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MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 72-80 doi: 10.15302/J-FASE-2016089

Abstract: In our study, we found by qRT-PCR that miR-148b was significantly upregulated in sheep wool follicleOverexpression of miR-148b promoted proliferation of both HHDPC and HHGMC.By using the TOPFlash system we demonstrated that miR-148b could activate Wnt/β-catenin pathway andSubsequently was further identified as the target of miR-148b using western blotting.These results were considered to indicate that miR-148b could activate the Wnt/β-catenin signal pathway

Keywords： miR-148b     hair follicle     proliferation     NFAT5     Wnt10b    

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The microRNA, miR-29c, participates in muscle development through targeting the

Weiya ZHANG,Wei WEI,Yuanyuan ZHAO,Shuhong ZHAO,Xinyun LI

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 4,   Pages 311-317 doi: 10.15302/J-FASE-2015075

Abstract: Previous studies indicated that miR-29c is important for muscle development in mice and human, but itsIn this study, we detected the expression of miR-29c in Meishan longissimus lumborum (LL) muscle.The results showed that miR-29c was gradually upregulated during development of skeletal muscle in pigMoreover, the expression of and genes, which were confirmed to be targeted by miR-29c in mice, wasAlso, the luciferase assay indicated that miR-29s can target the gene in pigs.

Keywords： pig     miR-29c     skeletal muscle     expression     SNP    

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Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and

Runlin Shi,Haibing Xiao,Tao Yang,Lei Chang,Yuanfeng Tian,Bolin Wu,Hua Xu

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 456-463 doi: 10.1007/s11684-014-0353-z

Abstract: In this study, Du145 cells were transfected with miR-200c mimics or negative control miR-NC by usingThe relative expression of miR-200c was measured by RT-PCR.Du145 cells were then transfected with miR-200c mimics and displayed lower abilities of proliferationHence, miR-200c could significantly inhibit the proliferation of the prostate cancer cell line Du145;likewise, miR-200c could inhibit migration and invasion by epithelial-mesenchymal transition.

Keywords： miR-200c     proliferation     migration     invasion     prostate cancer     Du145 cell     ZEB1    

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The expression mode of hsa-miR-197 in uterine leiomyomas tissue and related bioinformatics analysis

Xu Qing,Fu Ziyi,Wu Xiaoli,Huangfu Yushuang and Ling Jing

Strategic Study of CAE 2014, Volume 16, Issue 5,   Pages 99-104

Abstract:

We performed Real-time PCR to detect the hsa-miR-197 expression levelsmiRbase，UCSC，NCBI are employed to analysis the sequence conservation and genetic characteristics of hsa- miR- 197；miRNA databases such as miRanda，MirTarget2 and TargetScan are chosen to predict hsa- miR- 197 targetchosen，and GO and Pathway analysis of these genes are carried out to explore the potential role of hsa-miR-197 playing in regulating the uterine leiomyomas occurrence and development. hsa-miR-197 functions in

Keywords： uterine leiomyomas     hsa-miR-197     bioinformatics analysis     target genes    

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Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer

Bo Zhou, Hongbin Xu, Meng Xia, Chaoyang Sun, Na Li, Ensong Guo, Lili Guo, Wanying Shan, Hao Lu, Yifan Wu, Yuan Li, Degui Yang, Danhui Weng, Li Meng, Junbo Hu, Ding Ma, Gang Chen, Kezhen Li

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 214-222 doi: 10.1007/s11684-017-0518-7

Abstract: Dysfunctional miR-9 expression remains ambiguous, and no consensus on the metastatic progression of ovarianbioinformatics analysis show that the 3′-UTR of the E-cadherin mRNA was directly regulated by miRLuciferase reporter assay results confirmed that miR-9 could directly target this 3′-UTR. miR-9Upregulation of miR-9 could downregulate the expression of E-cadherin but upregulate the expression ofcould be effectively inhibited via miR-9 inhibitor.

Keywords： ovarian cancer     metastasis     miR-9     E-cadherin    

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-Derived miR162a Functions on Osteoporosis Through Directly Promoting Osteoblast Formation

Chunyan Gu,Xichao Yu,Xiaozhu Tang,Leilei Gong,Jingquan Tan,Yuanjiao Zhang,Huili Zheng,Ze Wang,Chenqian Zhang,Yejin Zhu,Zuojian Zhou,Heming Yu,Kai Xu,Jinao Duan,Xiaosong Gu,Ye Yang,

Engineering doi: 10.1016/j.eng.2023.09.007

Abstract: Illumina deep sequencing analysis and stem-loop polymerase chain reaction (PCR) assay revealed that miR162aImmunofluorescence staining showed that miR162a was absorbed through systemic RNA interference defectiveBioinformatics prediction and luciferase reporter assay identified that miR162a targeted nuclear receptorAlizarin red staining and micro-computed tomography (microCT) confirmed that miR162a promoted osteogenicIn addition, transgenic Nicotiana benthamiana (N. benthamiana) leaves overexpressing miR162a were developed

Keywords： Traditional Chinese medicine     Lycium barbarum     L     miR162a     Osteoporosis     Nuclear receptor corepressor     Transgenic    

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Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 642-650 doi: 10.1007/s11684-019-0719-3

Abstract: This study aimed to investigate the correlation between serum miR-154-5p and urinary albumin to creatinineCirculating miR-154-5p, inflammatory (C-reactive protein (CRP); erythrocyte sedimentation rate (ESR);UACR, miR-154-5p, glycated hemoglobin (HbA1c), serum creatinine (sCr), blood urea nitrogen (BUN), ESRElevated levels of UACR and miR-154-5p were directly correlated with HbA1c, sCr, BUN, ESR, CRP, VEGF,These findings indicated that elevated serum miR-154-5p is significantly correlated with high UACR in

Keywords： type 2 diabetes mellitus     diabetic kidney disease     miR-154-5p     urinary albumin to creatinine ratio    

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Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR

Frontiers of Medicine   Pages 924-938 doi: 10.1007/s11684-023-1004-z

Abstract: Mechanistically, LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related

Keywords： ovarian cancer     lncRNA LOC646029     metastasis     microRNA 627-3p     SPRED1    

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ovarian tumors to safely and successfully become pregnant---a Chinese retrospective cohort study among 148

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 509-517 doi: 10.1007/s11684-017-0554-3

Abstract:

This study was performed to evaluate the oncological and reproductive outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumors in China. One hundred and forty eight non-epithelial ovarian tumor women treated with FSS between January 1, 2000 and August 31, 2015 from two medical centers in China were identified. Progression-free survival (PFS) was 88.5%, whereas overall survival (OS) was 93.9%. Univariate analysis suggested that delivery after treatment is related to PFS (P=0.023), whereas histology significantly influenced OS. Cox regression analysis suggested that only histology was associated with PFS and OS (P<0.05). Among the 129 women who completed adjuvant chemotherapy (ACT), none developed amenorrhea. Among the 44 women who desired pregnancy, 35 (79.5%) successfully had 51 gestations including 35 live births without birth defects. Non-epithelial ovarian tumors can achieve fulfilling prognosis after FSS and chemotherapy. Histology might be the only independent prognostic factor for PFS and OS. FSS followed by ACT appeared to have little or no effect on fertility. Meanwhile, postoperative pregnancy did not increase the PFS or OS. Use of gonadotropin-releasing hormone agonist was not beneficial for fertility.

Keywords： malignant germ cell tumors     ovarian sex cord-stromal tumors     fertility-sparing surgery     prognosis     fertility    

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lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 317-329 doi: 10.1007/s11684-022-0931-4

Abstract: Further results revealed that overexpression of the lncR-GAS5-targeted gene miR-193-5p promoted autophagyNotably, miR-193-5p overexpression decreased plaque size and increased collagen content.In conclusion, lncR-GAS5 overexpression arrested endothelial autophagy through the miR-193-5p/SRSF10Thus, miR-193-5p/SRSF10 may serve as a novel treatment target for atherosclerosis.

Keywords： lncR-GAS5     miR-193-5p     splicing factor SRSF10     autophagy     atherogenesis    

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Current hepatitis B treatment guidelines and future research directions

Jonathan Skupsky,Ke-Qin Hu

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 145-157 doi: 10.1007/s11684-014-0335-1

Abstract:

Hepatitis B virus (HBV) infection causes a tremendous clinical burden across the world with more than

Keywords： chronic hepatitis B     HBV treatment guidelines     APASL guidelines     EASL guidelines     AASLD guidelines    

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Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 111-125 doi: 10.1007/s11684-021-0854-5

Abstract: 19 patients, the association of liver injury caused by specific subtype especially chronic hepatitis B

Keywords： COVID-19     chronic hepatitis B     liver injury     coagulation dysfunction    

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Vaccine therapies for chronic hepatitis B: can we go further?

Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 17-23 doi: 10.1007/s11684-014-0313-7

Abstract:

Chronic hepatitis B is a major health burden worldwide.treatment, therapeutic vaccination is a promising new strategy for the control of chronic hepatitis B.basis of the major specific and non-specific immune dysregulations and defects in chronic hepatitis B

Keywords： chronic hepatitis B     therapeutic     antigen-antibody complexes     DNA     vaccine    

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Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China

Rui Yu,Rong Fan,Jinlin Hou

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 135-144 doi: 10.1007/s11684-014-0331-5

Abstract:

Chronic hepatitis B is a major health problem in China.The universal vaccination program since 1992 has changed the epidemiology of hepatitis B virus infectionThe most prevalent hepatitis B virus strains in China are genotypes B and C, whereas those in westernChronic hepatitis B poses a heavy burden to the society in China.

Keywords： chronic hepatitis B     epidemiology     prevention     treatment    

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Durability analysis of B grade steel side-frame based on the PFM method

Li Wei and Wang Ping

Strategic Study of CAE 2011, Volume 13, Issue 1,   Pages 56-61

Abstract: simulated durability test is performed to study the details with angle of side-frame of wagon bogie made of B

Keywords： durability     fatigue     B grade steel     crack    

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Title Author Date Type Operation

MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Journal Article

The microRNA, miR-29c, participates in muscle development through targeting the

Weiya ZHANG,Wei WEI,Yuanyuan ZHAO,Shuhong ZHAO,Xinyun LI

Journal Article

Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and

Runlin Shi,Haibing Xiao,Tao Yang,Lei Chang,Yuanfeng Tian,Bolin Wu,Hua Xu

Journal Article

The expression mode of hsa-miR-197 in uterine leiomyomas tissue and related bioinformatics analysis

Xu Qing,Fu Ziyi,Wu Xiaoli,Huangfu Yushuang and Ling Jing

Journal Article

Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer

Bo Zhou, Hongbin Xu, Meng Xia, Chaoyang Sun, Na Li, Ensong Guo, Lili Guo, Wanying Shan, Hao Lu, Yifan Wu, Yuan Li, Degui Yang, Danhui Weng, Li Meng, Junbo Hu, Ding Ma, Gang Chen, Kezhen Li

Journal Article

-Derived miR162a Functions on Osteoporosis Through Directly Promoting Osteoblast Formation

Chunyan Gu,Xichao Yu,Xiaozhu Tang,Leilei Gong,Jingquan Tan,Yuanjiao Zhang,Huili Zheng,Ze Wang,Chenqian Zhang,Yejin Zhu,Zuojian Zhou,Heming Yu,Kai Xu,Jinao Duan,Xiaosong Gu,Ye Yang,

Journal Article

Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

Journal Article

Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR

Journal Article

ovarian tumors to safely and successfully become pregnant---a Chinese retrospective cohort study among 148

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Journal Article

lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Journal Article

Current hepatitis B treatment guidelines and future research directions

Jonathan Skupsky,Ke-Qin Hu

Journal Article

Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center

Journal Article

Vaccine therapies for chronic hepatitis B: can we go further?

Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan

Journal Article

Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China

Rui Yu,Rong Fan,Jinlin Hou

Journal Article

Durability analysis of B grade steel side-frame based on the PFM method

Li Wei and Wang Ping

Journal Article