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Unraveling the complex roles of macrophages in obese adipose tissue: an overview

Frontiers of Medicine 2024, Volume 18, Issue 2,   Pages 205-236 doi: 10.1007/s11684-023-1033-7

Abstract: Unraveling the complex roles of macrophages in obese adipose tissue: an overview

Keywords： roles macrophages adipose    

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The Dual Regulatory Roles of Macrophages in Acute Allogeneic Organ Graft Rejection Review

Liang Tan, Yinan Guo, Chang Feng, Yangxiao Hou, Xubiao Xie, Yong Zhao

Engineering 2022, Volume 10, Issue 3,   Pages 21-29 doi: 10.1016/j.eng.2021.10.015

Abstract: Macrophages are functionally heterogeneous and plastic.Although researchers recognize the potential roles macrophages play in allograft injury, they pay insufficientattention to the diverse roles of macrophages in allograft rejection.We herein briefly summarize the distinctive roles of macrophages in acute transplant immune responseand the effect of immunosuppressive drugs on macrophages.

Keywords： Macrophages     Transplantation     Tolerance     Rejection     Regulatory macrophage    

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Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia

Meng Dong, Jun Lin, Wonchung Lim, Wanzhu Jin, Hyuek Jong Lee

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 130-138 doi: 10.1007/s11684-017-0555-2

Abstract:

Brown adipose tissue (BAT) plays a fundamental role in maintaining body temperature by producing heatIn addition, beige adipocytes, brown adipocytes in white adipose tissue (WAT), have also been shown to

Keywords： brown adipose tissue     beige adipocyte     anti-obesity     anti-diabetes     cancer cachexia     aging    

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Investigation of the roles of lignin in biomass-based hydrogel for efficient desalination

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 7,   Pages 954-965 doi: 10.1007/s11705-023-2311-2

Abstract: The shortage of freshwater has become a global challenge, and solar-driven interfacial evaporation for desalination is a promising way to alleviate the crisis. To develop highly efficient and environmentally friendly photothermal evaporator, the hydroxyethyl cellulose (HEC)/alkaline lignin (AL)/graphene oxide (GO) hydrogels (CLGs) with remarkable evaporative performance were successfully fabricated by a facile sol–gel method using biomass residues. The influence of AL content on the physicochemical properties of the evaporator was investigated. The increasing content of AL improves the mechanical properties, saturated water content and crosslink density of the hydrogels. The designed materials exhibit outstanding thermal insulation capacity (the thermal conductivity of less than 0.05 W·m–1·K–1) and high light absorption capacity of more than 97%. The solar evaporation efficiency and water evaporation rate of the HEC/64 wt % of AL/GO hydrogels (CLG4) achieve 92.1% and 2.55 kg·m–2·h–1 under 1 sun, respectively. The salt resistance test results reveal that the evaporation rate of the CLG4 can still reach 2.44 kg·m–2·h–1 in 3.5 wt % NaCl solution. The solar evaporation rate of the CLG4 can maintain in the range of 2.45–2.59 kg·m–2·h–1 in five cycles. This low-cost lignin-based photothermal evaporator offers a sustainable strategy for desalination.

Keywords： lignin     photothermal     cellulose     desalination     hydrogel    

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Paeoniflorin prevents hepatic fibrosis of by inhibiting TGF-β1 production from macrophages in mice

CHU Deyong, LI Conglei, SHEN Jilong, WU Qiang

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 154-165 doi: 10.1007/s11684-008-0029-7

Abstract: 1 from mouse peritoneal macrophages (PM?s) was investigated by RT-PCR, Western blotting and ELISA.

Keywords： cercariae     collagen     hyaluronic     OPMCM     soluble    

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Emerging roles of liquid metals in carbon neutrality

Frontiers in Energy 2022, Volume 16, Issue 3,   Pages 393-396 doi: 10.1007/s11708-022-0829-5

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Regulations of mA and other RNA modifications and their roles in cancer

Frontiers of Medicine doi: 10.1007/s11684-024-1064-8

Abstract: RNA modification is an essential component of the epitranscriptome, regulating RNA metabolism and cellular functions. Several types of RNA modications have been identified to date; they include N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C), N7-methylguanosine (m7G), N6,2′-O-dimethyladenosine (m6Am), N4-acetylcytidine (ac4C), etc. RNA modifications, mediated by regulators including writers, erasers, and readers, are associated with carcinogenesis, tumor microenvironment, metabolic reprogramming, immunosuppression, immunotherapy, chemotherapy, etc. A novel perspective indicates that regulatory subunits and post-translational modifications (PTMs) are involved in the regulation of writer, eraser, and reader functions in mediating RNA modifications, tumorigenesis, and anticancer therapy. In this review, we summarize the advances made in the knowledge of different RNA modifications (especially m6A) and focus on RNA modification regulators with functions modulated by a series of factors in cancer, including regulatory subunits (proteins, noncoding RNA or peptides encoded by long noncoding RNA) and PTMs (acetylation, SUMOylation, lactylation, phosphorylation, etc.). We also delineate the relationship between RNA modification regulator functions and carcinogenesis or cancer progression. Additionally, inhibitors that target RNA modification regulators for anticancer therapy and their synergistic effect combined with immunotherapy or chemotherapy are discussed.

Keywords： RNA modification     writers     erasers     readers     regulatory subunits     PTMs     cancer    

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Protective roles of heat stress on the neurons in hippocampal CA1 region of mice

WANG Chunxu, WANG Hanxing

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 418-422 doi: 10.1007/s11684-007-0082-7

Abstract: The effects of heat stress on the neurons in hippocampal CA1 region of brain ischemia/reperfusion were explored. The mice were pretreated with heat stress followed by ischemia/reperfusion by clipping bilateral cervical commo n arteries for 7 min. Mice were divided randomly into four groups as follows: (1) normal control group; (2) heat stress pretreated subsequent to ischemia/reperfusion group (HS/IR); (3) ischemia/reperfusion group (IR); and (4) heat stress group (HS). Animals in the last three groups were subdivided into three subgroups: 1 d, 4 d, 14 d respectively. The Morris water maze was used to test the ability of learning and memorizing, Nissl staining was used to count the average number of survived neurons in hippocampal CA1 region, and immunohistochemistry combined with image analysis system to detect the changes of Microtubule associated protein 2 (MAP-2) expression. The results showed that mice in IR group exhibited increased escape latency when compared with that of normal, HS and HS/IR groups (<0.01), and the mice in IR group adopted an inefficient search strategy, major in circling and restricted searching manners. Nissl staining results showed a significant reduction in the number of pyramidal neurons in hippocampal CA1 regions in HS/IR and IR groups, with a decrease in IR group (<0.01). Compared with normal group, the expression of MAP-2 in hippocampal CA1 region obviously decreased in IR group (<0.05). The present results indicate that heat stress pretreatment can improve the spatial learning and memorizing function through protection to hippocampal neurons.
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Emerging roles of podoplanin in vascular development and homeostasis

Yanfang Pan,Lijun Xia

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 421-430 doi: 10.1007/s11684-015-0424-9

Abstract: This review provides a comprehensive overview of the roles of PDPN in vascular development and lymphoid

Keywords： podoplanin     CLEC-2     Prox1     O-glycosylation     lymphatic vascular development and maintenance     lymphoid organ homeostasis    

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MicroRNAs and their roles in osteoclast differentiation

Zhuying Xia, Chao Chen, Peng Chen, Hui Xie, Xianghang Luo

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 414-419 doi: 10.1007/s11684-011-0168-0

Abstract: Osteoclasts, which are derived from monocyte-macrophage precursors, are exclusive bone resorption cells. Limited evidence indicates that a class of small non-coding single-stranded RNAs known as “microRNAs” (miRNAs) is also involved in bone resorption. Although various miRNAs regulate cell proliferation and differentiation, few miRNAs have been reported to play a key role in the regulation of osteoclast differentiation. In this short review, the biology and functional mechanisms of miRNAs in osteoclastogenesis are summarized. The profiling, function, and target prediction of miRNAs are discussed as well.

Keywords： miRNA     osteoclast differentiation     antagomirs    

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The greater roles of indigenous microorganisms in removing nitrobenzene from sediment compared with the

Xiangqun Chi, Yingying Zhang, Daosheng Wang, Feihua Wang, Wei Liang

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 1, doi: 10.1007/s11783-018-1016-0

Abstract: days in native sediments, raising the possibility that indigenous microorganisms may play important roles

Keywords： Community structure     Indigenous microorganisms     Nitrobenzene     Plant-microbe associated remediation     Sediment    

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Digitalization for supply chain resilience and robustness: The roles of collaboration and formal contracts

Frontiers of Engineering Management 2023, Volume 10, Issue 1,   Pages 5-19 doi: 10.1007/s42524-022-0229-x

Abstract: Findings reveal the differential roles of digitalization as a technical factor and supply chain collaboration

Keywords： digitalization     supply chain     resilience     robustness     collaboration     formal contract    

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Elevated methylmercury production in mercury-contaminated soil and its bioaccumulation in rice: key roles

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 12, doi: 10.1007/s11783-023-1745-6

Abstract:

● AOM input elevates water-soluble cysteine and labile DOM fractions in soil.

Keywords： Mercury     Methylmercury     Algae     Organic matter     Rice (Oryza sativa L.)    

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Cadmium removal mechanistic comparison of three Fe-based nanomaterials: Water-chemistry and roles of

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 12, doi: 10.1007/s11783-022-1586-8

Abstract:

● nZVI, S-nZVI, and nFeS were systematically compared for Cd(II) removal.

Keywords： Nano zero valent iron     Sulfided zero valent iron     FeS     Cd(II) immobilization     Fe dissolution    

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Balancing resilience and efficiency in supply chains: Roles of disruptive technologies under Industry

Frontiers of Engineering Management 2023, Volume 10, Issue 1,   Pages 171-176 doi: 10.1007/s42524-022-0247-8

Abstract: In the Industry 4.0 era, disruptive technologies such as big data analytics, blockchain, Internet-of-Things, and additive manufacturing have become major forces driving supply chain transformation. Under such circumstances, particular attention should be attached to balancing resilience and efficiency of the supply chain, especially in the presence of more turbulence. In this study, we first summarize the conflicts between supply chain efficiency and supply chain resilience regarding practices and objectives. Then, we discuss the positive effects of disruptive technologies in improving resilience and efficiency. Afterwards, we propose a research agenda that covers both the influence mechanism and trade-off mechanism of these technologies in terms of resilience and efficiency.

Keywords： disruptive technologies     supply chain     resilience     efficiency     paradox     balance    

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Title Author Date Type Operation

Unraveling the complex roles of macrophages in obese adipose tissue: an overview

Journal Article

The Dual Regulatory Roles of Macrophages in Acute Allogeneic Organ Graft Rejection

Liang Tan, Yinan Guo, Chang Feng, Yangxiao Hou, Xubiao Xie, Yong Zhao

Journal Article

Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia

Meng Dong, Jun Lin, Wonchung Lim, Wanzhu Jin, Hyuek Jong Lee

Journal Article

Investigation of the roles of lignin in biomass-based hydrogel for efficient desalination

Journal Article

Paeoniflorin prevents hepatic fibrosis of by inhibiting TGF-β1 production from macrophages in mice

CHU Deyong, LI Conglei, SHEN Jilong, WU Qiang

Journal Article

Emerging roles of liquid metals in carbon neutrality

Journal Article

Regulations of mA and other RNA modifications and their roles in cancer

Journal Article

Protective roles of heat stress on the neurons in hippocampal CA1 region of mice

WANG Chunxu, WANG Hanxing

Journal Article

Emerging roles of podoplanin in vascular development and homeostasis

Yanfang Pan,Lijun Xia

Journal Article

MicroRNAs and their roles in osteoclast differentiation

Zhuying Xia, Chao Chen, Peng Chen, Hui Xie, Xianghang Luo

Journal Article

The greater roles of indigenous microorganisms in removing nitrobenzene from sediment compared with the

Xiangqun Chi, Yingying Zhang, Daosheng Wang, Feihua Wang, Wei Liang

Journal Article

Digitalization for supply chain resilience and robustness: The roles of collaboration and formal contracts

Journal Article

Elevated methylmercury production in mercury-contaminated soil and its bioaccumulation in rice: key roles

Journal Article

Cadmium removal mechanistic comparison of three Fe-based nanomaterials: Water-chemistry and roles of

Journal Article

Balancing resilience and efficiency in supply chains: Roles of disruptive technologies under Industry

Journal Article