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Impact of diabetes and its treatments on skeletal diseases

Wenbo Yan, Xin Li

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 81-90 doi: 10.1007/s11684-013-0243-9

Abstract: diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are associated with an increased risk of osteoporosis

Keywords: diabetes     bone     osteoporosis     osteoarthritis    

-Derived miR162a Functions on Osteoporosis Through Directly Promoting Osteoblast Formation

Chunyan Gu,Xichao Yu,Xiaozhu Tang,Leilei Gong,Jingquan Tan,Yuanjiao Zhang,Huili Zheng,Ze Wang,Chenqian Zhang,Yejin Zhu,Zuojian Zhou,Heming Yu,Kai Xu,Jinao Duan,Xiaosong Gu,Ye Yang,

Engineering doi: 10.1016/j.eng.2023.09.007

Abstract: For example, Lycium barbarum L. has been proven to be effective in treating osteoporosis for thousandspromoted osteogenic differentiation in bone marrow mesenchymal stem cells, zebrafish, and a mouse model of osteoporosisphosphatase staining confirmed that transgenic N. benthamiana leaves effectively protected against osteoporosisOur study mechanistically explains how Lycium barbarum L. improves osteoporosis and supports that Lyciumthe bone. miR162a expressed by transgenic plants may represent a novel and safe treatment for human osteoporosis

Keywords: Traditional Chinese medicine     Lycium barbarum     L     miR162a     Osteoporosis     Nuclear receptor corepressor     Transgenic    

Medical applications of phytoestrogens from the Thai herb

Suchinda Malaivijitnond

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 8-21 doi: 10.1007/s11684-012-0184-8

Abstract:

Pueraria mirifica Airy Shaw et Suvatabandhu is a medicinal plant endemic to Thailand. It has been used in Thai folklore medicine for its rejuvenating qualities in aged women and men for nearly one hundred years. Indeed, it has been claimed that P. mirifica contains active phytoestrogens (plant substances with estrogen-like activity). Using high performance liquid chromatography, at least 17 phytoestrogens, mainly isoflavones, have been isolated. Thus, fairly considerable scientific researches, both in vitro in cell lines and in vivo in various species of animals including humans, have been conducted to date to address its estrogenic activity on the reproductive organs, bones, cardiovascular diseases and other climacteric related symptoms. The antioxidative capacity and antiproliferative effect on tumor cell lines have also been assessed. In general, P. mirifica could be applicable for preventing, or as a therapeutic for, the symptoms related to estrogen deficiency in menopausal women as well as in andropausal men. However, the optimal doses for each desirable effect and the balance to avoid undesired side effects need to be calculated before use.

Keywords: white Kwao Krua     miroestrol     estrogenic activity     reproduction     osteoporosis     breast cancer     Alzheimer    

Hybrid deep learning model for risk prediction of fracture in patients with diabetes and osteoporosis

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 496-506 doi: 10.1007/s11684-021-0828-7

Abstract: In addition, the fracture risk of patients with diabetes and osteoporosis has not been further studiedXGBoost with deep neural network is used to predict the fracture risk of patients with diabetes and osteoporosis

Keywords: XGBoost     deep neural network     healthcare     risk prediction    

Mechanisms of “kidney governing bones” theory in traditional Chinese medicine

Dahong Ju,Meijie Liu,Hongyan Zhao,Jun Wang

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 389-393 doi: 10.1007/s11684-014-0362-y

Abstract: nonselective regulation of the NIN during kidney reinforcement therapy, which can be used to treat osteoporosiswherein lipocytes in the bone marrow increase whereas other cells decrease, serves as the pathogenesis of osteoporosiswhole system itself, which explains the kidney-reinforcing effect of many herbs; some herbs can treat osteoporosis

Keywords: kidney governing bones     kidney deficiency     marrow     osteoporosis     neuroendocrine-immune network     osteoclast    

Title Author Date Type Operation

Impact of diabetes and its treatments on skeletal diseases

Wenbo Yan, Xin Li

Journal Article

-Derived miR162a Functions on Osteoporosis Through Directly Promoting Osteoblast Formation

Chunyan Gu,Xichao Yu,Xiaozhu Tang,Leilei Gong,Jingquan Tan,Yuanjiao Zhang,Huili Zheng,Ze Wang,Chenqian Zhang,Yejin Zhu,Zuojian Zhou,Heming Yu,Kai Xu,Jinao Duan,Xiaosong Gu,Ye Yang,

Journal Article

Medical applications of phytoestrogens from the Thai herb

Suchinda Malaivijitnond

Journal Article

Hybrid deep learning model for risk prediction of fracture in patients with diabetes and osteoporosis

Journal Article

Mechanisms of “kidney governing bones” theory in traditional Chinese medicine

Dahong Ju,Meijie Liu,Hongyan Zhao,Jun Wang

Journal Article