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genome-wide association study 2

haplotype 2

lung cancer 2

obesity 2

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6-trichlorophenol 1

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DQB1 1

Florfenicol 1

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Interplay between diet and genetic susceptibility in obesity and related traits

Tiange Wang, Min Xu, Yufang Bi, Guang Ning

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 601-607 doi: 10.1007/s11684-018-0648-6

Abstract: Longitudinal studies and randomized intervention trials have shown that genetic susceptibility to obesity

Keywords： diet     genetic susceptibility     obesity     interaction    

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DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese

Wei Wang,Ming Li,Li Wang,Xueqing Yu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 507-516 doi: 10.1007/s11684-016-0475-6

Abstract: shown the ethnic-specific association between certain human leukocyte antigen (HLA) alleles and IgAN susceptibilityThis study was designed to explore the relationship between HLA-DQB1 alleles and disease susceptibilityOur study indicated that HLA-DQB1*060101 alleles may be a potential predictor of high-risk IgAN susceptibility

Keywords： DQB1     human leukocyte antigen (HLA)     IgA nephropathy     haplotype     association study    

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Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness

Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun

Frontiers of Engineering Management 2016, Volume 3, Issue 1,   Pages 30-38 doi: 10.15302/J-FEM-2016008

Abstract: It is suggested that the accident-prone drivers may have the idiosyncrasy of susceptibility.

Keywords： accident proneness     genome-wide association study (GWAS)     dopamine (DA)     ACTH     susceptibility gene     traffic    

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Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 146-161 doi: 10.1007/s11684-014-0373-8

Abstract: As of this writing, more than 73 obesity susceptibility loci have been identified in ethnic groups through

Keywords： obesity     genetics     genome-wide association studies     body mass index     fat mass- and obesity-associated gene    

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Is tailored therapy based on antibiotic susceptibility effective?

Jie Pan, Zhengchao Shi, Dingsai Lin, Ningmin Yang, Fei Meng, Lang Lin, Zhencheng Jin, Qingjie Zhou, Jiansheng Wu, Jianzhong Zhang, Youming Li

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 43-50 doi: 10.1007/s11684-019-0706-8

Abstract: In this study, we assessed whether tailored therapy based on antibiotic susceptibility testing is moreFor the TATT and TABQT groups, antibiotic selection proceeded via susceptibility testing using an agar-dilutionSusceptibility testing was conducted using an agar-dilution test.

Keywords： tailored bismuth-containing quadruple therapy     traditional bismuth-containing quadruple therapy     antibiotic susceptibility    

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Susceptibility of male and female Japanese medaka (

Nannan LIU, Mei MA, Yiping XU, Jinmiao ZHA, Kaifeng RAO, Zijian WANG

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 1,   Pages 77-84 doi: 10.1007/s11783-012-0466-z

Abstract: 2,4,6-trichlorophenol (2,4,6-TCP) is a widespread probable human carcinogen and has been proven to have genotoxicity in assays. However, little genotoxicity information and no micronuclei induction data for 2,4,6-TCP is available from tests, especially for sex-specific differences. Following a preliminary test, a piscine peripheral erythrocyte micronucleus assay was conducted on medaka ( ) after a 28-day exposure to 2,4,6-TCP. In the present study, the mean micronuclei (MNC) frequencies of all of the groups increased in a dose-dependent manner, which indicated the potential genotoxicity of 2,4,6-TCP. Moreover, males were found to be more susceptible compared with females after a 28-day exposure to 2,4,6-TCP in all of the dosed groups above 10 μg·L . This is the first report on the potential of micronuclei induction and a sex-susceptible effect in the peripheral erythrocytes of mature fish after 2,4,6-TCP exposure.

Keywords： 2     4     6-trichlorophenol     genotoxicity     Japanese medaka     piscine micronucleus test in peripheral erythrocytes     gender difference    

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Functional XPF polymorphisms associated with lung cancer susceptibility in a Chinese population

Dian-Ke YU PhD, Chen WU MD, Wen TAN MD, Dong-Xin LIN MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 82-89 doi: 10.1007/s11684-010-0014-9

Abstract: Variation of individuals’ DNA repair capacity has been linked to cancer susceptibility.These findings suggest that functional polymorphisms influencing DNA repair capacity may confer susceptibility

Keywords： XPF     polymorphism     lung cancer    

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Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene

SUN Pin, ZHANG Zhongbin, WU Fen, WAN Junxiang, JIN Xibeng, XIA Zhaolin

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 320-326 doi: 10.1007/s11684-007-0062-y

Abstract: The aim of this study was to explore the association of the genetic polymorphism of and with the susceptibilitypopulation and further research is needed for the association between the genetic polymorphism in and the susceptibility

Keywords： case-control     rs2854451     regression analysis     haplotype     further research    

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Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical isolates from a hospital in Shanghai, China

Ying Ma,Nanxue Zhang,Shi Wu,Haihui Huang,Yanpei Cao

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 517-521 doi: 10.1007/s11684-016-0480-9

Abstract: The susceptibility to triple antibiotic ointment (neomycin/bacitracin/polymyxin B) and bacitracin wasThe susceptibility to fusidic acid was 92.7%.

Keywords： antimicrobial susceptibility/resistance     Propionibacterium acnes     topical antibiotics     in vitro study    

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U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control study in Chinese population

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 478-486 doi: 10.1007/s11684-015-0420-0

Abstract: No significant associations were observed between the eight reported TL-SNPs and ESCC susceptibility.

Keywords： esophageal squamous cell carcinoma     telomere length     genetic variants     susceptibility     genome-wide association    

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Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control study in Han Chinese people

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 90-95 doi: 10.1007/s11684-010-0021-x

Abstract: This study aimed to identify functional single nucleotide polymorphisms in the cyclooxygenase-2 gene promoter and evaluate their effects on the risk of primary hepatocellular carcinoma (HCC) with hepatitis B virus (HBV) infection. We conducted a population-based, case-control study enrolling 630 Han Chinese people in Hubei province. Subjects included primary HCC patients with HBV infection (=210), chronic hepatitis B cases (=210) and healthy Han Chinese (=210). -1195G/A polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sequencing analysis. We found-1195A allele carriers had a higher risk of HCC with HBV infection (OR, 0.72; 95% CI, 0.548–0.946). The-1195A allele might be used as a marker in screening individuals at high risk of HCC with HBV infection.

Keywords： cyclooxygenase-2 gene     single nucleotide polymorphisms     susceptibility     primary hepatocellular carcinoma    

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Presence and Antimicrobial Susceptibility of RE-cmeABC-Positive Campylobacter Isolated Article

Dejun Liu, Weiwen Liu, Xing Li, Hong Yao, Zhangqi Shen, Yang Wang, Jianzhong Shen

Engineering 2020, Volume 6, Issue 1,   Pages 34-39 doi: 10.1016/j.eng.2019.10.013

Abstract: In this study, we analyzed the presence and antimicrobial susceptibility of RE-cmeABC-positive

Keywords： RE-cmeABC     Campylobacter     Ciprofloxacin     Florfenicol    

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Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between

Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Guangfu Jin, David C. Christiani, Zhibin Hu, Christopher I. Amos, Hongxia Ma, Hongbing Shen

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 275-291 doi: 10.1007/s11684-020-0779-4

Abstract: we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibilityOur results illustrate the molecular basis of both well-studied and new susceptibility loci of NSCLC,

Keywords： lung cancer     genome-wide association study     function annotation     immune     homologous recombination repair deficiency     genetic heterogeneity    

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Title Author Date Type Operation

Interplay between diet and genetic susceptibility in obesity and related traits

Tiange Wang, Min Xu, Yufang Bi, Guang Ning

Journal Article

DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese

Wei Wang,Ming Li,Li Wang,Xueqing Yu

Journal Article

Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness

Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun

Journal Article

Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Journal Article

Is tailored therapy based on antibiotic susceptibility effective?

Jie Pan, Zhengchao Shi, Dingsai Lin, Ningmin Yang, Fei Meng, Lang Lin, Zhencheng Jin, Qingjie Zhou, Jiansheng Wu, Jianzhong Zhang, Youming Li

Journal Article

Susceptibility of male and female Japanese medaka (

Nannan LIU, Mei MA, Yiping XU, Jinmiao ZHA, Kaifeng RAO, Zijian WANG

Journal Article

Functional XPF polymorphisms associated with lung cancer susceptibility in a Chinese population

Dian-Ke YU PhD, Chen WU MD, Wen TAN MD, Dong-Xin LIN MD,

Journal Article

Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene

SUN Pin, ZHANG Zhongbin, WU Fen, WAN Junxiang, JIN Xibeng, XIA Zhaolin

Journal Article

Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical isolates from a hospital in Shanghai, China

Ying Ma,Nanxue Zhang,Shi Wu,Haihui Huang,Yanpei Cao

Journal Article

U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control study in Chinese population

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Journal Article

Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control study in Han Chinese people

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

Journal Article

Presence and Antimicrobial Susceptibility of RE-cmeABC-Positive Campylobacter Isolated

Dejun Liu, Weiwen Liu, Xing Li, Hong Yao, Zhangqi Shen, Yang Wang, Jianzhong Shen

Journal Article

Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between

Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Guangfu Jin, David C. Christiani, Zhibin Hu, Christopher I. Amos, Hongxia Ma, Hongbing Shen

Journal Article