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Journal Article 15

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2023 1

2022 2

2021 1

2020 2

2019 2

2017 1

2015 2

2014 1

2013 1

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Keywords

metabolomics 7

Metabolomics 5

Efficacy 2

metabolites 2

stilbene 2

transcriptomics 2

2-Hydroxybutyric acid 1

Bacillus licheniformis 1

Catharanthus roseus 1

Polygonum multiflorum 1

ARTP mutagenesis 1

Astragalus 1

BPA 1

Bioactive compound 1

Biomarkers 1

Chinese herbal medicine 1

Chinmedomics 1

Correlation networks 1

Disease subtypes 1

Dysregulation correlation 1

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Progress in NMR-based metabolomics of

Qifang PAN,Jingya ZHAO,Yuliang WANG,Kexuan TANG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 3, Pages 195-204 doi: 10.15302/J-FASE-2015063

Abstract: Metabolomics has been rapidly developed as an important field in plant sciences and natural productsNMR-based metabolomics has been used in studies of for pathway elucidation, understanding stress responses

Keywords： Catharanthus roseus monoterpenoid indole alkaloids NMR metabolomics

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Time-dependent metabolomics uncover dynamic metabolic adaptions in MCF-7 cells exposed to bisphenol A

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 1, doi: 10.1007/s11783-023-1604-5

Abstract:

● Metabolomic temporal profiling of cells exposed to xenobiotics.

Keywords： Metabolomics BPA MCF-7 Temporal profiling Metabolic adaption Dysregulation correlation

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Metabolomics in human type 2 diabetes research

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 4-13 doi: 10.1007/s11684-013-0248-4

Abstract: The emergence of metabolomics has allowed researchers to systemically measure the small molecule metabolitesDuring the last decade, the progression made in metabolomics has provided insightful information on diseaseRecent studies using metabolomics approach coupled with statistical tools to predict incident diabetes

Keywords： metabolomics type 2 diabetes metabolic pathway mass spectrometry nuclear magnetic resonance (NMR)

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Sepsis biomarkers: an omics perspective

Xiao Liu, Hui Ren, Daizhi Peng

Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 58-67 doi: 10.1007/s11684-014-0318-2

Abstract: available and novel sepsis biomarkers in the context of genomics, transcriptomics, proteomics, and metabolomics

Keywords： sepsis biomarker genomics transcriptomics proteomics metabolomics

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High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome

Heng Fang, Aihua Zhang, Xiaohang Zhou, Jingbo Yu, Qi Song, Xijun Wang

Frontiers of Medicine 2020, Volume 14, Issue 5, Pages 651-663 doi: 10.1007/s11684-019-0709-5

Abstract: High-throughput metabolomics can clarify the underlying molecular mechanism of diseases via the qualitativeWe used integrated analysis to communicate the multiple results of metabolomics and network pharmacologyOur study indicated that the combination of high-throughput metabolomics and network pharmacology is

Keywords： metabolomics liquid chromatography-mass spectrometry metabolites metabolic pathways

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Genomic and metabolomic analysis of with enhanced poly--glutamic acid production through atmospheric and room temperature plasma mutagenesis

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 12, Pages 1751-1760 doi: 10.1007/s11705-022-2211-x

Abstract: Poly-γ-glutamic acid is an extracellular polymeric substance with various applications owing to its valuable properties of biodegradability, flocculating activity, water solubility, and nontoxicity. However, the ability of natural strains to produce poly-γ-glutamic acid is low. Atmospheric and room temperature plasma was applied in this study to conduct mutation breeding of Bacillus licheniformis CGMCC 2876, and a mutant strain M32 with an 11% increase in poly-γ-glutamic acid was obtained. Genome resequencing analysis identified 7 nonsynonymous mutations of ppsC encoding lipopeptide synthetase associated with poly-γ-glutamic acid metabolic pathways. From molecular docking, more binding sites and higher binding energy were speculated between the mutated plipastatin synthase subunit C and glutamate, which might contribute to the higher poly-γ-glutamic acid production. Moreover, the metabolic mechanism analysis revealed that the upregulated amino acids of M32 provided substrates for glutamate and promoted the conversion between L- and D-glutamate acids. In addition, the glycolytic pathway is enhanced, leading to a better capacity for using glucose. The maximum poly-γ-glutamic acid yield of 14.08 g·L^–1 was finally reached with 30 g·L^–1 glutamate.

Keywords： ARTP mutagenesis Bacillus licheniformis poly-γ-glutamic acid metabolomics

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Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Review

Ai-Hua Zhang, Hui Sun, Guang-Li Yan, Ying Han, Qi-Qi Zhao, Xi-Jun Wang

Engineering 2019, Volume 5, Issue 1, Pages 60-68 doi: 10.1016/j.eng.2018.11.008

Abstract: The serum pharmacochemistry of the TCM approach with metabolomics were integrated to establish an innovative

Keywords： Chinmedomics Serum pharmacochemistry of TCM Efficacy Metabolomics Syndrome Biomarkers Quality markers

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Functional Metabolomics Reveals that Astragalus Polysaccharides Improve Lipids Metabolism through Article

Bingbing Li, Ying Hong, Yu Gu, Shengjie Ye, Kaili Hu, Jian Yao, Kan Ding, Aihua Zhao, Wei Jia, Houkai Li

Engineering 2022, Volume 9, Issue 2, Pages 111-122 doi: 10.1016/j.eng.2020.05.023

Abstract: Functional metabolomics is increasingly used to investigate systemic effects on the host by identifyingunderlying the metabolic benefits of Astragalus polysaccharides (APS) by adopting a functional metabolomicsThen, gas chromatography–time-of-flight mass spectrometry (GC–TOFMS)-based untargeted metabolomicsThen, metabolomics analysis revealed that APS supplementation reversed the HFD-induced metabolic changesOur results also highlight that functional metabolomics is practical for investigating the mechanism

Keywords： Astragalus polysaccharides (APS) Functional metabolomics 2-Hydroxybutyric acid Obesity

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Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb

Jiabo Wang,Zhijie Ma,Ming Niu,Yun Zhu,Qingsheng Liang,Yanling Zhao,Jingyuan Song,Zhaofang Bai,Yaming Zhang,Ping Zhang,Na Li,Yakun Meng,Qi Li,Lushan Qin,Guangju Teng,Junling Cao,Baosen Li,Shilin Chen,Yonggang Li,Zhengsheng Zou,Honghao Zhou,Xiaohe Xiao

Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 457-467 doi: 10.1007/s11684-015-0417-8

Abstract:

Herbal medicines have recently been recognized as the second most common cause of drug-induced liver injury (DILI) in the United States. However, reliable methods to identify the DILI causality of some herbs, such as Heshouwu (dried root of Polygonum multiflorum), remain lacking. In this study, a total of 12 307 inpatients with liver dysfunction and 147 literature-reported cases of Heshouwu DILI were screened. A general algorithm indicated that only 22.5% (9/40) and 30.6% (45/147) of all hospitalization and literature case reports, respectively, demonstrate the high probability of DILI causality of Heshouwu. By contrast, 95% (19/20) of all cases prospectively investigated by pharmacognosy, phytochemistry, and metabolomic tests exhibited highly probable causality, including a patient who was previously incorrectly attributed and a case that was excluded from Heshouwu causality by pharmacognostic evidence. Toxin (heavy metals, pesticides, and mycotoxins) contamination was also excluded from Heshouwu DILI causality. The objectivity of these screening methods for Heshouwu DILI diagnosis addresses safety concerns regarding stilbene-containing herbal medicines and dietary supplements.

Keywords： drug-induced liver injury pharmacognosy metabolomics stilbene Polygonum multiflorum Chinese herbal

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Photosynthesis and related metabolic mechanism of promoted rice (Oryza sativa L.) growth by TiO₂ nanoparticles

Yingdan Zhang, Na Liu, Wei Wang, Jianteng Sun, Lizhong Zhu

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 6, doi: 10.1007/s11783-020-1282-5

Abstract: Abstract • The rice growth was promoted by nano-TiO2 of 0.1–100 mg/L. • Nano-TiO2 enhanced the energy storage in photosynthesis. • Nano-TiO2 reduced energy consumption in carbohydrate metabolism and TCA cycle. Titanium dioxide nanoparticle (nano-TiO2), as an excellent UV absorbent and photo-catalyst, has been widely applied in modern industry, thus inevitably discharged into environment. We proposed that nano-TiO2 in soil can promote crop yield through photosynthetic and metabolic disturbance, therefore, we investigated the effects of nano-TiO2 exposure on related physiologic-biochemical properties of rice (Oryza sativa L.). Results showed that rice biomass was increased >30% at every applied dosage (0.1–100 mg/L) of nano-TiO2. The actual photosynthetic rate (Y(II)) significantly increased by 10.0% and 17.2% in the treatments of 10 and 100 mg/L respectively, indicating an increased energy production from photosynthesis. Besides, non-photochemical quenching (Y(NPQ)) significantly decreased by 19.8%–26.0% of the control in all treatments respectively, representing a decline in heat dissipation. Detailed metabolism fingerprinting further revealed that a fortified transformation of monosaccharides (D-fructose, D-galactose, and D-talose) to disaccharides (D-cellobiose, and D-lactose) was accompanied with a weakened citric acid cycle, confirming the decrease of energy consumption in metabolism. All these results elucidated that nano-TiO2 promoted rice growth through the upregulation of energy storage in photosynthesis and the downregulation of energy consumption in metabolism. This study provides a mechanistic understanding of the stress-response hormesis of rice after exposure to nano-TiO2, and provides worthy information on the potential application and risk of nanomaterials in agricultural production.

Keywords： Nano-TiO₂ Rice Photosynthesis Metabolomics Energy storage

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Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum

Chunyu Li, Ming Niu, Zhaofang Bai, Congen Zhang, Yanling Zhao, Ruiyu Li, Can Tu, Huifang Li, Jing Jing, Yakun Meng, Zhijie Ma, Wuwen Feng, Jinfa Tang, Yun Zhu, Jinjie Li, Xiaoya Shang, Zhengsheng Zou, Xiaohe Xiao, Jiabo Wang

Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 253-265 doi: 10.1007/s11684-017-0508-9

Abstract: In addition, plasma metabolomics analysis showed that cis-SG-disturbing enriched pathways

Keywords： Polygonum multiflorum idiosyncratic hepatotoxicity metabolomics stilbene cis-transisomerization

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METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN FRESH SHOOTS OF TEA (

Chen-Kai JIANG, De-Jiang NI, Ming-Zhe YAO, Jian-Qiang MA, Liang CHEN

Frontiers of Agricultural Science and Engineering Pages 215-230 doi: 10.15302/J-FASE-2021382

Abstract: Metabolites, especially secondary metabolites, are very important in the adaption of tea plants and the quality of tea products. Here, we focus on the seasonal variation in metabolites of fresh tea shoots and their regulatory mechanism at the transcriptional level. The metabolic profiles of fresh tea shoots of 10 tea accessions collected in spring, summer, and autumn were analyzed using ultra-performance liquid chromatography coupled with quadrupole-obitrap mass spectrometry. We focused on the metabolites and key genes in the phenylpropanoid/flavonoid pathway integrated with transcriptome analysis. Multivariate statistical analysis indicates that metabolites were distinctly different with seasonal alternation. Flavonoids, amino acids, organic acids and alkaloids were the predominant metabolites. Levels of most key genes and downstream compounds in the flavonoid pathway were lowest in spring but the catechin quality index was highest in spring. The regulatory pathway was explored by constructing a metabolite correlation network and a weighted gene co-expression network.

Keywords： harvest season metabolites tea shoots transcriptomics untargeted metabolomics

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Alterations in the Gut Microbiome in Liver Recipients with Post-transplant Diabetes Mellitus

Qi Ling,Yuqiu Han,Yue Ma,Xiaosen Wang,Zheng Zhu,Jingyu Wang,Jiaying Cao,Lin Xiaohan,Jun Wang,Baohong Wang,

Engineering doi: 10.1016/j.eng.2023.09.006

Abstract: Here, by combining high-throughput shotgun metagenomics sequencing and metabolomics profiling, we characterizedAdditionally, the altered microbes, as well as the microbial metabolomics, correlated with the dosage

Keywords： Post-transplant diabetes mellitus Tacrolimus Metagenomics Metabolomics

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Traditional Chinese Medicine-Based Subtyping of Early-Stage Type 2 Diabetes Using Plasma Metabolomics Article

Min He, Mengmeng Sun, Slavik Koval, Roeland Van Wijk, Thomas Hankemeier, Jan Van der Greef, Eduard P.A. Van Wijk, Mei Wang

Engineering 2019, Volume 5, Issue 5, Pages 916-923 doi: 10.1016/j.eng.2019.03.011

Abstract: personalized diagnostics can be improved to yield a biochemical basis for such strategies; for example, metabolomicsIn this study, we investigated the feasibility of using plasma metabolomics obtained from 44 pre-diabeticWe studied the relationship between plasma metabolomics and UPE with respect to TCM-based subtyping inPlasma metabolomics data indicate that the lipid profile is an essential component captured by UPE withPlasma metabolomics thus provides biochemical insights into system-based UPE measurements.

Keywords： Type 2 diabetes mellitus Plasma metabolites Disease subtypes Ultra-weak photon emission Correlation networks

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A Clinical and Animal Experiment Integrated Platform for Small-Molecule Screening Reveals Potential Targets of Bioactive Compounds from a Herbal Prescription Based on the Therapeutic Efficacy of Yinchenhao Tang for Jaundice Syndrome Article

Hui Xiong, Ai-Hua Zhang, Ya-Jing Guo, Xiao-Hang Zhou, Hui Sun, Le Yang, Heng Fang, Guang-Li Yan, Xi-Jun Wang

Engineering 2021, Volume 7, Issue 9, Pages 1293-1305 doi: 10.1016/j.eng.2020.12.016

Abstract: ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UPLC-Q-ToF-MS)-based metabolomics

Keywords： Efficacy Bioactive compound Small molecule Targets Herbal medicine Metabolomics

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Title Author Date Type Operation

Progress in NMR-based metabolomics of

Qifang PAN,Jingya ZHAO,Yuliang WANG,Kexuan TANG

Journal Article

Time-dependent metabolomics uncover dynamic metabolic adaptions in MCF-7 cells exposed to bisphenol A

Journal Article

Metabolomics in human type 2 diabetes research

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Journal Article

Sepsis biomarkers: an omics perspective

Xiao Liu, Hui Ren, Daizhi Peng

Journal Article

High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome

Heng Fang, Aihua Zhang, Xiaohang Zhou, Jingbo Yu, Qi Song, Xijun Wang

Journal Article

Genomic and metabolomic analysis of with enhanced poly--glutamic acid production through atmospheric and room temperature plasma mutagenesis

Journal Article

Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the

Ai-Hua Zhang, Hui Sun, Guang-Li Yan, Ying Han, Qi-Qi Zhao, Xi-Jun Wang

Journal Article

Functional Metabolomics Reveals that Astragalus Polysaccharides Improve Lipids Metabolism through

Bingbing Li, Ying Hong, Yu Gu, Shengjie Ye, Kaili Hu, Jian Yao, Kan Ding, Aihua Zhao, Wei Jia, Houkai Li

Journal Article

Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb

Journal Article

Photosynthesis and related metabolic mechanism of promoted rice (Oryza sativa L.) growth by TiO₂ nanoparticles

Yingdan Zhang, Na Liu, Wei Wang, Jianteng Sun, Lizhong Zhu

Journal Article

Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum

Journal Article

METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN FRESH SHOOTS OF TEA (

Chen-Kai JIANG, De-Jiang NI, Ming-Zhe YAO, Jian-Qiang MA, Liang CHEN

Journal Article

Alterations in the Gut Microbiome in Liver Recipients with Post-transplant Diabetes Mellitus

Qi Ling,Yuqiu Han,Yue Ma,Xiaosen Wang,Zheng Zhu,Jingyu Wang,Jiaying Cao,Lin Xiaohan,Jun Wang,Baohong Wang,

Journal Article

Traditional Chinese Medicine-Based Subtyping of Early-Stage Type 2 Diabetes Using Plasma Metabolomics

Min He, Mengmeng Sun, Slavik Koval, Roeland Van Wijk, Thomas Hankemeier, Jan Van der Greef, Eduard P.A. Van Wijk, Mei Wang

Journal Article

Hui Xiong, Ai-Hua Zhang, Ya-Jing Guo, Xiao-Hang Zhou, Hui Sun, Le Yang, Heng Fang, Guang-Li Yan, Xi-Jun Wang

Journal Article

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