enriched in the liver and exhibit liver-specific features.fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regenerationWe believe that determining the properties and functions of γδ T cells in liver diseasesenhances our understanding of the pathogenesis of liver diseases and is useful for the design of novelγδ T cell-based therapeutic regimens for liver diseases.

Keywords： γδT cells     liver infection     non-alcoholic fatty liver disease     autoimmune hepatitis     liver fibrosis and cirrhosis     liver cancer     liver regeneration    

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Correlation between viral load and liver cirrhosis in chronic hepatitis B patients

Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 271-276 doi: 10.1007/s11684-009-0054-1

Abstract: the relationship between hepatitis B virus (HBV) DNA levels during the course and the progression to cirrhosisA total of 239 chronic hepatitis B patients confirmed by liver biopsy between 2001 and 2007 were followedCompared with the patients without cirrhosis, the patients progressed to cirrhosis were older and withHowever, there was no significant difference in cirrhosis progression between different HBV-DNA groupsThe results of Cox model indicated that HBV-DNA levels at endpoint, stage of fibrosis, negative hepatitis

Keywords： hepatitis B     chronic     viral load     liver cirrhosis    

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Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis

Frontiers of Medicine 2024, Volume 18, Issue 3,   Pages 538-557 doi: 10.1007/s11684-024-1079-1

Abstract: Schistosoma infection is one of the major causes of liver fibrosis.Emerging roles of hepatic progenitor cells (HPCs) in the pathogenesis of liver fibrosis have been identifiedNevertheless, the precise mechanism underlying the role of HPCs in liver fibrosis in schistosomiasisThis study examined how autophagy in HPCs affects schistosomiasis-induced liver fibrosis by modulatingBlocking autophagy by the autophagy inhibitor chloroquine (CQ) significantly diminished liver fibrosis

Keywords： schistosomiasis     hepatic progenitor cell     autophagy     extracellular vesicle     fibrosis     miRNA    

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Assessment of liver volume variation to evaluate liver function

Cong Tong, Xinsen Xu, Chang Liu, Tianzheng Zhang, Kai Qu

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 421-427 doi: 10.1007/s11684-012-0223-5

Abstract:

In order to assess the value of liver volumetry in cirrhosis and acute liver failure (ALF) patientsThe clinical data of 48 cirrhosis patients with 60 normal controls and 39 ALF patients were collectedThe hepatic volume of cirrhosis patients in Child A, B level was not reduced, but in Child C level itIn conclusion, the CTLV/SLV ratio, which reflects liver volume variations, correlates well with the liverfunction and progression of cirrhosis and ALF.

Keywords： liver volume variation     cirrhosis     acute liver failure (ALF)    

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Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 100-107 doi: 10.1007/s11684-009-0013-x

Abstract: The aim of this study was to explore the expression of integrin-β1 in different stages of hepatic fibrosisand intervention of resveratrol as well as the way by which integrin-β1 promoted hepatic fibrosis.Hepatic fibrosis models of male Sprague Dawley (SD) rats were created and intragastric administrationLiver function and pathological sections of each group in different stages of hepatic fibrosis was testedas the development of hepatic fibrosis.

Keywords： liver fibrosis     integrin-β1     resveratrol     tumor growth factor-β     tissue inhibitor of metalloproteinase-1    

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Serum N-Glycan Markers for Diagnosing Significant Liver Fibrosis and Cirrhosis in Chronic Hepatitis Article

Lin Wang, Yiqi Liu, Qixin Gu, Chi Zhang, Lei Xu, Lei Wang, Cuiying Chen, Xueen Liu, Hong Zhao, Hui Zhuang

Engineering 2023, Volume 26, Issue 7,   Pages 151-158 doi: 10.1016/j.eng.2023.03.008

Abstract: fibrosis and cirrhosis in 285 chronic hepatitis B (CHB) patients with normal (< 40 IU·LLiver biopsies were performed in all enrolled patients, and the stages of liver fibrosis were assessedfibrosis (≥ F3) and cirrhosis (≥ F5).liver fibrosis and cirrhosis, respectively, and 4.91% (14/285) of patients had significant inflammationIn distinguishing liver cirrhosis, the diagnostic AUROC curve of the serum N-glycan RF model

Keywords： Liver fibrosis     Chronic hepatitis B     Serum N-glycan     N-glycan model     Alanine aminotransferase    

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New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 714-722 doi: 10.1007/s11684-021-0888-8

Abstract: A new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) has recently been proposedWe aim to examine the associations of MAFLD, particularly its discordance from non-alcoholic fatty liverPatients with MAFLD with high value of hepamet fibrosis score or poor-controlled diabetes had higherwould be practical for the evaluation of long-term risk of subclinical atherosclerosis among fatty liver

Keywords： metabolic dysfunction-associated fatty liver disease     non-alcoholic fatty liver disease     fibrosis score    

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Characterization of the Gastric Mucosal Microbiota in Patients with Liver Cirrhosis and Its Associations Article

Yanfei Chen, Jing Guo, Chunlei Chen, Ding Shi, Daiqiong Fang, Feng Ji, Lanjuan Li

Engineering 2021, Volume 7, Issue 4,   Pages 507-514 doi: 10.1016/j.eng.2020.04.014

Abstract: Several studies have indicated that the oral and gut microbiota may exhibit differences in patients with cirrhosisIn this study, the gastric mucosal microbiota of patients with liver cirrhosis and controls were analyzedIn H. pylori-negative subjects, gastric bacterial communities of healthy and cirrhosis cohortssuggest that the colonization of both H. pylori and non-H. pylori is influenced in livercirrhosis.

Keywords： Microbiome     Liver cirrhosis     Symptoms     Varices     Gastric endoscopy    

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beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic CD14 expression in rats with liverfibrosis

Jianguo LIU, Zhe ZHANG, Jiechang GAO, Jiwen XIE, Lin YANG, Shenjun HU

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 101-105 doi: 10.1007/s11684-011-0111-4

Abstract: demonstrated that β-elemene could protect against carbon tetrachloride (CCl4)-induced liverfibrosis in our laboratory work, and the aim of this paper is to reveal the protective mechanisms ofThe hepatic fibrosis experimental model was induced by the hypodermical injection of CCl4&downregulate the levels of plasma endotoxins, serum TNF-α, and hepatic CD14 expression in rats with liverfibrosis.

Keywords： liver fibrosis     beta-elemene     endotoxin     CD14    

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Studies of the Guiyuan Fang and Autologous Bone Marrow Stem Cells Transplantation on Hepatic Injury and Fibrosis

Wu Limao,Li Lianda,Liu Hong,Ning Keyong,Li Yikui

Strategic Study of CAE 2004, Volume 6, Issue 7,   Pages 34-42

Abstract: Methods Acute localized liver injury model was induced in rabbits by injecting ethanol locally, and theliver fibrosis models were reproduced by complex factors (high lipid, low protein, alcohol, CClLiver function was assessed by measurement ALT, AST, TP, ALB, and GST.Histopathological changes and degrees of fibrosis, hydroxyproline content in the hepatic tissues wereparenchyma, along with expression of cytokeratin-18，the liver epithelial specific marker.

Keywords： bone marrow stem cells     autologous transplantation     liver injury     liver fibrosis     guiyuan fang    

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Therapeutic Targeting of PKM2 Ameliorates NASH Fibrosis Progression in A Macrophage-Specific and Liver-Specific Article

Hengdong Qu,Di Zhang,Junli Liu,Jieping Deng,Ruoyan Xie,Keke Zhang,Hongmei Li,Ping Tao,Genshu Wang,Jian Sun,Oscar Junhong Luo,Chen Qu,Wencai Ye,Jian Hong

Engineering 2024, Volume 41, Issue 10,   Pages 189-203 doi: 10.1016/j.eng.2024.05.005

Abstract: text-align: justify;">Nonalcoholic steatohepatitis (NASH) may soon become the leading cause of end-stage liverLiver fibrosis, which is driven by chronic inflammation and hepatic stellate cell (HSC) activation, criticallyits role and therapeutic potential in NASH-related fibrosis remain largely unexplored., dose-dependently reversed NASH-related fibrosis without causing observable hepatotoxicity.novel strategy to combat NASH-related fibrosis.

Keywords： kinase M2     Macrophages     nonparenchymal cells     heteroduplex oligonucleotide     Nonalcoholic steatohepatitis     Liverfibrosis    

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Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate cells

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 36-40 doi: 10.1007/s11684-009-0020-y

Abstract: expression of AT1R, which may be the mechanism by which β-elemene prevents the progress of hepatic fibrosis

Keywords： liver cirrhosis     beta-elemene     hepatic stellate cells     angiotensin II     receptor     angiotensin     type 1    

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Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 445-455 doi: 10.1007/s11684-014-0378-3

Abstract: Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failureThe purpose of this study was to investigate the effects of PDE5 inhibitor on cardiac fibrosis.We assessed cardiac fibrosis and pathology in mice subjected to transverse aortic constriction (TAC).In control mice, 4 weeks of TAC induced significant cardiac dysfunction, cardiac fibrosis, and cardiacSildenafil treatment markedly prevented TAC-induced cardiac dysfunction, cardiac fibrosis and cardiac

Keywords： PDE5     cardiac fibrosis     TGF-β     CREB    

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mA reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation

Frontiers of Medicine 2024, Volume 18, Issue 3,   Pages 499-515 doi: 10.1007/s11684-023-1052-4

Abstract: Cardiac fibrosis caused by ventricular remodeling and dysfunction such as post-myocardial infarctionIn investigating the biological function of the m6A reader YTHDF1 in cardiac fibrosis, adeno-associated(TGF-β)-activated cardiac fibroblasts in vitro were performed to establish fibrosisYTHDF1 in mouse hearts can significantly restore impaired cardiac function and attenuate myocardial fibrosisOur results revealed that YTHDF1 could serve as a potential therapeutic target for myocardial fibrosis

Keywords： cardiac fibrosis     YTHDF1     AXL     ZBED6     heart failure    

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Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on

Zhen Zhang, Na Jiang, Zhaohui Ni

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 349-358 doi: 10.1007/s11684-017-0571-2

Abstract: morphologic and functional changes to the peritoneal membrane (PM), which is defined as peritoneal fibrosisInflammation and angiogenesis are key events during the pathogenesis of peritoneal fibrosis.This review discusses the pathophysiology of peritoneal fibrosis and recent research progress on key

Keywords： peritoneal dialysis     peritoneal fibrosis     inflammation     angiogenesis    

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Title Author Date Type Operation

γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Journal Article

Correlation between viral load and liver cirrhosis in chronic hepatitis B patients

Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,

Journal Article

Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis

Journal Article

Assessment of liver volume variation to evaluate liver function

Cong Tong, Xinsen Xu, Chang Liu, Tianzheng Zhang, Kai Qu

Journal Article

Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Journal Article

Serum N-Glycan Markers for Diagnosing Significant Liver Fibrosis and Cirrhosis in Chronic Hepatitis

Lin Wang, Yiqi Liu, Qixin Gu, Chi Zhang, Lei Xu, Lei Wang, Cuiying Chen, Xueen Liu, Hong Zhao, Hui Zhuang

Journal Article

New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

Journal Article

Characterization of the Gastric Mucosal Microbiota in Patients with Liver Cirrhosis and Its Associations

Yanfei Chen, Jing Guo, Chunlei Chen, Ding Shi, Daiqiong Fang, Feng Ji, Lanjuan Li

Journal Article

beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic CD14 expression in rats with liverfibrosis

Jianguo LIU, Zhe ZHANG, Jiechang GAO, Jiwen XIE, Lin YANG, Shenjun HU

Journal Article

Studies of the Guiyuan Fang and Autologous Bone Marrow Stem Cells Transplantation on Hepatic Injury and Fibrosis

Wu Limao,Li Lianda,Liu Hong,Ning Keyong,Li Yikui

Journal Article

Therapeutic Targeting of PKM2 Ameliorates NASH Fibrosis Progression in A Macrophage-Specific and Liver-Specific

Hengdong Qu,Di Zhang,Junli Liu,Jieping Deng,Ruoyan Xie,Keke Zhang,Hongmei Li,Ping Tao,Genshu Wang,Jian Sun,Oscar Junhong Luo,Chen Qu,Wencai Ye,Jian Hong

Journal Article

Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate cells

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Journal Article

Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Journal Article

mA reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation

Journal Article

Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on

Zhen Zhang, Na Jiang, Zhaohui Ni

Journal Article