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oral glucose tolerance test 2

in vivo predictive dissolution 1

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Factors related to compliance with oral analgesic treatment of inpatients with chronic pain

Hong Zhu,Yuzhu Zheng,Hui Gao,Li Liu,Lie Yang

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 374-379 doi: 10.1007/s11684-015-0411-1

Abstract: investigated 100 consecutive inpatients with non-cancer chronic pain who were hospitalized to receive oral, 95%CI: 1.03–3.31, P=0.016) were associated with moderate or non-compliance with oralIn conclusion, the low compliance with oral treatment of analgesics was found in Chinese inpatients with

Keywords： chronic pain     inpatient     oral paregoric drugs     compliance    

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Oral product input to the GI tract: GIS an oral product performance technology

Gordon L. Amidon, Yasuhiro Tsume

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 516-520 doi: 10.1007/s11705-017-1658-7

Abstract: products are formulated with a drug, an active ingredient to produce the maximum therapeutic effect after oralorder to assure the safety and efficacy of pharmaceutical products, we need an predictive tool for oralOral immediate release (IR) dosage forms cannot be optimal for all drugs or likely even any drugs (APIsBut how do we optimize oral delivery of drugs? It is usually through ‘trial and error’, in humans!We need a better way to optimize the oral dosage forms.

Keywords： GIS     in vivo predictive dissolution     ketoconazole     BCS subclassification     supersaturation    

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Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region

Zhiyuan Zhang

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 401-413 doi: 10.1007/s11684-011-0161-7

Abstract: preclinical animal models for bone regeneration and the key translational points to clinical success in oralstrategies based on stem cell and tissue engineering researches, allowing for clinical application in oral

Keywords： bone regeneration     animal models     translational strategies     oral and maxillofacial region    

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Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 9-19 doi: 10.1007/s11705-013-1306-9

Abstract: Oral insulin delivery has received the most attention in insulin formulations due to its high patientHowever, oral insulin delivery has two major limitations: the enzymatic barrier that leads to rapid insulinmajor success in overcoming the mucosal barrier, which is the main cause in undercutting insulin’s oralIn this review of our group’s research, an innovative silica-based, mucoadhesive oral insulin formulationbarriers is discussed, and the preliminary and convincing results to confirm the plausibility of this oral

Keywords： insulin     cell penetrating peptide     mucoadhesive composites     oral delivery    

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Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 815-826 doi: 10.1007/s11684-021-0891-0

Abstract: Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma (BCL)Still, no guidelines or consensus focusing on oral drug therapies for BCL is available.Hematology, Chinese Medical Association conducted an extensive discussion and reached a consensus on oraldrugs for Chinese BCL patients on the basis of the current application status of oral drugs in ChinaThis consensus reviewed the application of oral drugs in the treatment of BCL and the latest research

Keywords： B-cell lymphoma     oral drug     targeted therapy     immunotherapy     COVID-19 pandemic    

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Meta-analysis of the risk factors of breast cancer concerning reproductive factors and oral contraceptive

Qiong DAI MD, Bei LIU MD, Yukai DU MM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 452-458 doi: 10.1007/s11684-009-0080-z

Abstract: authors performed a meta-analysis of case-control studies that addressed whether reproductive factors and oralmenopausal age >50yr [odds ratio (OR), 1.39; 95% confidence interval (CI), 1.22―1.57] and oralMenopausal age >50yr and oral contraceptive use are positively correlated with an increase

Keywords： meta-analysis     breast cancer     risk factors     reproductive factors     oral contraceptive use    

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Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 357-362 doi: 10.1007/s11684-009-0046-1

Abstract: expression of pituitary tumor transforming gene (PTTG) and basic fibroblast growth factor (bFGF) in oral

Keywords： carcinoma     squamous cell     pituitary tumor transforming gene (PTTG) protein     basic fibroblast growth factor    

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A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics

Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,

Engineering doi: 10.1016/j.eng.2023.05.024

Abstract: Thus, DPH endows probiotics with excellent intestine-targeted delivery, improved oral bioavailabilityexhibit almost unchanged bioactivity in the gastrointestinal tract before release, as well as improved oral

Keywords： Polysaccharides     Chitosan     Hydrogels     Oral delivery     Intestine-targeted    

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Oral administration of

Sufen ZHAO,Yuanyuan JIA,Weiwei ZHANG,Lili WANG,Yunfei MA,Kedao TENG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 4,   Pages 318-326 doi: 10.15302/J-FASE-2015080

Abstract: The effects of oral administration of garlic mixture (GM, water-soluble extract) on infectious bursalThe results confirmed the protective effects of oral administration of 5 mg·kg BW GM (Group GM1) onsignificantly increased 7 days post infection in bursae in Group GM1 ( <0.01), suggesting that the oral

Keywords： garlic     infectious bursal disease virus (IBDV)     antiviral effect     IgM-bearing B lymphocyte    

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Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled

Li Ni, Zheng Wen, Xiaowen Hu, Wei Tang, Haisheng Wang, Ling Zhou, Lujin Wu, Hong Wang, Chang Xu, Xizhen Xu, Zhichao Xiao, Zongzhe Li, Chenze Li, Yujian Liu, Jialin Duan, Chen Chen, Dan Li, Runhua Zhang, Jinliang Li, Yongxiang Yi, Wei Huang, Yanyan Chen, Jianping Zhao, Jianping Zuo, Jianping Weng, Hualiang Jiang, Dao Wen Wang

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 704-717 doi: 10.1007/s11684-021-0853-6

Abstract: We conducted a randomized, open-label, parallel-controlled, multicenter trial on the use of Shuanghuanglian (SHL), a traditional Chinese patent medicine, in treating cases of COVID-19. A total of 176 patients received SHL by three doses (56 in low dose, 61 in middle dose, and 59 in high dose) in addition to standard care. The control group was composed of 59 patients who received standard therapy alone. Treatment with SHL was not associated with a difference from standard care in the time to disease recovery. Patients with 14-day SHL treatment had significantly higher rate in negative conversion of SARS-CoV-2 in nucleic acid swab tests than the patients from the control group (93.4% vs. 73.9%, =0.006). Analysis of chest computed tomography images showed that treatment with high-dose SHL significantly promoted absorption of inflammatory focus of pneumonia, which was evaluated by density reduction of inflammatory focus from baseline, at day 7 (mean difference (95% CI), −46.39 (−86.83 to −5.94) HU; =0.025) and day 14 (mean difference (95% CI), −74.21 (−133.35 to −15.08) HU; =0.014). No serious adverse events occurred in the SHL groups. This study illustrated that SHL in combination with standard care was safe and partially effective for the treatment of COVID-19.

Keywords： COVID-19     SARS-CoV-2     Shuanghuanglian oral liquid     clinical trial    

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Anti-hyperglycemic effect of the polysaccharide fraction isolated from mactra veneriformis

Lingchong WANG, Hao WU, Nian CHANG, Kun ZHANG

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 238-244 doi: 10.1007/s11705-010-0002-2

Abstract: Total macromolecule extract was obtained from the soft body of by the coupling techniques of decoction and alcohol precipitation. The extract was deproteinized with an ion exchange column, and resulted in the purifying of the crude polysaccharide fraction. It was found by chemical analysis that the crude polysaccharide part is composed of abundant polysaccharides (>95%) and few proteins (<1%). Furthermore, only one type of monosaccharide, glucose, was detected from its hydrolytes by thin-layer chromatography, indicating that the polysaccharides might be analogs of glucosan. The anti-hyperglycemia effects of the crude polysaccharide part were preliminarily investigated using several pharmacological methods in normal and diabetic mice. Animal experimental results showed that the crude polysaccharide fraction exhibited proper glycemia inhibition activity, and 300 mg/kg-weight dose has the optimal effect among all the studied doses. It is concluded that the crude polysaccharide fraction can be explored as a novel health product that possesses potential as an anti-hyperglycemic agent.

Keywords： anti-hyperglycemia     Mactra veneriformis     polysaccharide     monosaccharide composition     oral    

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Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research and a new co-clinical model for treatment optimization

Shuyang Sun,Zhiyuan Zhang

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 104-110 doi: 10.1007/s11684-016-0432-4

Abstract: bioinformatics have begun to reveal the complex genetic landscape in human cancer genomes, including oral

Keywords： patient-derived xenograft models     personalized medicine     co-clinical trial     patient stratification     oral    

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Pituitary-ovarian hormone and follicular development of various combined oral contraceptives regimens

Huang Pei,Huang Xunbin

Strategic Study of CAE 2015, Volume 17, Issue 6,   Pages 16-20

Abstract:

The combined oral contraceptives (COCs) are combinations of exogenous estrogen and progestin.

Keywords： COCs     HFI     hormone     follicle    

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Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19 in Wuhan

Li Ni, Ling Zhou, Min Zhou, Jianping Zhao, Dao Wen Wang

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 210-214 doi: 10.1007/s11684-020-0757-x

Abstract: treated using the combination of western medicine and Chinese traditional patent medicine Shuanghuanglian oral

Keywords： novel coronavirus (2019-nCoV)     COVID-19     Chinese traditional patent medicine     Shuanghuanglian oral liquid    

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Difference between 2 h and 3 h 75 g glucose tolerance test in the diagnosis of gestational diabetes mellitus (GDM): Results from a national survey on prevalence of GDM

Xue-Lian GAO, Yu-Mei WEI, Hui-Xia YANG, Xian-Ming XU, Ling FAN, Jing HE, Ning LIU, San-Cun ZHAO, Ya-Li HU, Zi YANG, Yun-Ping ZHANG, Xing-Hui LIU, Xu CHEN, Jian-Ping ZHANG, Wen-Li GOU, Mei XIAO, Hai-Rong WU, Mei-Hua ZHANG

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 303-307 doi: 10.1007/s11684-010-0090-x

Abstract: The possibility of the 2 h oral glucose tolerance test (OGTT) as an alternative to the 3 h OGTT was investigated

Keywords： diabetes     gestational     oral glucose tolerance test    

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Title Author Date Type Operation

Factors related to compliance with oral analgesic treatment of inpatients with chronic pain

Hong Zhu,Yuzhu Zheng,Hui Gao,Li Liu,Lie Yang

Journal Article

Oral product input to the GI tract: GIS an oral product performance technology

Gordon L. Amidon, Yasuhiro Tsume

Journal Article

Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region

Zhiyuan Zhang

Journal Article

Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Journal Article

Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Journal Article

Meta-analysis of the risk factors of breast cancer concerning reproductive factors and oral contraceptive

Qiong DAI MD, Bei LIU MD, Yukai DU MM,

Journal Article

Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Journal Article

A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics

Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,

Journal Article

Oral administration of

Sufen ZHAO,Yuanyuan JIA,Weiwei ZHANG,Lili WANG,Yunfei MA,Kedao TENG

Journal Article

Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled

Li Ni, Zheng Wen, Xiaowen Hu, Wei Tang, Haisheng Wang, Ling Zhou, Lujin Wu, Hong Wang, Chang Xu, Xizhen Xu, Zhichao Xiao, Zongzhe Li, Chenze Li, Yujian Liu, Jialin Duan, Chen Chen, Dan Li, Runhua Zhang, Jinliang Li, Yongxiang Yi, Wei Huang, Yanyan Chen, Jianping Zhao, Jianping Zuo, Jianping Weng, Hualiang Jiang, Dao Wen Wang

Journal Article

Anti-hyperglycemic effect of the polysaccharide fraction isolated from mactra veneriformis

Lingchong WANG, Hao WU, Nian CHANG, Kun ZHANG

Journal Article

Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research and a new co-clinical model for treatment optimization

Shuyang Sun,Zhiyuan Zhang

Journal Article

Pituitary-ovarian hormone and follicular development of various combined oral contraceptives regimens

Huang Pei,Huang Xunbin

Journal Article

Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19 in Wuhan

Li Ni, Ling Zhou, Min Zhou, Jianping Zhao, Dao Wen Wang

Journal Article

Difference between 2 h and 3 h 75 g glucose tolerance test in the diagnosis of gestational diabetes mellitus (GDM): Results from a national survey on prevalence of GDM

Xue-Lian GAO, Yu-Mei WEI, Hui-Xia YANG, Xian-Ming XU, Ling FAN, Jing HE, Ning LIU, San-Cun ZHAO, Ya-Li HU, Zi YANG, Yun-Ping ZHANG, Xing-Hui LIU, Xu CHEN, Jian-Ping ZHANG, Wen-Li GOU, Mei XIAO, Hai-Rong WU, Mei-Hua ZHANG

Journal Article