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Clostridium tyrobutyricum 1

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Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 784-798 doi: 10.1007/s11684-021-0911-0

Abstract: downstream signaling by interfering with the MAPK pathway and BCL2 survival pathway in GNAQ/11-mutant

Keywords： uveal melanoma     mutant GNAQ/11     palmitoylation     BCL2     combination target therapy    

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gene expression during melanoblasts migration in normal pigmented White Leghorn and hyperpigmented mutant

Yulin LI,Deping HAN,Junying LI,Dawn KOLTES,Xuemei DENG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 299-306 doi: 10.15302/J-FASE-2014040

Abstract: Melanoblasts originating from neural crest cells can migrate through the mesenchyme of the developed embryo and give rise to melanocytes. Unlike the melanocytes that are confined to the integument in other vertebrates, melanocytes in Silky Fowl can reach the ventral regions of the embryos owing to differences in gene expression in the process of melanoblasts migration. In this study, we used microarray profiling to identify differences in gene expression between White Leghorn and Silky Fowl. Differential expression of 2517 microarray probes ( <0.01, Fold Change>2) was observed in Silky Fowl compared to White Leghorn. After filtration by cluster analysis, functional annotation and pathway analysis, eight differentially expressed genes were identified to be closely related to the development of melanocytes. Moreover, differences in expression of immune genes were also detected between Silky Fowl and White Leghorn. The differentially expressed genes associated with melanocyte development were verified by q-PCR, and results were highly consistent with the microarray data. The genes with significantly altered expression involved in melanoblast migration and development suggested that different microenvironments resulted in the abnormal melanoblast migration in Silky Fowl, although there were no big differences in melanoblast development between these two breeds. The candidate genes discovered in this study are beneficial to understand the molecular mechanism of hyperpigmentation in Silky Fowl.

Keywords： Silky Fowl     White Leghorn     melanoblast migration     gene expression    

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and clinical application of anti-HBs monoclonal antibody that binds both wild-type and immune escape mutant

Fanghe LI BM , Chunyan ZHANG MS , Jinghua LIU MS , Xiaoyan ZHANG MS , Bing YAN , Bo ZHANG MS , Yongguo HUANG MS , Jingsong GONG BM , Yan CHEN BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 277-283 doi: 10.1007/s11684-009-0047-0

Abstract: antibody, we developed a sandwich ELISA (defined G6m ELISA) for detecting both wild-type and immune escape mutant

Keywords： hepatitis B virus     gene variation     hepatitis B surface antigen     immune escape     enzyme-linked immunosorbent assay    

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Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 412-420 doi: 10.1007/s11684-015-0423-x

Abstract:

Genetic mutations are considered to drive the development of acute myeloid leukemia (AML). With the rapid progress in sequencing technologies, many newly reported genes that are recurrently mutated in AML have been found to govern the initiation and relapse of AML. These findings suggest the need to distinguish the driver mutations, especially the most primitive single mutation, from the subsequent passenger mutations. Recent research on DNA methyltransferase 3A (DNMT3A) mutations provides the first proof-of-principle investigation on the identification of preleukemic stem cells (pre-LSCs) in AML patients. Although DNMT3A mutations alone may only transform hematopoietic stem cells into pre-LSCs without causing the full-blown leukemia, the function of this driver mutation appear to persist from AML initiation up to relapse. Therefore, identifying and targeting preleukemic mutations, such as DNMT3A mutations, in AML is a promising strategy for treatment and reduction of relapse risk.

Keywords： preleukemic stem cell     acute myeloid leukemia     relapse     DNMT3A    

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High production of butyric acid by

Chao Ma,Jianfa Ou,Matthew Miller,Sarah McFann,Xiaoguang (Margaret) Liu

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 3,   Pages 369-375 doi: 10.1007/s11705-015-1525-3

Abstract: to improve the production of butyric acid by process optimization using the metabolically engineered mutant

Keywords： Clostridium tyrobutyricum     butyric acid production     fermentation     mutant     pH     flux balance analysis    

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Comparative transcriptome analysis of purple-fleshed sweet potato provides insights into the molecular mechanism of anthocyanin biosynthesis

Hongyuan ZHAO, Shanshan ZHANG, Feibing WANG, Ning ZHAO, Shaozhen HE, Qingchang LIU, Hong ZHAI

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 2,   Pages 214-225 doi: 10.15302/J-FASE-2018219

Abstract: Jingshu 6 and its mutant JS6-5 with high anthocyanin content by high-throughput RNA sequencing.

Keywords： anthocyanin     gene expression     mutant     purple-fleshed sweet potato     transcriptome    

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High-Affinity Decoy PD-1 Mutant Screened from an Epitope-Specific Cell Library Article

Hao Liu, Chunxia Qiao, Naijing Hu, Zhihong Wang, Jing Wang, Jiannan Feng, Beifen Shen, Yuanfang Ma, Longlong Luo

Engineering 2021, Volume 7, Issue 11,   Pages 1557-1565 doi: 10.1016/j.eng.2020.11.011

Abstract: After three rounds of cell sorting, the decoy PD-1 mutant 463, which presented a higher affinity thanThe median effective concentration (EC50) value of the decoy mutant was 0.031&The 463 decoy mutant reversed the inhibitory function of PD-1 in T cell activation; furthermore, 10 

Keywords： Decoy PD-1     PD-L1     Mammalian cell library     Epitope-oriented    

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Title Author Date Type Operation

Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal

Journal Article

gene expression during melanoblasts migration in normal pigmented White Leghorn and hyperpigmented mutant

Yulin LI,Deping HAN,Junying LI,Dawn KOLTES,Xuemei DENG

Journal Article

and clinical application of anti-HBs monoclonal antibody that binds both wild-type and immune escape mutant

Fanghe LI BM , Chunyan ZHANG MS , Jinghua LIU MS , Xiaoyan ZHANG MS , Bing YAN , Bo ZHANG MS , Yongguo HUANG MS , Jingsong GONG BM , Yan CHEN BM ,

Journal Article

Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Journal Article

High production of butyric acid by

Chao Ma,Jianfa Ou,Matthew Miller,Sarah McFann,Xiaoguang (Margaret) Liu

Journal Article

Comparative transcriptome analysis of purple-fleshed sweet potato provides insights into the molecular mechanism of anthocyanin biosynthesis

Hongyuan ZHAO, Shanshan ZHANG, Feibing WANG, Ning ZHAO, Shaozhen HE, Qingchang LIU, Hong ZHAI

Journal Article

High-Affinity Decoy PD-1 Mutant Screened from an Epitope-Specific Cell Library

Hao Liu, Chunxia Qiao, Naijing Hu, Zhihong Wang, Jing Wang, Jiannan Feng, Beifen Shen, Yuanfang Ma, Longlong Luo

Journal Article