Resource Type

Journal Article 26

Conference Videos 1

Year

2024 1

2023 1

2022 3

2021 2

2019 1

2018 6

2017 2

2015 5

2013 2

2012 1

2010 1

open ︾

Keywords

obesity 17

Obesity 3

energy expenditure 3

insulin resistance 3

beige adipocyte 2

body mass index 2

brown adipose tissue 2

nonalcoholic fatty liver disease 2

type 2 diabetes 2

2-Hydroxybutyric acid 1

AMPK 1

Adipocytes 1

Adipogenesis 1

Astragalus 1

Diabetes 1

Fatty liver disease 1

Functional metabolomics 1

Gasotransmitter 1

Glucose 1

open ︾

Search scope:

排序： Display mode:

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

Frontiers of Medicine doi: 10.1007/s11684-023-1003-0

Abstract: mutation (NM_001301860: p.1835A>T/p.D612V) of Lipin3 in a large family with hypertriglyceridemia (HTG) and obesityWe found that Lipin3-heKO mice exhibited obvious obesity, HTG, and non-alcoholic fatty liver disorderOur study suggested that Lipin3 was a novel disease-causing gene inducing obesity and HTG.

Keywords： Lipin3     Lipin1     hypertriglyceridemia     obesity     mitochondrial dysfunction    

HTML PDF Collect

New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 17-24 doi: 10.1007/s11684-021-0873-2

Abstract: Obesity is an important risk factor of type 2 diabetes (T2D), which has become an important factor threateningHowever, no perfect drug choice for obesity exists.This review summarizes clinical evidence of the semaglutide effect on T2D and obesity and establishesexpectations on future clinical trials for obesity treatment.

Keywords： semaglutide     type 2 diabetes     obesity    

HTML PDF Collect

Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 139-145 doi: 10.1007/s11684-015-0377-z

Abstract:

In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissueIn the anti-obesity effects of IL-15, T cells and NK cells are not required, but leptin receptor is requiredsupports that the pro-inflammatory cytokine IL-15 may enhance energy expenditure to protect the body from obesity

Keywords： inflammation     obesity     cytokine     energy expenditure     insulin resistance    

HTML PDF Collect

Early-life famine exposure, adulthood obesity patterns, and risk of low-energy fracture

Frontiers of Medicine doi: 10.1007/s11684-023-1023-9

Abstract: the risk of osteoporosis, but the association of early-life undernutrition combined with adulthood obesityGeneral obesity was assessed using the body mass index (BMI), and abdominal obesity was evaluated withSignificant interactions were observed between fetal famine exposure and general obesity with fractureand WHR, the group of women who underwent fetal famine exposure and had both general and abdominal obesityThese results indicate that early-life famine exposure interacts with adulthood general obesity and significantly

Keywords： famine     obesity     body mass index     waist-to-hip ratio     low-energy fracture    

HTML PDF Collect

Interplay between diet and genetic susceptibility in obesity and related traits

Tiange Wang, Min Xu, Yufang Bi, Guang Ning

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 601-607 doi: 10.1007/s11684-018-0648-6

Abstract:

The incidence of obesity has been rapidly increasing, and this condition has become a major publicenvironmental factors and lifestyle, such as unhealthy diet, is among the major driving forces of the global obesityLongitudinal studies and randomized intervention trials have shown that genetic susceptibility to obesitymay interact with dietary factors in relation to the body mass index and risk of obesity.

Keywords： diet     genetic susceptibility     obesity     interaction    

HTML PDF Collect

Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 146-161 doi: 10.1007/s11684-014-0373-8

Abstract:

Obesity prevalence has increased in recent years.Lifestyle change fuels obesity, but genetic factors cause more than 50% of average variations in obesityThe advent of genome-wide association studies (GWAS) has hastened the progress of polygenic obesity researchin the mechanism of obesity remains unclear.on obesity are needed.

Keywords： obesity     genetics     genome-wide association studies     body mass index     fat mass- and obesity-associated gene    

HTML PDF Collect

Mechanism of insulin resistance in obesity: a role of ATP

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 372-382 doi: 10.1007/s11684-021-0862-5

Abstract: Obesity increases the risk of type 2 diabetes through the induction of insulin resistance.

Keywords： type 2 diabetes     energy expenditure     mitochondria     hyperinsulinemia     hyperglucagonemia     AMPK    

HTML PDF Collect

Epidemic obesity in children and adolescents: risk factors and prevention

Eun Young Lee, Kun-Ho Yoon

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 658-666 doi: 10.1007/s11684-018-0640-1

Abstract: The prevalence of obesity among children and adolescents (aged 2–18 years) has increased rapidly, withMoreover, the epidemic of obesity in this population has been an important public health problem in developedChildhood and adolescent obesity tracks adulthood obesity and has been implicated in many chronic diseasesFurthermore, childhood and adolescent obesity is linked to adulthood mortality and premature death.Many interventional trials for childhood and adolescent obesity have been proven ineffective.

Keywords： obesity     children     adolescents     epidemiology     risk factor     prevention    

HTML PDF Collect

Obesity in China: its characteristics, diagnostic criteria, and implications

Weiping Jia

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 129-133 doi: 10.1007/s11684-015-0387-x

HTML PDF Collect

Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 340-348 doi: 10.1007/s11684-017-0570-3

Abstract:

In light of the rapid increase in the number of obesity incidences worldwide, obesity has become anObesity-related glomerulopathy (ORG) is characterized by glomerulomegaly in the presence or absence ofThese mechanisms synergize with obesity to induce end-stage renal disease.

Keywords： obesity-related glomerulopathy     pathogenesis     pathologic     clinical characteristics    

HTML PDF Collect

Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: anovel model of obesity and puberty

Rahim Ullah, Yan Su, Yi Shen, Chunlu Li, Xiaoqin Xu, Jianwei Zhang, Ke Huang, Naveed Rauf, Yang He, Jingjing Cheng, Huaping Qin, Yu-Dong Zhou, Junfen Fu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 266-276 doi: 10.1007/s11684-017-0530-y

Abstract:

Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatalThe lack of a suitable animal model, however, remains a considerable challenge in obesity studies.We also developed a novel model of C57BL/6J mouse pups with HFD-induced postnatal obesity.Results showed that feeding with HFD induces fat deposition and obesity in pups.Our model suggests good construction validity of obesity and precocious puberty.

Keywords： postnatal HFD feeding     obesity     kisspeptin     HPG axis     precocious puberty    

HTML PDF Collect

Analyzing the distinguishing factors that affect childhood obesity in South Korea

So Jung Yang, Hun-Sung Kim, Kun-Ho Yoon

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 707-716 doi: 10.1007/s11684-018-0660-x

Abstract:

Understanding obesity in children is crucial because it can lead to adulthood obesity and result inDistinctive factors associated with obesity in adults have been described, but distinctive factors relatedOur study revealed that the computing hours in elementary school students with overweight and obesityChildhood obesity can cause depression and reduce children’s quality of life because of their distortedIn conclusion, physical factors directly affecting childhood obesity and psychological and environmental

Keywords： screen time     quality of life     eating habits     childhood obesity     percentage of body mass index    

HTML PDF Collect

Obesity and overweight prevalence and its association with undiagnosed hypertension in Shanghai population

Xinjian Li, Jiying Xu, Haihong Yao, Yanfei Guo, Minna Chen, Wei Lu

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 322-328 doi: 10.1007/s11684-012-0204-8

Abstract: Overweight and obesity prevalence were calculated by the body mass index (BMI) definition recommendedby Working Group on Obesity in China (normal weight, 18.5–23.9 kg/m2; overweight, 24–27.9 kg/m2; obesity,≥28 kg/m2).Multiple logistic regression analyses were used to assess the association of overweight or obesity withThe overall overweight, obesity, and undiagnosed hypertension prevalence were 27.6% (95% CI: 26.8&ndash

Keywords： overweight     obesity     undiagnosed hypertension     prevalence     association    

HTML PDF Collect

Leptin signaling and leptin resistance

Yingjiang Zhou, Liangyou Rui

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 207-222 doi: 10.1007/s11684-013-0263-5

Abstract: Leptin deficiency or genetic defects in the components of the leptin signaling pathways cause obesityLeptin resistance is the key risk factor for obesity.

Keywords： leptin signaling     leptin receptor     energy balance     leptin resistance     obesity    

HTML PDF Collect

The mechanisms linking adiposopathy to type 2 diabetes

Jichun Yang, Jihong Kang, Youfei Guan

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 433-444 doi: 10.1007/s11684-013-0288-9

Abstract:

Obesity is defined as excessive accumulation of body fat in proportion to body size.When obesity occurs, the functions of adipose tissue may be deregulated, which is termed as adiposopathy

Keywords： obesity     adiposopathy     lipotoxicity     adipokines     diabetes    

HTML PDF Collect

Title Author Date Type Operation

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

Journal Article

New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

Journal Article

Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Journal Article

Early-life famine exposure, adulthood obesity patterns, and risk of low-energy fracture

Journal Article

Interplay between diet and genetic susceptibility in obesity and related traits

Tiange Wang, Min Xu, Yufang Bi, Guang Ning

Journal Article

Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Journal Article

Mechanism of insulin resistance in obesity: a role of ATP

Journal Article

Epidemic obesity in children and adolescents: risk factors and prevention

Eun Young Lee, Kun-Ho Yoon

Journal Article

Obesity in China: its characteristics, diagnostic criteria, and implications

Weiping Jia

Journal Article

Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Journal Article

Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: anovel model of obesity and puberty

Rahim Ullah, Yan Su, Yi Shen, Chunlu Li, Xiaoqin Xu, Jianwei Zhang, Ke Huang, Naveed Rauf, Yang He, Jingjing Cheng, Huaping Qin, Yu-Dong Zhou, Junfen Fu

Journal Article

Analyzing the distinguishing factors that affect childhood obesity in South Korea

So Jung Yang, Hun-Sung Kim, Kun-Ho Yoon

Journal Article

Obesity and overweight prevalence and its association with undiagnosed hypertension in Shanghai population

Xinjian Li, Jiying Xu, Haihong Yao, Yanfei Guo, Minna Chen, Wei Lu

Journal Article

Leptin signaling and leptin resistance

Yingjiang Zhou, Liangyou Rui

Journal Article

The mechanisms linking adiposopathy to type 2 diabetes

Jichun Yang, Jihong Kang, Youfei Guan

Journal Article