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homoharringtonine 1

oridonin 1

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Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 388-397 doi: 10.1007/s11684-018-0624-1

Abstract: Homoharringtonine (HHT) features activity against tumor cells harboring c-KIT mutations, whereas oridoninTherefore, studies should explore the efficacy of combination therapy with oridonin and HHT in t(8; 21In this study, we investigated the synergistic effects and mechanism of oridonin combined with HHT inenhancing the effects of oridonin.The combination of oridonin and HHT prolonged t(8; 21) leukemia mouse survival.

Keywords: AML1–ETO     c-KIT     homoharringtonine     oridonin     t(8     21) AML     synergistic effect    

Title Author Date Type Operation

Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Journal Article