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Clustered regularly interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9) 1

Discrete control 1

Epigenetics 1

Forkhead box protein A2 (FOXA2) 1

HepG2 cells 1

Hepatocyte nuclear factor 1 alpha (HNF1A) 1

Hepatocyte nuclear factor 4 alpha (HNF4A) 1

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Sewer system 1

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diabetic kidney disease 1

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Water-level based discrete integrated dynamic control to regulate the flow for sewer-WWTP operation

Zhengsheng Lu, Moran Wang, Mingkai Zhang, Ji Li, Ying Xu, Hanchang Shi, Yanchen Liu, Xia Huang

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 3, doi: 10.1007/s11783-020-1222-4

Abstract: The discretized water level control method can regulate dynamic wastewater pumping flow of pumps followingThe operational results showed that the control method could provide a more stabilized regulate pumping

Keywords： Sewer system     Integrated control     Discrete control     Water level    

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“Composition” and regularisation of architectural production in contemporary China

Hua LI

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 4,   Pages 465-473 doi: 10.1007/s11709-010-0097-z

Abstract: unified whole, but also relates to an array of different “constructions” of architectural knowledge which regulate

Keywords： composition     “Beaux-Arts”     regulate     architectural production    

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Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 293-304 doi: 10.1007/s11684-019-0715-7

Abstract: Netrin-1, an axon guidance factor, and its receptor UNC5B play important roles in axonal development and angiogenesis. This study examined netrin-1 and UNC5B expression in kidneys with diabetic kidney disease (DKD) and investigated their roles in angiogenesis. Netrin-1 and UNC5B were upregulated in streptozotocin-induced DKD Wistar rats, and their expression was compared with that in healthy controls. However, exogenous netrin-1 in UNC5B-depleted human renal glomerular endothelial cells (HRGECs) inhibited cell migration and tubulogenesis. This effect was likely associated with SRC pathway deactivation. Netrin-1 treatment also eliminated the pro-angiogenic effects of exogenous VEGF-165 on UNC5B-silenced HRGECs. These results indicate that UNC5B antagonizes netrin-1 and that UNC5B upregulation contributes partly to enhancing angiogenesis in DKD. Therefore, introducing exogenous netrin-1 and depleting endogenous UNC5B are potential strategies for reducing the incidence of early angiogenesis and mitigating kidney injury in DKD.

Keywords： netrin-1     VEGF-165     UNC5B     angiogenesis     diabetic kidney disease    

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Diverting Seawater to Scour the Estuary and to Regulate the Lower Yellow River

Lin Bingnan,Zhou Jianjun,Zhang Ren

Strategic Study of CAE 2000, Volume 2, Issue 4,   Pages 25-33

Abstract:

The writers propose to divert seawater from Guanli Harbor on the coast of Laizhou Bay with transversal canals and have it discharged into the Lower Yellow River at Lijin, about 110 km upstream of the river mouth (route B, Fig. 1). The flow diverted ranges from 500 to 1 500 m3/s, to be stipulated later in the feasibility study. This flow of “clear” seawater would strongly scour the channel downstream of Lijin and reduce its surface slope so much that for a flood of 3 000 m3/s an abrupt drop of 3.3 to 7.9m in the water surface would occur at Lijin. This drop would bring about retrogressive erosion of the riverbed upstream of the point of injection of seawater. The extent of this erosion is estimated to be 270 km upstream from Lijin. Thus a total of about 380 km of river channel would be scoured down. The reach downstream of Lij in would be transformed from an above - the - ground river to a down - in - the - ground river and the reach above Lijin would possess a deeper main channel. Safety in the defense against flood would thus be much enhanced.

For rational use of the Yellow River water resources, the State Council has allocated definite water right to every riparian province. A runoff of about 20 km3 is, however, to be reserved for sediment transport, in order to prevent the channel bed from excessive silting. With the facility available for the injection of seawater at Lijin, however, in the region down stream of Lijin one may redeem a portion of fresh water so reserved and restored the channel afterwards by scouring with seawater. Depending on capacities of pumping and reservoir storage available, the amount of fresh water redeemed may well run up to 1 km3 annually. This would be very valuable to the development of the estuarine region.

Since 1972, the Lower Yellow River has experienced a dry spell and has dried up from time to time. This has upset the ecological balance of the Bohai Sea because of interruption in the discharge of nutrient - carrying turbid water from the river. Scouring the estuary by diverting seawater will maintain a year round discharge of turbid water to the sea and help improve the ecological conditions as well as checking the receding of the coastline.

Turbid seawater being of greater specific weight than the clear seawater would form density current when discharged to the Bohai Sea. Sediment would then be conveyed to points far from the river mouth, thus delaying or even stopping the extension of the Yellow River delta. Moreover, when the river dries up, the river mouth would most likely recede under the scour of the discharging seawater because of lack of sediment supply from the drainage basin. Taking all the factors into account, one may expect little delta extension when seawater is diverted for scouring. Lijin, where seawater is injected, may then be taken as the effective location of the river mouth where the longitudinal equilibrium profile of the Lower Yellow River would terminate. This equilibrium profile would be lower than the original one by 4～12 m, depending on the estimated values of equilibrium slope for the final reach of the estuary. The hazard of levee breaching is thus much reduced.

Keywords： diverting seawater     scouring     the Lower Yellow River     above-the-ground river     water resources    

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Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation Article

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Engineering 2024, Volume 32, Issue 1,   Pages 58-69 doi: 10.1016/j.eng.2023.09.019

Abstract: nuclear factor 4 alpha (HNF4A), and forkhead box protein A2 (FOXA2) are key transcription factors that regulate

Keywords： Clustered regularly interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9)     Epigenetics     Hepatocyte nuclear factor 1 alpha (HNF1A)     Hepatocyte nuclear factor 4 alpha (HNF4A)     Forkhead box protein A2 (FOXA2)     N-glycosylation     HepG2 cells    

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Title Author Date Type Operation

Water-level based discrete integrated dynamic control to regulate the flow for sewer-WWTP operation

Zhengsheng Lu, Moran Wang, Mingkai Zhang, Ji Li, Ying Xu, Hanchang Shi, Yanchen Liu, Xia Huang

Journal Article

“Composition” and regularisation of architectural production in contemporary China

Hua LI

Journal Article

Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Journal Article

Diverting Seawater to Scour the Estuary and to Regulate the Lower Yellow River

Lin Bingnan,Zhou Jianjun,Zhang Ren

Journal Article

Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Journal Article

Sun Jia: Target Intestinal Flora to Regulate Autoimmune Response（2020.1.10）

孙嘉(高级职称)

23 Jun 2020

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