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acetaminophen 1

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Interfacial induction and regulation for microscale crystallization process: a critical review

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 6,   Pages 838-853 doi: 10.1007/s11705-021-2129-8

Abstract: Microscale crystallization is at the frontier of chemical engineering, material science, and biochemical research and is affected by many factors. The precise regulation and control of microscale crystal processes is still a major challenge. In the heterogeneous induced nucleation process, the chemical and micro/nanostructural characteristics of the interface play a dominant role. Ideal crystal products can be obtained by modifying the interface characteristics, which has been proven to be a promising strategy. This review illustrates the application of interface properties, including chemical characteristics (hydrophobicity and functional groups) and the morphology of micro/nanostructures (rough structure and cavities, pore shape and pore size, surface porosity, channels), in various microscale crystallization controls and process intensification. Finally, possible future research and development directions are outlined to emphasize the importance of interfacial crystallization control and regulation for crystal engineering.

Keywords： interfacial crystallization     heterogeneous nucleation     supersaturation     micro/nanostructure     process    

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Effects of a structurally related substance on the crystallization of paracetamol

Ali SALEEMI, I.I. ONYEMELUKWE, Zoltan NAGY

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 79-87 doi: 10.1007/s11705-013-1308-7

Abstract: A supersaturation control (SSC) approach was implemented for the PCM-IPA system with and without metacetamol

Keywords： acetaminophen     metacetamol     crystallization     metastable zone width     induction time     supersaturation control    

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Oral product input to the GI tract: GIS an oral product performance technology

Gordon L. Amidon, Yasuhiro Tsume

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 516-520 doi: 10.1007/s11705-017-1658-7

Abstract: dissolution system allows the monitoring of the drug dissolution phenomena and the observation of the supersaturation

Keywords： GIS     in vivo predictive dissolution     ketoconazole     BCS subclassification     supersaturation    

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Purification and crystallization of xylitol from fermentation broth of corncob hydrolysates

Jinchao WEI, Qipeng YUAN, Tianxin WANG, Le WANG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 57-64 doi: 10.1007/s11705-009-0295-1

Abstract: Then the solution was vacuum-concentrated up to supersaturation (750g/L xylitol).

Keywords： ion-exchange     activated     supersaturation     tetrahedral     substitute    

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Title Author Date Type Operation

Interfacial induction and regulation for microscale crystallization process: a critical review

Journal Article

Effects of a structurally related substance on the crystallization of paracetamol

Ali SALEEMI, I.I. ONYEMELUKWE, Zoltan NAGY

Journal Article

Oral product input to the GI tract: GIS an oral product performance technology

Gordon L. Amidon, Yasuhiro Tsume

Journal Article

Purification and crystallization of xylitol from fermentation broth of corncob hydrolysates

Jinchao WEI, Qipeng YUAN, Tianxin WANG, Le WANG,

Journal Article