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telomere 2

antineoplasic drugs 1

cancer 1

conventional chemotherapies 1

esophageal squamous cell carcinoma 1

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Association between telomere length and survival in cancer patients: a meta-analysis and review of literature

Xinsen Xu,Kai Qu,Qing Pang,Zhixin Wang,Yanyan Zhou,Chang Liu

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 191-203 doi: 10.1007/s11684-016-0450-2

Abstract:

The relationship between telomere length and cancer survival has been widely studied.A total of 29 studies evaluated telomere length in the peripheral blood; 22 studies evaluated telomereFirst, in the peripheral blood studies, for solid tumor patients with shortened telomere length, theIn the studies that calculate the telomere length ratios of tumor tissue to adjacent normal mucosa, forpatients with lower telomere length ratios, the combined HRs were 0.66 (95%CI, 0.53–0.83) and

Keywords： telomere     survival     cancer     meta-analysis    

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U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 478-486 doi: 10.1007/s11684-015-0420-0

Abstract: Epidemiological studies have suggested that inter-individual differences of telomere length could affectSeveral telomere length-related single nucleotide polymorphisms (TL-SNPs) in Caucasians have been reportedHowever, the effects of telomere length and TL-SNPs on ESCC development are unclear.conducted a case-control study (1045 ESCC cases and 1433 controls) to evaluate the associations between telomereAs a result, ESCC cases showed overall shorter relative telomere length (RTL) (median: 1.34) than controls

Keywords： esophageal squamous cell carcinoma     telomere length     genetic variants     susceptibility     genome-wide association    

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Telomeric impact of conventional chemotherapy

Yiming Lu, Waiian Leong, Olivier Guérin, Eric Gilson, Jing Ye

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 411-417 doi: 10.1007/s11684-013-0293-z

Abstract: A wealth of published evidence showed that telomere stability can be more affected than the bulk of theIn agreement with this view, accelerated shortening of telomere length has been described in blood lineageHowever, almost nothing is known on the consequences of this shortening in terms of telomere stabilitycancer cells are preferential genomic targets of chemotherapies altering chromosome maintenance; (2) telomereparameters can be a surrogate marker of chemotherapy sensitivity and toxicity; (3) the use of anti-telomere

Keywords： telomere     antineoplasic drugs     conventional chemotherapies    

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Title Author Date Type Operation

Association between telomere length and survival in cancer patients: a meta-analysis and review of literature

Xinsen Xu,Kai Qu,Qing Pang,Zhixin Wang,Yanyan Zhou,Chang Liu

Journal Article

U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Journal Article

Telomeric impact of conventional chemotherapy

Yiming Lu, Waiian Leong, Olivier Guérin, Eric Gilson, Jing Ye

Journal Article