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Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleicacid drugs: learning from virus

Vaibhav Mundra, Ram I. Mahato

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 387-404 doi: 10.1007/s11705-014-1457-3

Abstract: many challenges in developing efficient and target specific delivery systems of small molecule and nucleicacid drugs.

Keywords： nanocarrier     cellular uptake     endosomal release     nucleic acid drug    

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Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 196-202 doi: 10.1007/s11705-016-1565-3

Abstract: X-ray crystallography is a powerful strategy for 3-D structure determination of macromolecules, such as nucleicacids and protein-nucleic acid complexes.Recently we have successfully developed synthesis and strategy of selenium-derivatized nucleic acids(SeNA) for nucleic acid crystallography.

Keywords： selenium     DNA     RNA     nucleic acid     crystallization    

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Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3,   Pages 275-286 doi: 10.1007/s11705-011-1203-z

Abstract: In the case of nucleic acid therapy, non-viral carriers face several biological barriers during the deliveryengineering and conjugation of multifunctional polymeric structures for the utilization as “tailor-made” nucleicacid carriers.

Keywords： conjugate     DNA     gene transfer     polymer     RNA     targeting    

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Validation of polarizable force field parameters for nucleic acids by inter-molecular interactions

Liaoran Cao,Hong Ren,Jing Miao,Wei Guo,Yan Li,Guohui Li

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 203-212 doi: 10.1007/s11705-016-1572-4

Abstract: Modeling structural and thermodynamic properties of nucleic acids has long been a challenge in the developmenthave been proved to be reliable to model small molecules, polypeptides and proteins, but their use on nucleicIn this article, the interactions between nucleic acids and a small molecule or ion were modeled by AMOEBAbio09

Keywords： nucleic acid     polarizable force field     AMOEBA    

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Nucleic acid-based diagnostics for infectious diseases in public health affairs

Albert Cheung-Hoi Yu, Greg Vatcher, Xin Yue, Yan Dong, Mao Hua Li, Patrick H. K. Tam, Parker Y.L. Tsang, April K.Y. Wong, Michael H.K. Hui, Bin Yang, Hao Tang, Lok-Ting Lau

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 173-186 doi: 10.1007/s11684-012-0195-5

Abstract: Nucleic acid-based diagnostics, detecting pathogens through the identification of their genomic sequencesHere we review some of the most popular nucleic acid-based diagnostics and focus on their adaptabilityWe also compare and contrast the characteristics of different types of nucleic acid-based diagnostics

Keywords： nucleic acid-based diagnostics     infectious disease     PCR     NASBA     LAMP     microarray     LOAC     public health affairs    

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Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Strategic Study of CAE 2021, Volume 23, Issue 4,   Pages 153-161 doi: 10.15302/J-SSCAE-2021.04.018

Abstract: This article first summarizes the R&D status of nucleic acid vaccines from the aspects of relatedacid vaccines.acid vaccines, and studies the possible technical and safety problems.Furthermore, we suggest that the key technologies of nucleic acid vaccines should be developed by improvingMoreover, the safety and efficacy of nucleic acid vaccines should be strictly monitored; stakeholders

Keywords： nucleic acid vaccine     deoxyribonucleic acid (DNA) vaccine     ribonucleic acid (RNA) vaccine     messenger    

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Flow cytometric assessment of the effects of chlorine, chloramine, and UV on bacteria by using nucleicacid stains and 5-cyano-2,3-ditolyltetrazolium chloride

Xuebiao Nie, Wenjun Liu, Mo Chen, Minmin Liu, Lu Ao

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 6, doi: 10.1007/s11783-016-0884-4

Abstract: Flow cytometry based on nucleic acid stains and CTC was established and optimized.Chlorine demonstrated stronger and faster destructive effects on cytomembrane than chloramine, and nucleic

Keywords： Flow cytometry     Escherichia coli     Staphylococcusaureus     UV     CTC     SYTO 9    

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Research Progress in Molecular Identification Technology for Microbial Resources

Zhang Yu, Ma Aijin, Gao Lifen, Peng Hai, Jia Yingmin, Sun Baoguo

Strategic Study of CAE 2021, Volume 23, Issue 5,   Pages 86-93 doi: 10.15302/J-SSCAE-2021.05.011

Abstract: application for microbial resources in China and abroad; these technologies include deoxyribonucleic acid(DNA) (G+C) mol% identification, nucleic acid hybridization, DNA fingerprinting, nucleic acid amplification

Keywords： microbial resources     molecular identification     nucleic acid amplification technique     gene chip technology    

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Development Strategy of Microbial Safety Industry

Song Zhongjian, Li Man, Hu Liangbin, Wang Chunming, Lu Xi, Liu Kaihui, Zhang Lijia, Yu Yan, Wu Qingping

Strategic Study of CAE 2021, Volume 23, Issue 5,   Pages 79-85 doi: 10.15302/J-SSCAE-2021.05.010

Abstract:

Microbial safety is crucial for China’s social and economic development in the new era, and it is an important support for national food security, public health, and social stability. In this article, we analyze the development needs and current status of the microbial safety industry considering the policy environment in China. Subsequently, we clarify the domestic and global development patterns of the industry and summarize the challenges faced by the innovation and application of pathogenic microorganism detection and control technologies in China. Furthermore, we propose a development plan for building China’s microbial safety industry. To explore a high-quality development path, China should build innovation platforms and a large scientific database regarding microbial safety, enhance personnel development for this industry, encourage leading enterprises to develop according to standards and regulations, and strengthen major system innovation and engineering technology research in the microbial safety field.

Keywords： microbial safety     microbial detection     microbial diagnosis     microbial prevention and control     nucleicacid detection    

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Sulfonic acid-functionalized mesoporous silica catalyst with different morphology for biodiesel production

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 8,   Pages 1198-1210 doi: 10.1007/s11705-021-2133-z

Abstract: Sulfonic acid functionalized mesoporous silica based solid acid catalysts with different morphology wereThe sulfonic acid functionalized mesoporous silica catalysts of spherical shape and the cube shape werecatalytic biodiesel production reaction over the catalysts were studied by esterification of free fatty acid, oleic acid with methanol.The effect of various reaction parameters such as catalyst concentration, acid/alcohol molar ratio, catalyst

Keywords： solid acid catalyst     mesoporous silica     sulfonic acid     biodiesel     esterification     oleic acid    

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Amino acid promoted hydrogen battery system using Mn-pincer complex for reversible CO hydrogenation toformic acid

Frontiers in Energy 2022, Volume 16, Issue 5,   Pages 697-699 doi: 10.1007/s11708-022-0843-7

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Discovery of novel ursolic acid derivatives as effective antimicrobial agents through a ROS-mediated

Frontiers of Chemical Science and Engineering   Pages 2101-2113 doi: 10.1007/s11705-023-2361-5

Abstract: In this study, we prepared three series of ursolic acid derivatives and assessed their antibacterialredox system of phytopathogenic bacteria, further demonstrating the unprecedented potential of ursolic acid

Keywords： ursolic acid     antibacterial activities     reactive oxygen species     apoptosis    

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Enzyme@bismuth-ellagic acid: a versatile platform for enzyme immobilization with enhanced acid-base stability

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 6,   Pages 784-794 doi: 10.1007/s11705-022-2278-4

Abstract: biocatalysts; however, it is limited by the conditions of metal–organic framework synthesis and its acid-baseHerein, a biocatalytic platform with improved acid-base stability was constructed via a one-pot methodusing bismuth-ellagic acid as the carrier.Bismuth-ellagic acid is a green phenol-based metal–organic framework whose organic precursor is extractedacid was enhanced, which remained stable over a wide pH range (2–12) and achieved multiple recycling

Keywords： bismuth-ellagic acid     in situ encapsulation     enzyme@MOF biocomposites    

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DNA alkylation promoted by an electron-rich quinone methide intermediate

Chengyun Huang,Steven E. Rokita

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 213-221 doi: 10.1007/s11705-015-1541-3

Abstract: been limited by the slow exchange of their covalent self-adducts and subsequent alkylation of target nucleic

Keywords： methide     DNA alkylation     reversible covalent reaction     bioconjugation     target-directed modification of nucleic    

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Title Author Date Type Operation

Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleicacid drugs: learning from virus

Vaibhav Mundra, Ram I. Mahato

Journal Article

Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Journal Article

Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Journal Article

Validation of polarizable force field parameters for nucleic acids by inter-molecular interactions

Liaoran Cao,Hong Ren,Jing Miao,Wei Guo,Yan Li,Guohui Li

Journal Article

Nucleic acid-based diagnostics for infectious diseases in public health affairs

Albert Cheung-Hoi Yu, Greg Vatcher, Xin Yue, Yan Dong, Mao Hua Li, Patrick H. K. Tam, Parker Y.L. Tsang, April K.Y. Wong, Michael H.K. Hui, Bin Yang, Hao Tang, Lok-Ting Lau

Journal Article

Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Journal Article

Flow cytometric assessment of the effects of chlorine, chloramine, and UV on bacteria by using nucleicacid stains and 5-cyano-2,3-ditolyltetrazolium chloride

Xuebiao Nie, Wenjun Liu, Mo Chen, Minmin Liu, Lu Ao

Journal Article

Li Aihua: Development Trends and Suggestions of Nucleic Acid Vaccines (2021-9-3)

15 Oct 2021

Conference Videos

Research Progress in Molecular Identification Technology for Microbial Resources

Zhang Yu, Ma Aijin, Gao Lifen, Peng Hai, Jia Yingmin, Sun Baoguo

Journal Article

Development Strategy of Microbial Safety Industry

Song Zhongjian, Li Man, Hu Liangbin, Wang Chunming, Lu Xi, Liu Kaihui, Zhang Lijia, Yu Yan, Wu Qingping

Journal Article

Sulfonic acid-functionalized mesoporous silica catalyst with different morphology for biodiesel production

Journal Article

Amino acid promoted hydrogen battery system using Mn-pincer complex for reversible CO hydrogenation toformic acid

Journal Article

Discovery of novel ursolic acid derivatives as effective antimicrobial agents through a ROS-mediated

Journal Article

Enzyme@bismuth-ellagic acid: a versatile platform for enzyme immobilization with enhanced acid-base stability

Journal Article

DNA alkylation promoted by an electron-rich quinone methide intermediate

Chengyun Huang,Steven E. Rokita

Journal Article