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reinforces antidepressant effects of ketamine with increased levels of brain-derived neurotrophic factor and tropomyosin-relatedkinase B in rat hippocampus

Chun Yang, Xiaomin Li, Nan Wang, Shixia Xu, Jianjun Yang, Zhiqiang Zhou

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 411-415 doi: 10.1007/s11684-012-0226-2

Abstract: Brain-derived neurotrophic factor (BDNF) is an important biomarker for mood disorders and tropomyosin-relatedkinase B (TrkB) is a high affinity catalytic receptor for BDNF.

Keywords： tramadol     ketamine     antidepressant     brain-derived neurotrophic factor     tropomyosin-related kinase B    

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Protective effect of tanshinone II A on signal transduction system protein kinase B in rats with myocardial

Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 431-436 doi: 10.1007/s11684-009-0088-4

Abstract: The effects of tanshinone II A on cell signal transduction system protein kinase B in rats with myocardialdiameter (MFD) was examined by Hematoxylin-Eosin (HE) staining, and the contents of phosphorylated protein kinaseB (p-Akt) and p-Gsk3β in myocardium were assayed by Western blot.

Keywords： tanshinone II A     myocardial hypertrophy     rat     protein kinase B     abdominal aorta coarctation    

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Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 200-206 doi: 10.1007/s11684-007-0038-y

Abstract: Elevated plasma levels of free fatty acids (FFAs) may contribute to insulin resistance (IR) that is characteristic of type 2 diabetes mellitus. In this study, we investigated the effects of two fatty acids, palmitate (PA) and arach

Keywords： palmitate     characteristic     study     plasma     resistance    

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Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 883-895 doi: 10.1007/s11684-022-0919-0

Abstract: We further examined the expression of the autophagy-related genes Beclin1 and LC3B in 82 patients throughimmunohistochemistry and found that Beclin1 and LC3B were highly related to unfavorable prognosis ofKnockdown of Beclin1 and LC3B reduced invasion, metastasis, and proliferation in metastatic osteosarcomaMoreover, we demonstrated that autophagy-related genes were activated by SEs and that the inhibition

Keywords： osteosarcoma     autophagy     metastasis     drug resistance     Beclin1     LC3B    

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Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 134-138 doi: 10.1007/s11684-015-0396-9

Abstract: In this review, we discuss the main known mechanisms of resistance to receptor tyrosine kinase inhibitors

Keywords： targeted therapy     drug resistance     receptor tyrosine kinases     cancer    

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Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 481-489 doi: 10.1007/s11684-016-0494-3

Abstract:

The tumor suppressor gene liver kinase B1 (LKB1), also called STK11, encodes a serine/threonine kinase

Keywords： LKB1     stereociliary bundles     kinocilium     planar cell polarity     hearing     mice    

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Bismuth oxide-related photocatalysts in green nanotechnology: A critical analysis

Vocciante, B. Fabiano

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 4,   Pages 878-892 doi: 10.1007/s11705-018-1744-5

Abstract: A survey addressing the uses of bismuth oxide in photocatalysis is presented. The richness of literature on such a specific topic proves the growing importance of this compound as a valid tool in pollution abatement and environmental decontamination. Many research groups have focused their activity on how to improve the photocatalytic properties of this semiconductor and several solutions have been adopted in the synthesis method, often based on wet-chemical processes. The impressive development of nanoscience helped in understanding and identifying process variables and operative conditions aiming at optimizing the yield of this promising photocatalytic material in the utilization of solar energy.

Keywords： photocatalysis     visible light     bismuth compounds     nanotechnology     environmental remediation     decontamination     pollution abatement    

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medicine regulating liver regeneration” treatment plan for reducing mortality of patients with hepatitis B-related

Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 495-505 doi: 10.1007/s11684-020-0790-9

Abstract: A total of 457 patients with HBV-related liver failure were retrospectively collected.In addition, there were significant differences in the expression of several cytokines related to liverdecrease jaundice, improve liver function, and significantly reduce the mortality in patients with HBV-relatedThe mechanism may be related to the role of RLR treatment in influencing cytokines related to liver regeneration

Keywords： hepatitis B virus-related liver failure     traditional Chinese medicine     liver regeneration     liver regeneration    

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Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 232-237 doi: 10.1007/s11705-012-1286-1

Abstract: animals were examined respectively for inoculation of inhibitor of p38 MAPK (mitogen activated protein kinase

Keywords： connective tissue     mitogen activated protein kinase (MAPK)     p38     JNK    

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The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 70-76 doi: 10.1007/s11684-011-0119-9

Abstract:

Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family.

Keywords： protein kinase C ?     signal transduction     neurogenic disease    

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Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe

Frontiers of Medicine doi: 10.1007/s11684-024-1063-9

Abstract: Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe

Keywords： study China     world effectiveness safety    

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Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 383-388 doi: 10.1007/s11684-016-0488-1

Abstract:

The tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) are becoming the

Keywords： EGFR     tyrosine kinase inhibitor     AZD9291     EAI045    

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Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 235-238 doi: 10.1007/s11684-008-0044-8

Abstract: The aim of this study is to investigate the effect of tyrosine kinase Src on Tyrosine 307(Y307) phosphorylation

Keywords： hyperphosphorylation     PP2A activity     cellular regulation     siRNA     siRNA transfection    

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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: non-specific activation of effector T cells, ICIs are remarkably associated with a substantial risk of immune-related

Keywords： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

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Projections of heat-related excess mortality in China due to climate change, population and aging

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 11, doi: 10.1007/s11783-023-1732-y

Abstract:

● Four scenarios were used to project heat-related excess mortality

Keywords： Heat-related excess mortality     LMDI     Aging     YLL     VSLY    

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Title Author Date Type Operation

reinforces antidepressant effects of ketamine with increased levels of brain-derived neurotrophic factor and tropomyosin-relatedkinase B in rat hippocampus

Chun Yang, Xiaomin Li, Nan Wang, Shixia Xu, Jianjun Yang, Zhiqiang Zhou

Journal Article

Protective effect of tanshinone II A on signal transduction system protein kinase B in rats with myocardial

Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,

Journal Article

Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Journal Article

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Journal Article

Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Journal Article

Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Journal Article

Bismuth oxide-related photocatalysts in green nanotechnology: A critical analysis

Vocciante, B. Fabiano

Journal Article

medicine regulating liver regeneration” treatment plan for reducing mortality of patients with hepatitis B-related

Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu

Journal Article

Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Journal Article

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Journal Article

Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe

Journal Article

Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu

Journal Article

Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Journal Article

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Journal Article

Projections of heat-related excess mortality in China due to climate change, population and aging

Journal Article