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Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19
Xiaofang Cai, Hanlan Jiang, Simin Zhang, Shengying Xia, Wenhui Du, Yaoling Ma, Tao Yu, Wenbin Li
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 776-785 doi: 10.1007/s11684-020-0820-7
Keywords: coronavirus disease 2019 pediatrics emergency retrospective investigation severe acute respiratory syndrome
Yun Zhang,Chen Li,Min Shen,Bao Liu,Xuejun Zeng,Ti Shen
Frontiers of Medicine 2017, Volume 11, Issue 1, Pages 62-67 doi: 10.1007/s11684-017-0498-7
Chronic disseminated intravascular coagulation (DIC) is a rare but devastating complication of aortic aneurysm (AA). This study investigated the clinical manifestations, laboratory findings, and treatment of patients with AA-associated chronic DIC (AA-DIC) and explored the mechanisms, duration, and therapeutic response of AA-DIC. We retrospectively reviewed the medical records of 235 AA patients admitted at the Peking Union Medical College Hospital between September 2009 and January 2015. The patients were classified as those with DIC (AA-DIC) and those without DIC (non-DIC). The AA-DIC group showed a significantly higher proportion of female patients and a significantly longer AA disease course than the non-DIC group did. The AA-DIC patients presented mural thrombi, dissecting aneurysms, a family history of AA, and diabetes significantly more frequently than the non-DIC patients did. Furthermore, multiple regression analyses revealed that sex, mural thrombus, aneurysm type, diabetes, and stent surgery are possible independent risk factors for AA-DIC patients. Fifty-two (22.1%) patients presented AA-DIC. Among these patients, 43 had non-typical DIC and 9 had typical DIC; the mortality rate of the latter was 22.2%. The mean age of the patients with typical DIC was significantly higher than of that of patients with non-typical DIC. The non-typical DIC patients also presented abnormal coagulation disorders of varying degrees. Furthermore, heparin or low-molecular-weight heparin improved the clinical symptoms and laboratory parameters in patients with AA and typical DIC. Thus, chronic DIC should be considered in patients with AA.
Keywords: aortic aneurysm disseminated intravascular coagulation anticoagulation therapy
Frontiers of Medicine 2022, Volume 16, Issue 1, Pages 111-125 doi: 10.1007/s11684-021-0854-5
Keywords: COVID-19 chronic hepatitis B liver injury coagulation dysfunction
infections among diarrheal outpatients in Shanghai: a retrospective case study
Yanyan Jiang, Zhongying Yuan, Guoqing Zang, Dan Li, Ying Wang, Yi Zhang, Hua Liu, Jianping Cao, Yujuan Shen
Frontiers of Medicine 2018, Volume 12, Issue 1, Pages 98-103 doi: 10.1007/s11684-018-0614-3
Cyclospora cayetanensis is a foodborne and waterborne pathogen that causes endemic and epidemic human diarrhea worldwide. A few epidemiological studies regarding C. cayetanensis infections in China have been conducted. During 2013, a total of 291 stool specimens were collected from patients with diarrhea at a hospital in urban Shanghai. C. cayetanensis was not detected in any of the stool specimens by traditional microscopy, whereas five stool specimens (1.72%, 5/291) were positive by PCR. These positive cases confirmed by molecular technology were all in the adult group (mean age 27.8 years; 2.94%, 5/170) with watery diarrhea. Marked infection occurred in the rainy season of May and July. Sequence and phylogenetic analyses of the partial 18S rRNA genes of C. cayetanensis isolated showed intra-species diversity of this parasite. This study showed, for the first time, that C. cayetanensis is a pathogen in outpatients with diarrhea in Shanghai, albeit at a low level. However, the transmission dynamics of this parasite in these patients remain uncertain.
Keywords: Cyclospora cayetanensis outpatients with diarrhea stool specimens 18S rRNA gene
Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 91-95 doi: 10.1007/s11684-014-0305-7
A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes and prognostic factors of these patients, particularly those who underwent primary debulking surgery followed by platinum-based chemotherapy. Clinico-pathological parameters, including progression-free survival (PFS) and overall survival (OS), were also analyzed. The median follow-up period from the end of initial treatment to June 2010 was 58 months. The three-year PFS rate was 61.7% for International Federation of Gynecology and Obstetrics (FIGO) I–II, 19.9% for FIGO III–IV, and 33.9% for all stages. By comparison, the five-year PFS rate was 44.6% for FIGO I–II, 17.7% for FIGO III–IV, and 28.3% for all stages. The three-year OS rate was 67.9% for FIGO I–II, 41.7% for FIGO III–IV, and 50.2% for all stages. The five-year OS rate was 52.7% for FIGO I–II, 30.8% for FIGO III–IV, and 39.2% for all stages. Univariate analysis revealed that advanced FIGO stage, serum CA125, and suboptimal debulking were significant factors affecting PFS and OS. In multivariate analysis, PFS was significantly influenced by FIGO stage and suboptimal debulking. However, OS was significantly influenced by advanced FIGO stage only. Our study confirms the efficacy of surgery followed by platinum-based chemotherapy for EOC. FIGO stage is considered as one of the most reliable predictors of the prognosis of patients with EOC.
Keywords: ovarian carcinoma prognostic factors surgery chemotherapy survival
Yuya Dou, Xiaodan Zhang, Yang Li, Fenfen Wang, Xing Xie, Xinyu Wang
Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 223-228 doi: 10.1007/s11684-017-0517-8
The objective of this study is to guide a triage for the management of cervical high-grade squamous intraepithelial lesion (HSIL) patients with positive margin by conization. Clinico-pathological data of HSIL patients with positive margin by conization were retrospectively collected from January 2009 to December 2014. All patients underwent secondary conization or hysterectomy within 6 months. The rate of residual lesion was calculated, and the factors associated with residual lesion were analyzed by univariate and multivariate analyses. Among a total of 119 patients, 56 (47.06%) patients presented residual HSIL in their subsequent surgical specimens, including 4 cases of invasive cervical carcinoma (3 stage IA1 and 1 stage IA2 patients). Univariate analysis showed that patient age>35 years (P=0.005), menopausal period>5 years (P=0.0035), and multiple-quadrant involvement (P=0.001) were significantly correlated with residual disease; however, multivariate analysis revealed that multiple-quadrant involvement (P=0.001; OR, 3.701; 95%CI, 1.496–9.154) was an independent risk factor for residual disease. Nearly half of HSIL patients with positive margin by conization were disease-free in subsequent surgical specimens, and those with multiple positive margins may consider re-conization or re-assessment.
Keywords: cervical high-grade squamous intraepithelial lesion conization positive surgical margin hysterectomy
Frontiers of Medicine doi: 10.1007/s11684-023-0993-y
Keywords: uveal melanoma liver-directed therapy immune checkpoint blockade SIRT anti-PD-1 anti-CTLA-4
Frontiers of Medicine 2022, Volume 16, Issue 4, Pages 610-617 doi: 10.1007/s11684-021-0827-8
Keywords: bevacizumab elderly patient advanced non-small-cell lung cancer overall survival toxicity
Conservation and adaptive reuse of industrial heritage in Shanghai
ZHANG Song
Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 4, Pages 481-490 doi: 10.1007/s11709-007-0065-4
Keywords: evolution industrial international industrial retrospective Shanghai
Chun Chen,Zhihong Cheng,Ping Jiang,Mei Sun,Qi Zhang,Jun Lv
Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 473-480 doi: 10.1007/s11684-016-0479-
Aiming to control rising medical expenditures and help improve China’s healthcare systems, this study examined whether a cap-based medical insurance scheme with shared financial interest between the insurance and healthcare providers is effective in containing hospitals’ C-section medical expenditures. We used 6547 caesarean delivery case records from a teaching tertiary-level general public hospital located in Wuxi, China (2004–2013), and used the Chow test to investigate the possibility of significant variation in mean medical expenditures for caesarean deliveries pre- and post-reform. We also used paired sample t-tests and linear regression models to compare the mean medical expenditures between insured and uninsured women undergoing caesarean delivery during the post-reform period. After the scheme’s implementation, medical expenditures for caesarean deliveries declined and the medical expenditures of women covered by the scheme were significantly lower than those of uninsured patients. These findings indicated the scheme’s effectiveness in minimizing caesarean delivery expenditures. The cap-based medical insurance scheme with shared financial interest between insurance and healthcare providers would likely steer healthcare providers’ behaviors in a more cost-effective direction.
Keywords: maternity insurance scheme financial incentive caesarean delivery medical expenditure China
Guohua Chen, Wen Su, Jiayao Yang, Dan Luo, Ping Xia, Wen Jia, Xiuyang Li, Chuan Wang, Suping Lang, Qingbin Meng, Ying Zhang, Yuhe Ke, An Fan, Shuo Yang, Yujiao Zheng, Xuepeng Fan, Jie Qiao, Fengmei Lian, Li Wei, Xiaolin Tong
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 752-759 doi: 10.1007/s11684-020-0813-6
Keywords: COVID-19 CHM mortality a retrospective cohort study
Clinical laboratory features of Meigs’ syndrome: a retrospective study from 2009 to 2018
Wenwen Shang, Lei Wu, Rui Xu, Xian Chen, Shasha Yao, Peijun Huang, Fang Wang
Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 116-124 doi: 10.1007/s11684-019-0732-6
Keywords: Meigs’ syndrome ovarian thecoma-fibroma NLR (neutrophil to lymphocyte ratio) CD4+ T cells glucose metabolism
Retrospective study of the efficacy and complication of thoracoabdominal incision for nephrectomy: a
Minggen YANG, Xiaokun ZHAO
Frontiers of Medicine 2009, Volume 3, Issue 2, Pages 191-196 doi: 10.1007/s11684-009-0026-5
Keywords: surgery renal tumors nephrectomy
An investigation on modification mechanism of CH
Qiang XIN, Shanghong HUANG
Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 3, Pages 293-300 doi: 10.1007/s11709-017-0403-0
Keywords: low temperature coal tar pitch modification road performance
Multi-scale investigation of active failure for various modes of wall movement
Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 4, Pages 961-979 doi: 10.1007/s11709-021-0738-4
Keywords: discrete-element modelling granular materials retaining walls particle shape arching
Title Author Date Type Operation
Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19
Xiaofang Cai, Hanlan Jiang, Simin Zhang, Shengying Xia, Wenhui Du, Yaoling Ma, Tao Yu, Wenbin Li
Journal Article
Aortic aneurysm and chronic disseminated intravascular coagulation: a retrospective study of 235 patients
Yun Zhang,Chen Li,Min Shen,Bao Liu,Xuejun Zeng,Ti Shen
Journal Article
Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective
Journal Article
infections among diarrheal outpatients in Shanghai: a retrospective case study
Yanyan Jiang, Zhongying Yuan, Guoqing Zang, Dan Li, Ying Wang, Yi Zhang, Hua Liu, Jianping Cao, Yujuan Shen
Journal Article
prognostic factors of patients with epithelial ovarian cancer subjected to first-line treatment: a retrospective
Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie
Journal Article
cervical high-grade squamous intraepithelial lesion patients with positive margin by conization: a retrospective
Yuya Dou, Xiaodan Zhang, Yang Li, Fenfen Wang, Xing Xie, Xinyu Wang
Journal Article
survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a retrospective
Journal Article
pemetrexed and platinum for elderly patients with advanced non-squamous non-small-cell lung cancer: a retrospective
Journal Article
the new maternity insurance scheme on medical expenditures for caesarean delivery in Wuxi, China: a retrospective
Chun Chen,Zhihong Cheng,Ping Jiang,Mei Sun,Qi Zhang,Jun Lv
Journal Article
herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective
Guohua Chen, Wen Su, Jiayao Yang, Dan Luo, Ping Xia, Wen Jia, Xiuyang Li, Chuan Wang, Suping Lang, Qingbin Meng, Ying Zhang, Yuhe Ke, An Fan, Shuo Yang, Yujiao Zheng, Xuepeng Fan, Jie Qiao, Fengmei Lian, Li Wei, Xiaolin Tong
Journal Article
Clinical laboratory features of Meigs’ syndrome: a retrospective study from 2009 to 2018
Wenwen Shang, Lei Wu, Rui Xu, Xian Chen, Shasha Yao, Peijun Huang, Fang Wang
Journal Article
Retrospective study of the efficacy and complication of thoracoabdominal incision for nephrectomy: a
Minggen YANG, Xiaokun ZHAO
Journal Article