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Do not let precision medicine be kidnapped

Zhiping Yang

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 512-513 doi: 10.1007/s11684-015-0425-8

Abstract:

Obama’s precision medicine initiative made the medical community boil over after the initiativePrecision medicine has been advocated by the majority of scientists and doctors.This article does not oppose precision medicine.However, the incentive of vigorously promoting precision medicine at present is a concern.

Keywords: precision medicine     personalized medicine     genomics    

Review on the progress of ultra-precision machining technologies

Julong YUAN, Binghai LYU, Wei HANG, Qianfa DENG

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 2,   Pages 158-180 doi: 10.1007/s11465-017-0455-9

Abstract:

Ultra-precision machining technologies are the essential methods, to obtain the highest form accuracyThe conception, applications and history of ultra-precision machining are introduced in this article,and the developments of ultra-precision machining technologies, especially ultra-precision grinding,ultra-precision cutting and polishing are also reviewed.

Keywords: ultra-precision grinding     ultra-precision cutting     ultra-precision polishing     research status in China     development    

Self-generation of machining precision and its realization in lapping of super precision solid balls

ZHANG Bopeng

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 3,   Pages 348-353 doi: 10.1007/s11465-008-0065-7

Abstract: This paper presents the principle of self-generation of machining precision by explaining its basic conceptThe self-generation of machining precision for solid balls with super precision is emphatically explainedNecessary conditions for achieving self-generation of machining precision are given.Establishment of the system for machining solid balls with super precision is discussed.Self-generation of machining precision for solid balls with super precision on the basis of the capability

Keywords: self-generation     necessary     self-regulation capability     viewpoint     Necessary    

Human pangenome: far-reaching implications in precision medicine

Frontiers of Medicine doi: 10.1007/s11684-023-1039-1

Abstract: Human pangenome: far-reaching implications in precision medicine

Highlights in precision agriculture

Chunjiang ZHAO, Minzan LI

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 4,   Pages 391-392 doi: 10.15302/J-FASE-2018246

High resolution satellite imaging sensors for precision agriculture

Chenghai YANG

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 4,   Pages 393-405 doi: 10.15302/J-FASE-2018226

Abstract:

The central concept of precision agriculture is to manage within-field soil and crop growth variabilityRemote sensing has been an integral part of precision agriculture since the farming technology startedagricultural applications over large geographic areas since the 1970s, but they have limited use for precisionaerial coverage, make high resolution satellite sensors attractive for many applications, including precisionThe applications of these sensors for precision agriculture are reviewed and application examples based

Keywords: high resolution satellite sensor     multispectral imagery     precision agriculture     spatial resolution     temporal    

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract:

On May 23, 2017, the US Food and Drug Administration (FDA) approved a treatment for cancer patients with positive microsatellite instability-high (MSI-H) markers or mismatch repair deficient (dMMR) markers. This approach is the first approved tumor treatment using a common biomarker rather than specified tumor locations in the body. FDA previously approved Keytruda for treatment of several types of malignancies, such as metastatic melanoma, metastatic non-small-cell lung cancer, recurrent or metastatic head and neck cancer, refractory Hodgkin lymphoma, and urothelial carcinoma, all of which carry positive programmed death-1/programmed death-ligand 1 biomarkers. Therefore, indications of Keytruda significantly expanded. Several types of malignancies are disclosed by MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune response in tumor microenvironment, including portions of colorectal and gastric carcinomas. Currently, biomarker-based patient selection remains a challenge. Pathologists play important roles in evaluating histology and biomarker results and establishing detection methods. Taking gastric cancer as an example, its molecular classification is built on genome abnormalities, but it lacks acceptable clinical characteristics. Pathologists are expected to act as “genetic interpreters” or “genetic translators” and build a link between molecular subtypes with tumor histological features. Subsequently, by using their findings, oncologists will carry out targeted therapy based on molecular classification.

Keywords: molecular classification     precision medicine     pembrolizumab     PD-1/PD-L1     MSI-H    

ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 540-546 doi: 10.1007/s11684-018-0637-9

Abstract: Given the rapid development in precision medicine, tremendous efforts have been devoted to discoveringcell membrane upon activation and detected in liquid biopsy, thus offering considerable potential in precisionThe future perspectives of ECRG4 as a potential molecular marker in precision medicine are also discussed

Keywords: ECRG4     tumor suppressor gene     sentinel molecule     precision medicine     cell senescence     epithelium homeostasis    

Application of liquid biopsy in precision medicine: opportunities and challenges

Junyun Wang, Shuang Chang, Guochao Li, Yingli Sun

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 522-527 doi: 10.1007/s11684-017-0526-7

Abstract:

Precision medicine for cancer patients aims to adopt the most suitable treatment options during diagnosisThey could also provide the ideal scheme to personalize treatment in precision medicine.

Keywords: liquid biopsy     circulating tumor cells     cell-free ctDNA     exosomes     precision medicine    

Special issue: Ultra-precision machining

Zhuangde JIANG,Dongming GUO

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 1,   Pages 1-2 doi: 10.1007/s11465-017-0445-y

Development and application prospects of piezoelectric precision driving technology

ZHAO Chunsheng, ZHANG Jiantao, ZHANG Jianhui, JIN Jiamei

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 2,   Pages 119-132 doi: 10.1007/s11465-008-0034-1

Abstract: science and technology, microelectronics manufacturing, photonics technology, space technology, ultra-precisionmachining, micro-robotics, biomedical engineering and other fields urgently need the support of modern precisionModern precision driving technology can be generally divided into two parts: electromagnetic and non-electromagneticThis paper presents the development of piezoelectric precision driving technology at home and abroadmanipulation and assembly technology; 4) biomedical engineering; 5) aerospace technology; and 6) ultra-precision

Keywords: Electromagnetic     ultra-precision processing     technology     piezoelectric     cumbrous    

Research progress on ultra-precision machining technologies for soft-brittle crystal materials

Hang GAO,Xu WANG,Dongming GUO,Yuchuan CHEN

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 1,   Pages 77-88 doi: 10.1007/s11465-017-0411-8

Abstract:

Soft-brittle crystal materials are widely used in many fields, especially optics and microelectronics. However, these materials are difficult to machine through traditional machining methods because of their brittle, soft, and anisotropic nature. In this article, the characteristics and machining difficulties of soft-brittle and crystals are presented. Moreover, the latest research progress of novel machining technologies and their applications for soft-brittle crystals are introduced by using some representative materials (e.g., potassium dihydrogen phosphate (KDP), cadmium zinc telluride (CZT)) as examples. This article reviews the research progress of soft-brittle crystals processing.

Keywords: brittle     soft     functional crystal     ultra-precision machining    

A hybrid deep learning model for robust prediction of the dimensional accuracy in precision milling of

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 3, doi: 10.1007/s11465-022-0688-0

Abstract: In this study, we develop a predictive model of the dimensional accuracy for precision milling of thin-walledcomponent—squares, slots, and holes—into various categories based on their dimensional errors (i.e., “high precision

Keywords: precision milling     dimensional accuracy     cutting force     convolutional neural networks     coherent noise    

Gray-box modeling and QFT control for precision servo transmission systems

Xiulan BAO, Xuedong CHEN, Xin LUO, Haocheng ZUO

Frontiers of Mechanical Engineering 2011, Volume 6, Issue 4,   Pages 442-448 doi: 10.1007/s11465-011-0242-y

Abstract:

Precision servo transmission systems have widely been applied in industrial equipment to achieve highHowever, due to the presence of friction and uncertainty, the characteristics of precision servo transmissionThis paper proposes two-degrees of freedom (2-DOF) robust position controller for a precision servo transmission

Keywords: precision servo transmission system     modeling     set membership identification     quantitative feedback theory    

Improving retrieval precision of NO

Jinpeng YANG

Frontiers of Mechanical Engineering 2009, Volume 4, Issue 1,   Pages 92-96 doi: 10.1007/s11465-009-0001-5

Abstract: The NO density error retrieved by the traditional method of differential optical absorption spectroscopy (DOAS) was analyzed. The technique for reducing the error is proposed and used to obtain the NO density of Chengdu through DOAS.

Keywords: absorption structure     low-frequency structure     absorption cross-section     NO2 density    

Title Author Date Type Operation

Do not let precision medicine be kidnapped

Zhiping Yang

Journal Article

Review on the progress of ultra-precision machining technologies

Julong YUAN, Binghai LYU, Wei HANG, Qianfa DENG

Journal Article

Self-generation of machining precision and its realization in lapping of super precision solid balls

ZHANG Bopeng

Journal Article

Human pangenome: far-reaching implications in precision medicine

Journal Article

Highlights in precision agriculture

Chunjiang ZHAO, Minzan LI

Journal Article

High resolution satellite imaging sensors for precision agriculture

Chenghai YANG

Journal Article

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Journal Article

ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Journal Article

Application of liquid biopsy in precision medicine: opportunities and challenges

Junyun Wang, Shuang Chang, Guochao Li, Yingli Sun

Journal Article

Special issue: Ultra-precision machining

Zhuangde JIANG,Dongming GUO

Journal Article

Development and application prospects of piezoelectric precision driving technology

ZHAO Chunsheng, ZHANG Jiantao, ZHANG Jianhui, JIN Jiamei

Journal Article

Research progress on ultra-precision machining technologies for soft-brittle crystal materials

Hang GAO,Xu WANG,Dongming GUO,Yuchuan CHEN

Journal Article

A hybrid deep learning model for robust prediction of the dimensional accuracy in precision milling of

Journal Article

Gray-box modeling and QFT control for precision servo transmission systems

Xiulan BAO, Xuedong CHEN, Xin LUO, Haocheng ZUO

Journal Article

Improving retrieval precision of NO

Jinpeng YANG

Journal Article