Resource Type

Journal Article 13

Year

2022 1

2021 1

2019 2

2018 2

2017 1

2016 1

2014 1

2009 2

2007 2

open ︾

Keywords

platelet 3

Staphylococcus aureus 1

Bacterial toxins 1

Btk inhibitor 1

EPR effect 1

GP I bα 1

Nanoparticle 1

Nanosponge 1

Platelet 1

Raman spectroscopy 1

Sepsis 1

abivertinib 1

anodic arc discharge 1

anti- 1

anti-platelet adhesion 1

anti-β2GP I /β2GP I complex 1

apoER2' 1

bio-inspired 1

biomaterials 1

open ︾

Search scope:

排序： Display mode:

Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 416-428 doi: 10.1007/s11684-021-0838-5

Abstract: of megakaryopoiesis, we speculate that abivertinib can affect megakaryocyte (MK) differentiation and plateletobserved megakaryopoiesis to determine the biological effect of abivertinib on MK differentiation and plateletWe also demonstrated in vivo that abivertinib decreased the number of MKs in bone marrow and plateletthese preclinical data collectively suggested that abivertinib could inhibit MK differentiation and platelet

Keywords： abivertinib     Btk inhibitor     platelet     megakaryocyte     megakaryopoiesis     thrombopoiesis    

HTML PDF Collect

Platelet-rich plasma: combinational treatment modalities for musculoskeletal conditions

Isabel Andia, Michele Abate

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 139-152 doi: 10.1007/s11684-017-0551-6

Abstract: Platelet-rich plasma therapies have emerged as a potential approach to enhance tissue repair and regenerationPlatelet-rich plasma application aims to provide supraphysiological concentrations of platelets and optionallyHowever, the efficacy of platelet-rich plasma is controversial in chronic diseases because patients&rsquoIn this review, the interactions between platelet-rich plasma and healing mechanisms were addressed andThe development of combinational platelet-rich plasma treatments that can be used safely and effectively

Keywords： regenerative medicine     joint conditions     muscle injuries     platelet rich plasma     tendinopathy     healing mechanisms    

HTML PDF Collect

Engineering platelet-mimicking drug delivery vehicles

Quanyin Hu, Hunter N. Bomba, Zhen Gu

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 624-632 doi: 10.1007/s11705-017-1614-6

Abstract: Recreating the specific biological features of platelets by mimicking the structure of the platelet ortranslocating the platelet membrane to synthetic particles holds great promise in disease treatment.This review highlights recent advancements made in the platelet-mimicking strategies.

Keywords： drug delivery     platelets     nanomedicine     bio-inspired     biomimetic    

HTML PDF Collect

Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 667-677 doi: 10.1007/s11684-017-0583-y

Abstract: understanding of the role of platelets in cancer progression and metastasis provides promising approaches for plateletbiomimetic drug delivery systems and functional platelet-targeting strategies for effective cancer treatmentThis review highlights recent progresses in platelet membrane-based drug delivery and unique strategies

Keywords： platelet-mimicking delivery systems     tumor-associated platelets     cancer therapy     EPR effect    

HTML PDF Collect

The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 447-451 doi: 10.1007/s11684-009-0082-x

Abstract: This paper is aimed to examine if changes in platelet-derived growth factor (PDGF) expression at different

Keywords： cervical cancer     lymphatic vessel density     blood vessel density     platelet-derived growth factor    

HTML PDF Collect

Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 76-84 doi: 10.1007/s11684-015-0426-7

Abstract: of anti-β2GP I antibodies in complexes with β2GP I as mediators of plateletinvolvement of the apolipoprotein E receptor 2' (apoER2') and glycoprotein I ba (GP I bα) in plateletPlatelet activation was assessed by measuring GP II b/ III a activation and P-selectin expression andResults showed that the anti-β2GP I /β2GP I complex induced platelet

Keywords： anti-β2GP I /β2GP I complex     platelet     GP I bα     apoER2'     thrombosis    

HTML PDF Collect

polycarbonateurethane surface with poly(ethylene glycol) monoacrylate and phosphorylcholine glyceraldehyde for anti-platelet

Jing YANG,Juan LV,Bin GAO,Li ZHANG,Dazhi YANG,Changcan SHI,Jintang GUO,Wenzhong LI,Yakai FENG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2,   Pages 188-196 doi: 10.1007/s11705-014-1414-1

Abstract: Poly(ethylene glycol) monoacrylate (PEGMA) is grafted onto polycarbonateurethane (PCU) surface via ultraviolet initiated photopolymerization. The hydroxyl groups of poly(PEGMA) on the surface react with one NCO group of isophorone diisocyanate (IPDI) and another NCO group of IPDI is then hydrolyzed to form amino terminal group, which is further grafted with phosphorylcholine glyceraldehyde to establish a biocompatible hydrophilic structure on the surface. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirm the successful grafting of both PEG and phosphorylcholine functional groups on the surface. The decrease of the water contact angle for the modified film is caused by synergic effect of PEG and phosphorylcholine, which both have the high hydrophilicity. Furthermore, the number of platelets adhered is relative low on the synergetically modified PCU film compared with the PCU film modified only by poly(PEGMA). Our synergic modification method using both PEG and phosphorylcholine may be applied in surface modification of blood-contacting biomaterials and some relevant devices.

Keywords： poly(ethylene glycol) monoacrylate     phosphorylcholine     polycarbonateurethane     surface modification     anti-platelet    

HTML PDF Collect

The change of serum leptin and its relationship with platelet membrane glycoprotein Ib in patients with

XIA Dasheng, SONG Yanqiu, LI Chao, ZHANG Feng, WEI Minxin

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 352-355 doi: 10.1007/s11684-007-0067-6

Abstract: The aim of this paper was to investigate the change of serum leptin and its relationship with plateletThe positive percentage and the average fluorescence intensity of platelet membrane GP Ib were detectedThe positive percentage and the average fluorescence intensity of platelet membrane GP Ib in the CHDin CHD patients was independently negatively correlated with the average fluorescence intensity of plateletThe increase of serum leptin could affect blood platelet activation.
HTML PDF Collect

Expression of protease-activated receptors on platelets in healthy individuals

Rui ZHU, Lin SHEN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 236-239 doi: 10.1007/s11684-009-0040-7

Abstract: Fasting venous blood (5 mL) was taken from the medial cubital vein in each individual and platelet-rich

Keywords： protease-activated receptors     platelet    

HTML PDF Collect

Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor

GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 248-252 doi: 10.1007/s11684-007-0047-x

Abstract: to investigate the role of p38 mitogen-activated protein kinase (MAPK) in cell migration induced by platelet-derived

Keywords： control     stimulation     mitogen-activated     growth factor     process    

HTML PDF Collect

Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via

Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 680-689 doi: 10.1007/s11684-018-0673-5

Abstract: Furthermore, SB203580 inhibits anti- GPI/ GPI complex-induced platelet activation.

Keywords： anti-   

HTML PDF Collect

Engineered Biomimetic Platelet Membrane-Coated Nanoparticles Block Staphylococcus aureus Cytotoxicity Article

Jwa-Kyung Kim, Satoshi Uchiyama, Hua Gong, Alexandra Stream, Liangfang Zhang, Victor Nizet

Engineering 2021, Volume 7, Issue 8,   Pages 1149-1156 doi: 10.1016/j.eng.2020.09.013

Abstract: Here, we examine the use of human platelet membrane-coated nanoparticles (PNPs) as a biomimetic decoyThe PNPs blocked platelet damage induced by S. aureus secreted toxins, thereby supporting platelet

Keywords： Nanoparticle     Nanosponge     Platelet     Staphylococcus aureus     Bacterial toxins     Sepsis    

HTML PDF Collect

Plasma-enabled healing of graphene nano-platelets layer

Xiuqi Fang, Carles Corbella, Denis B. Zolotukhin, Michael Keidar

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 2,   Pages 350-359 doi: 10.1007/s11705-018-1787-7

Abstract: Graphene platelet networks (GPNs) were deposited onto silicon substrates by means of anodic arc discharge

Keywords： graphene platelet networks     anodic arc discharge     plasma healing     scanning electron microscopy     Raman spectroscopy    

HTML PDF Collect

Title Author Date Type Operation

Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis

Journal Article

Platelet-rich plasma: combinational treatment modalities for musculoskeletal conditions

Isabel Andia, Michele Abate

Journal Article

Engineering platelet-mimicking drug delivery vehicles

Quanyin Hu, Hunter N. Bomba, Zhen Gu

Journal Article

Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

Journal Article

The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

Journal Article

Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Journal Article

polycarbonateurethane surface with poly(ethylene glycol) monoacrylate and phosphorylcholine glyceraldehyde for anti-platelet

Jing YANG,Juan LV,Bin GAO,Li ZHANG,Dazhi YANG,Changcan SHI,Jintang GUO,Wenzhong LI,Yakai FENG

Journal Article

The change of serum leptin and its relationship with platelet membrane glycoprotein Ib in patients with

XIA Dasheng, SONG Yanqiu, LI Chao, ZHANG Feng, WEI Minxin

Journal Article

Expression of protease-activated receptors on platelets in healthy individuals

Rui ZHU, Lin SHEN

Journal Article

Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor

GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong

Journal Article

Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via

Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu

Journal Article

Engineered Biomimetic Platelet Membrane-Coated Nanoparticles Block Staphylococcus aureus Cytotoxicity

Jwa-Kyung Kim, Satoshi Uchiyama, Hua Gong, Alexandra Stream, Liangfang Zhang, Victor Nizet

Journal Article

Plasma-enabled healing of graphene nano-platelets layer

Xiuqi Fang, Carles Corbella, Denis B. Zolotukhin, Michael Keidar

Journal Article