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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 503-517 doi: 10.1007/s11684-022-0947-9

Abstract: Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCC) tissues. We previously showed that ALDOB inhibited proliferation through a mechanism independent of its enzymatic activity in ccRCC, but the mechanism was not unequivocally identified. We showed that the corepressor C-terminal-binding protein 2 (CtBP2) is a novel ALDOB-interacting protein in ccRCC. The CtBP2-to-ALDOB expression ratio in clinical samples was correlated with the expression of CtBP2 target genes and was associated with shorter survival. ALDOB inhibited CtBP2-mediated repression of multiple cell cycle inhibitor, proapoptotic, and epithelial marker genes. Furthermore, ALDOB overexpression decreased the proliferation and migration of ccRCC cells in an ALDOB-CtBP2 interaction-dependent manner. Mechanistically, our findings showed that ALDOB recruited acireductone dioxygenase 1, which catalyzes the synthesis of an endogenous inhibitor of CtBP2, 4-methylthio 2-oxobutyric acid. ALDOB functions as a scaffold to bring acireductone dioxygenase and CtBP2 in close proximity to potentiate acireductone dioxygenase-mediated inhibition of CtBP2, and this scaffolding effect was independent of ALDOB enzymatic activity. Moreover, increased ALDOB expression inhibited tumor growth in a xenograft model and decreased lung metastasis in vivo. Our findings reveal that ALDOB is a negative regulator of CtBP2 and inhibits tumor growth and metastasis in ccRCC.

Keywords: ALDOB     kidney cancer     cell proliferation    

Lateral progression of brachial plexus avulsion injury

GU Yudong

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 20-23 doi: 10.1007/s11684-007-0004-8

Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 33-40 doi: 10.1007/s11684-016-0431-5

Abstract: number of recent studies have analyzed the contribution of cancer microenvironment to the initiation and progression

Keywords: cancer-associated fibroblast     breast cancer     progression     prognosis    

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11684-009-0006-9

Abstract: The interaction by co-stimulatory molecules 4-1BB and 4-1BB ligand (4-1BBL) plays an important role in the activation, proliferation and differentiation of T lymphocytes. The function of 4-1BB/4-1BBL expressed by the immune cells has been the focus for many tumor immunotherapy efforts. In this study, 4-1BBL was expressed in non-immune cells and non-tumor cells, and the role of 4-1BBL in lymphocyte activation and tumor suppression was investigated. The plasmid p4-1BBL containing the full length of mouse 4-1BBL cDNA sequence was constructed, and the plasmid was transfected into baby hamster kidney (BHK) cells and murine muscle cells by means of lipofectin-mediated or naked plasmid DNA injection into the muscle directly. The study demonstrated that the molecule 4-1BBL expressed by BHK cells could enhance the proliferation and cytotoxicity of lymphocytes, and it could increase the expression level of IL-2 and IFN-γ. The treatment with plasmid p4-1BBL revealed that the number of CD8 T cells in the peri-tumoral tissue increased markedly, and the growth rate of the tumor was significantly lower than that of control group. These findings suggest that expression of 4-1BBL by normal cells in the tumor microenvironment can enhance the proliferation and other functions of T lymphocytes. This therapeutic method may provide a promising approach for tumor immunotherapy.

Keywords: 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

Coronary leukocyte activation in relation to progression of coronary artery disease

Marijke A. de Vries,Arash Alipour,Erwin Birnie,Andrew Westzaan,Selvetta van Santen,Ellen van der Zwan,Anho H. Liem,Noëlle van der Meulen,Manuel Castro Cabezas

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 85-90 doi: 10.1007/s11684-016-0435-1

Abstract: linked to atherogenesis, but there is little in vivo evidence for its role in the progressionWe evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activationDuring follow-up, 13 patients (13%) developed progression of CAD.intracellular MPO measured in blood obtained from the coronary arteries were not associated with the progressionmonocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO do not predict the risk of progression

Keywords: coronary artery disease     inflammation     integrin     myeloperoxidase     leukocyte activation    

5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 476-492 doi: 10.1007/s11684-022-0966-6

Abstract: tRNA-derived small RNAs (tsRNAs) are novel non-coding RNAs that are involved in the occurrence and progression> derived 5′-tiRNA-Gln, is significantly downregulated, and its expression level is correlated with progressiondownregulated proteins include ARAF, MEK1/2 and STAT3, causing the impaired signaling pathway related to HCC progressionthe intramolecular G-quadruplex structure, and this process partially inhibits translation and HCC progression

Keywords: EIF4A1     G-quadruplex     hepatocellular carcinoma     tRNA-derived small RNA     translation initiation    

NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 263-274 doi: 10.1007/s11684-022-0935-0

Abstract: However, the functional significance of NETO2 in melanoma progression remains unclear.Overall, this study uncovered the crucial role of NETO2-mediated regulation in melanoma progression,

Keywords: melanoma     neuropilin and tolloid-like 2     Ca2+/CaMKII signaling pathway    

Effects of 3-aminobenzamide on poly (ADP-ribose) polymerase expression, apoptosis and cell cycle progression

DU Xiang, ZHAO Hongguang, GUO Wei, GONG Shouliang, WANG Wen

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 204-206 doi: 10.1007/s11684-008-0039-5

Abstract: The aim of this paper is to study the changes of apoptosis and cell cycle progression in HeLa cells after(FCM) was used to examine the PARP expression and the percentage of apoptotic cells and cell cycle progression

Keywords: control     irradiation     apoptotic     progression     3-AB    

Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 106-112 doi: 10.1007/s11684-014-0307-5

Abstract: However, the molecular alterations that drive progression and metastasis of cervical cancer remain unclearCellular senescence has been proposed as the mechanism that protects an organism against cancer progressionOur results suggested that the expression of Twist increased during the progression and metastasis of

Keywords: cervical cancer     senescence     Twist     CBX3     lymph node metastasis    

Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the

Frontiers of Medicine   Pages 924-938 doi: 10.1007/s11684-023-1004-z

Abstract: Long noncoding RNAs (lncRNAs) play a crucial regulatory role in the development and progression of multipleCollectively, our results demonstrated that LOC646029 is involved in the progression and metastasis of

Keywords: ovarian cancer     lncRNA LOC646029     metastasis     microRNA 627-3p     SPRED1    

RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 143-155 doi: 10.1007/s11684-022-0929-y

Abstract: studies confirmed that let-7c-5p, a well-known microRNA, can act as a tumour suppressor to regulate the progressionHowever, whether RGS16 can promote the progression of glioma and whether it is regulated by miR let-7cThus, we suggest that the suppression of RGS16 by miR let-7c-5p can promote glioma progression and may

Keywords: RGS16     let-7c-5p     glioma     proliferation     migration    

Fingerprint Spectral Signatures Revealing the Spatiotemporal Dynamics of Bipolaris Spot Blotch Progression Article

Fengle Zhu, Zhenzhu Su, Alireza Sanaeifar, Anand Babu Perumal, Mostafa Gouda, Ruiqing Zhou, Xiaoli Li, Yong He

Engineering 2023, Volume 22, Issue 3,   Pages 171-184 doi: 10.1016/j.eng.2022.10.006

Abstract: Therefore, the dynamic characterization of early pathogen progression is crucial for disease monitoringThe early spectral and biochemical responses of barley leaves to spot blotch progression were also investigatedinterpretable and could capture the unique characteristics of chlorotic and necrotic tissues along with lesion progressionalterations, the extracted FSSs successfully tracked the spatiotemporal dynamics of bipolaris spot blotch progression

Keywords: Hyperspectral imaging     Fingerprint spectral signatures     Spot blotch     Leaf lesion progression     Presymptomatic    

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: in vitro anti-tumor functions of CAR-T cells, leading to CAR-T cell therapy failure and disease progressiontumor microenvironments persisted before CAR-T cell therapy, during both cell expansion and disease progression

Keywords: anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment     tumor-associated macrophage     metabolism    

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 240-262 doi: 10.1007/s11684-022-0936-z

Abstract: Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas

Keywords: glioma progression     molecular classification     EM/PM subtyping     intratumor heterogeneity    

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 714-728 doi: 10.1007/s11684-022-0959-5

Abstract: of the 4.1 ezrin–radixin–moesin domain-containing protein family, has been reported to inhibit tumor progressionHere, we demonstrate the involvement of FRMD6 in lung cancer progression.Altogether, our results show that FRMD6 contributes to lung cancer progression by activating the mTOR

Keywords: FRMD6     lung cancer     mTOR pathway    

Title Author Date Type Operation

Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Journal Article

Lateral progression of brachial plexus avulsion injury

GU Yudong

Journal Article

Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Journal Article

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Journal Article

Coronary leukocyte activation in relation to progression of coronary artery disease

Marijke A. de Vries,Arash Alipour,Erwin Birnie,Andrew Westzaan,Selvetta van Santen,Ellen van der Zwan,Anho H. Liem,Noëlle van der Meulen,Manuel Castro Cabezas

Journal Article

5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction

Journal Article

NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

Journal Article

Effects of 3-aminobenzamide on poly (ADP-ribose) polymerase expression, apoptosis and cell cycle progression

DU Xiang, ZHAO Hongguang, GUO Wei, GONG Shouliang, WANG Wen

Journal Article

Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Journal Article

Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the

Journal Article

RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Journal Article

Fingerprint Spectral Signatures Revealing the Spatiotemporal Dynamics of Bipolaris Spot Blotch Progression

Fengle Zhu, Zhenzhu Su, Alireza Sanaeifar, Anand Babu Perumal, Mostafa Gouda, Ruiqing Zhou, Xiaoli Li, Yong He

Journal Article

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Journal Article

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Journal Article

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Journal Article