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Gene Expression Omnibus 1

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lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1–mitochondrial complex

Frontiers of Medicine doi: 10.1007/s11684-024-1065-7

Abstract: Herein, a previously unknown lncRNA, Gm20257, was identified.The suppression of Gm20257 by using small interfering RNAs significantly induced cardiomyocyte hypertrophyConversely, the overexpression of Gm20257 through plasmid transfection or adeno-associated viral vectorImportantly, Gm20257 restored mitochondrial complex IV level and enhanced mitochondrial function.These findings suggest that Gm20257 improves mitochondrial function through the PGC-1α–mitochondrial

Keywords： lncRNA Gm20257     cardiac hypertrophy     PGC-1α     mitochondrial complex IV     ATP    

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Analysis of GM（1，1）Model and Its Application in Fire Risk Prediction

Chen Zijin,Wang Fuliang,Lu Shouxiang

Strategic Study of CAE 2007, Volume 9, Issue 5,   Pages 91-94

Abstract:

Theoretical analysis of grey prediction model GM(1, 1) is present inMonotonicity of predicted value and its variation tendency predicted by GM(1, 1)model is proved.on the monotonicity of predicted value and its variation tendency,  applicability criterion of GM

Keywords： fire forecast     GM(1     1)     rate of the fire injured    

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Non-equidistant GM(1,1) power model and its application in engineering

Wang Zhengxin,Dang Yaoguo,Liu Sifeng

Strategic Study of CAE 2012, Volume 14, Issue 7,   Pages 98-102

Abstract: text-align: justify;">Aiming at the problem of modeling for non-equidistant sequence, the non-equidistant GMThe results showed that the form of non equidistant GM(1,1) power model was more flexible than the traditionalBoth non equidistant GM(1,1) model and Grey Verhulst model were the special cases of non equidistantGM(1,1) power model.shows modeling accuracy in traditional modeling, which was significantly improved by non equidistant GM

Keywords： grey system     non-equidistant sequence     GM(1     1) power model     parameter optimization    

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The Optimization of Grey Model GM (1,1)

Luo Dang,Liu Sifeng,Dang Yaoguo

Strategic Study of CAE 2003, Volume 5, Issue 8,   Pages 50-53

Abstract:

This paper analyzes the reason that grey model GM (1,1) often makes errors in simulated data.By contrasting the optimum one to the GM (1,1) about the simulation, it can be concluded that the structuremethod of background value in grey model GM (1,1) has an important influence on the prediction and adaptabilityThe optimum background value makes grey model GM (1,1) have better fitting and forecasting precision.

Keywords： grey model GM (1     1)     winterization equation     background value    

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Study on Improvement of Token and Arithmetic of Interval Grey Numbers and Its GM(1,1) Model

Fang Zhigeng,Liu Sifeng,Lu Fang,Wan Jun,Liu Bin

Strategic Study of CAE 2005, Volume 7, Issue 2,   Pages 57-61

Abstract: Last, the paper established the GM (1,1) model based on the interval grey number and got a good effect

Keywords： interval grey number     standard interval grey number     token     GM(1     1) model     computation rules    

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lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression

Frontiers of Medicine 2024, Volume 18, Issue 3,   Pages 484-498 doi: 10.1007/s11684-023-1036-4

Abstract: lncRNA ZNF593 antisense (ZNF593-AS) transcripts have been implicated in heart failure through the regulation

Keywords： lncRNA     ZNF593-AS     cardiac hypertrophy     Mfn2     oxidative phosphorylation.    

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Study on a kind of new strengthening buffer operators and numerical simulations

Cui Jie,Dang Yaoguo,Liu Sifeng,Xie Naiming

Strategic Study of CAE 2010, Volume 12, Issue 2,   Pages 108-112

Abstract: buffer operators, the kind of new strengthening buffer operators increases the forecast precision of GM

Keywords： operator     strengthening buffer operator     geometry average strengthening operator     GM(1     1)    

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Hemophagocytic lymphohistiocytosis: critical reappraisal of a potentially under-recognized condition

Somanath Padhi, Renu G’ Boy Varghese, Anita Ramdas, Manjiri Dilip Phansalkar, RajLaxmi Sarangi

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 492-498 doi: 10.1007/s11684-013-0292-0

Abstract: presumed to have been exacerbated by administration of granulocyte monocyte colony stimulating factor (GM-CSF

Keywords： hemophagocytic lymphohistiocytosis     diagnosis     therapy     GM-CSF     bone marrow    

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Global transcriptome analysis for identification of interactions between coding and noncoding RNAs during human erythroid differentiation

Nan Ding,Jiafei Xi,Yanming Li,Xiaoyan Xie,Jian Shi,Zhaojun Zhang,Yanhua Li,Fang Fang,Sihan Wang,Wen Yue,Xuetao Pei,Xiangdong Fang

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 297-310 doi: 10.1007/s11684-016-0452-0

Abstract: In the present study, we compared the dynamics of coding genes, miRNA, and lncRNA expression profiles

Keywords： erythroid differentiation     hematopoietic stem cell     RNA-seq     miRNA     lncRNA    

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Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis

Frontiers of Medicine 2023, Volume 17, Issue 5,   Pages 924-938 doi: 10.1007/s11684-023-1004-z

Abstract: In the current study, the lncRNA LOC646029 was markedly downregulated in metastatic ovarian tumors compared

Keywords： ovarian cancer     lncRNA LOC646029     metastasis     microRNA 627-3p     SPRED1    

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Effects of vitrification and cryostorage duration on single-cell RNA-Seq profiling of vitrified-thawed human metaphase II oocytes

Ying Huo, Peng Yuan, Qingyuan Qin, Zhiqiang Yan, Liying Yan, Ping Liu, Rong Li, Jie Yan, Jie Qiao

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 144-154 doi: 10.1007/s11684-020-0792-7

Abstract: Oocyte cryopreservation is widely used for clinical and social reasons. Previous studies have demonstrated that conventional slow-freezing cryopreservation procedures, but not storage time, can alter the gene expression profiles of frozen oocytes. Whether vitrification procedures and the related frozen storage durations have any effects on the transcriptomes of human metaphase II oocytes remain unknown. Four women (30–32 years old) who had undergone IVF treatment were recruited for this study. RNA-Seq profiles of 3 fresh oocytes and 13 surviving vitrified-thawed oocytes (3, 3, 4, and 3 oocytes were cryostored for 1, 2, 3, and 12 months) were analyzed at a single-cell resolution. A total of 1987 genes were differentially expressed in the 13 vitrified-thawed oocytes. However, no differentially expressed genes were found between any two groups among the 1-, 2-, 3-, and 12-month storage groups. Further analysis revealed that the aberrant genes in the vitrified oocytes were closely related to oogenesis and development. Our findings indicated that the effects of vitrification on the transcriptomes of mature human oocytes are induced by the procedure itself, suggesting that long-term cryostorage of human oocytes is safe.

Keywords： human metaphase II oocyte     vitrification     cryostorage duration     single-cell RNA-Seq     lncRNA    

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Long non-coding RNA SAP30-2:1 is downregulated in congenital heart disease and regulates cell proliferation by targeting HAND2

Jing Ma, Shiyu Chen, Lili Hao, Wei Sheng, Weicheng Chen, Xiaojing Ma, Bowen Zhang, Duan Ma, Guoying Huang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 91-100 doi: 10.1007/s11684-020-0778-5

Abstract: mining, bioinformatics analysis, and analysis of clinical tissue samples and observed that the novel lncRNAKnockdown of lncRNA SAP30-2:1 inhibited the proliferation of human embryonic kidney and AC16 cells andMoreover, lncRNA SAP30-2:1 was associated with HAND2 by RNA immunoprecipitation.Overall, these results suggest that lncRNA SAP30-2:1 may be involved in heart development through affecting

Keywords： congenital heart disease     Gene Expression Omnibus     lncRNA SAP30-2:1     cell proliferation     RNA immunoprecipitation    

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Title Author Date Type Operation

lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1–mitochondrial complex

Journal Article

Analysis of GM（1，1）Model and Its Application in Fire Risk Prediction

Chen Zijin,Wang Fuliang,Lu Shouxiang

Journal Article

Non-equidistant GM(1,1) power model and its application in engineering

Wang Zhengxin,Dang Yaoguo,Liu Sifeng

Journal Article

The Optimization of Grey Model GM (1,1)

Luo Dang,Liu Sifeng,Dang Yaoguo

Journal Article

Study on Improvement of Token and Arithmetic of Interval Grey Numbers and Its GM(1,1) Model

Fang Zhigeng,Liu Sifeng,Lu Fang,Wan Jun,Liu Bin

Journal Article

lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression

Journal Article

Study on a kind of new strengthening buffer operators and numerical simulations

Cui Jie,Dang Yaoguo,Liu Sifeng,Xie Naiming

Journal Article

Hemophagocytic lymphohistiocytosis: critical reappraisal of a potentially under-recognized condition

Somanath Padhi, Renu G’ Boy Varghese, Anita Ramdas, Manjiri Dilip Phansalkar, RajLaxmi Sarangi

Journal Article

Global transcriptome analysis for identification of interactions between coding and noncoding RNAs during human erythroid differentiation

Nan Ding,Jiafei Xi,Yanming Li,Xiaoyan Xie,Jian Shi,Zhaojun Zhang,Yanhua Li,Fang Fang,Sihan Wang,Wen Yue,Xuetao Pei,Xiangdong Fang

Journal Article

Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis

Journal Article

Effects of vitrification and cryostorage duration on single-cell RNA-Seq profiling of vitrified-thawed human metaphase II oocytes

Ying Huo, Peng Yuan, Qingyuan Qin, Zhiqiang Yan, Liying Yan, Ping Liu, Rong Li, Jie Yan, Jie Qiao

Journal Article

Long non-coding RNA SAP30-2:1 is downregulated in congenital heart disease and regulates cell proliferation by targeting HAND2

Jing Ma, Shiyu Chen, Lili Hao, Wei Sheng, Weicheng Chen, Xiaojing Ma, Bowen Zhang, Duan Ma, Guoying Huang

Journal Article