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Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 747-757 doi: 10.1007/s11684-022-0954-x

Abstract: efficacy of inactivated vaccination in neutralization against emerging variants and antigen-specific Bcell response.Similarly, the responses of SARS-CoV-2 RBD-specific B cells and memory B cells were boosted by the secondor two doses), which enhanced neutralization against highly mutated SARS-CoV-2 variants and memory Bcell responses.

Keywords： COVID-19 convalescent     SARS-CoV-2     inactivated vaccination     neutralizing antibody     B cell response    

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CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 783-804 doi: 10.1007/s11684-021-0904-z

Abstract: Chimeric antigen receptor T-cell (CAR T) immunotherapy opens a new path for targeted therapy of hematologicalIn this review, through a representative case study, we summarize the current experience of CAR T-cellthe causative mechanisms of therapy resistance, and new strategies to improve the efficacy of CAR T-cell

Keywords： CAR T cells     hematological malignancies     review    

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Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 815-826 doi: 10.1007/s11684-021-0891-0

Abstract: Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma (BCL)

Keywords： B-cell lymphoma     oral drug     targeted therapy     immunotherapy     COVID-19 pandemic    

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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 503-517 doi: 10.1007/s11684-022-0947-9

Abstract: Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCCALDOB inhibited CtBP2-mediated repression of multiple cell cycle inhibitor, proapoptotic, and epithelial

Keywords： ALDOB     kidney cancer     cell proliferation    

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Depletion of conventional mature B cells and compromised specific antibody response in bovine immunoglobulin

Min ZHANG,Xueqian CHENG,Dan CHU,Jingwen LIANG,Yi SUN,Li MA,Beilei XU,Min ZHENG,Meili WANG,Liming REN,Xiaoxiang HU,Qingyong MENG,Ran ZHANG,Ying GUO,Yunping DAI,Robert AITKEN,Ning LI,Yaofeng ZHAO

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 158-173 doi: 10.15302/J-FASE-2014015

Abstract: The forced expression of bovine IgM resulted in reduced numbers of pro- and pre-B cells but increasedthe number of immature B cells in the transgenic mice.arrested at the T1 transitional B cell stage, leading to a significantly lower number of T2 transitionaland mature B cells in the spleen.Finally, we showed that the transgenic mice were deficient in a specific antibody response to antigen

Keywords： bovine Ig μ heavy-chain     transgenic mice     B cell development     allelic exclusion     immune response     Ig repertoire    

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Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse largeB-cell lymphoma in Chinese patients

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 285-294 doi: 10.1007/s11684-021-0843-8

Abstract: Anti-CD19 chimeric antigen receptor (CAR) T cell therapy has shown impressive efficacy in treating B-cellCAR bearing 4-1BB costimulatory molecule, for the treatment of patients with refractory diffuse large B-cellTen heavily treated patients with refractory DLBCL were given CBM.CD19 CAR-T cell (C-CAR011) treatmentThe overall response rate was 20% and 50% at 4 and 12 weeks after the infusion of C-CAR011, respectively

Keywords： CAR-T cell therapy     refractory diffuse large B-cell lymphoma     cytokine release syndrome     dose-limiting    

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Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal ResidualDisease with No Response to Donor Lymphocytes after Allogeneic Hematopoietic Stem Cell Transplantation Article

Yifei Cheng,Yuhong Chen,Chenhua Yan,Yu Wang,Xiangyu Zhao,Yao Chen,Wei Han,Lanping Xu,Xiaohui Zhang,Kaiyan Liu,Shasha Wang,Lungji Chang,Lei Xiao,Xiaojun Huang

Engineering 2019, Volume 5, Issue 1,   Pages 150-155 doi: 10.1016/j.eng.2018.12.006

Abstract: Leukemia relapse is still the leading cause of treatment failure after allogeneic hematopoietic stem celltransplantation (allo-HSCT) for B cell acute lymphoblastic leukemia (B-ALL).residual disease (MRD) is predictive of forthcoming hematological relapse after hematopoietic stem cellDonor-derived CAR T cell infusions seem to be an effective and safe intervention for patients with MRDin B-ALL after allo-HSCT and for those who were not responsive to DLI.

Keywords： Donor-derived CD19-targeted T cell infusion     Hematopoietic stem cell transplantation     B cell acute lymphoblastic    

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Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: Anti-CD19 chimeric antigen receptor (CAR)-T cell therapy has achieved 40%–50% long-term complete response in relapsed or refractory diffuse large B-cell lymphoma (DLBCLHowever, the underlying mechanism of alterations in the tumor microenvironments resulting in CAR-T cellSingle-cell RNA sequencing results were obtained from core needle biopsy tumor samples collected fromImmunosuppressive tumor microenvironments persisted before CAR-T cell therapy, during both cell expansion

Keywords： anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment    

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Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladdercancer cell in vitro

FAN Xiaodong, HAN Ruifa

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 377-380 doi: 10.1007/s11684-007-0073-8

Abstract: Recombinant IFN--2b-BCG, wild-type BCG (wBCG), wild-type BCG and IFN--2b were coincubated with PBMCs

Keywords： Urology     powerful     2b-BCG     Tianjin institute     wild-type    

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characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cell

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 139-149 doi: 10.1007/s11684-021-0835-8

Abstract: The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients withrelapsed/refractory B-cell precursor acute lymphoblastic leukemia.and A-2019 are potent antitumor agents and capable of recruiting CD3 positive T cells, enhancing T-cellfunction, mediating B-cell depletion, and eventually inhibiting tumor growth in Raji xenograft models

Keywords： B-cell acute lymphoblastic leukemia     bispecific antibody     trispecific antibody     CD19     CD20    

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Optimization and modeling of coagulation-flocculation to remove algae and organic matter from surface water by response

Ziming Zhao, Wenjun Sun, Madhumita B. Ray, Ajay K Ray, Tianyin Huang, Jiabin Chen

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 5, doi: 10.1007/s11783-019-1159-7

Abstract: Optimal coagulation conditions were studied by response surface methodology.absorbance at 254 nm (UV254) was investigated systematically by central composite design (CCD) using responseAnalysis of variance (ANOVA) was performed to test the significance of the response surface models.optimal coagulation conditions with coagulant dosage of 7.57 mg Al/L, pH of 5.42 and initial algal celldensity of 3.83 × 106 cell/mL led to removal of 96.76%, 97.64%, 40.23% and 30.12% in term of cell density

Keywords： Algae     Coagulation-flocculation     Response surface methodology     Artificial neural networks    

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Attuned design of demand response program and M-FACTS for relieving congestion in a restructured market

SHAYEGHI,B. HASHEMI

Frontiers in Energy 2015, Volume 9, Issue 3,   Pages 282-296 doi: 10.1007/s11708-015-0366-6

Abstract: use of multi-converter flexible alternative current transmission systems (M-FACTS) devices and demand response

Keywords： multi-converter flexible alternative current transmission systems (M-FACTS)     demand response     fuzzy decision    

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Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection

Yun Tan, Feng Liu, Xiaoguang Xu, Yun Ling, Weijin Huang, Mingquan Guo, Ziyu Fu, Dongguo Liang, Miao Xu, Hongzhou Lu, Saijuan Chen

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 746-751 doi: 10.1007/s11684-020-0822-5

Abstract: showed significant neutralizing activities in a pseudovirus assay, with no difference in blocking the cell-entryFurthermore, in 10 blood samples from cases at 6−7 months post-infection used for memory T-cell tests

Keywords： SARS-CoV-2     neutralizing antibodies     T-cell response    

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Inhibition of NF-kappa B can enhance Fas-mediated apoptosis in leukemia cell line HL-60

Li WANG, Shi ZHAO, Hong-Xiang WANG, Ping ZOU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 323-328 doi: 10.1007/s11684-010-0026-5

Abstract: This study explored the effects of nuclear factor-kappa B (NF-κB) inhibitor Bay 11-7082 on Fas/FasL systemand Fas-mediated apoptosis in cell line HL-60 cells.

Keywords： nuclear factor-kappa B     Fas/FasL system     HL-60     Bay 11-7082    

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Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 106-111 doi: 10.1007/s11684-010-0004-y

Abstract: Hepatitis B virus X protein (HBx), a 17-kd protein encoded by X gene of hepatitis B virus (HBV), hasinvestigate the extracellular regulated protein kinases (ERKs) pathway of HBx on glomerular mesangial cellHBx upregulates TNF-α expression and induces cell proliferation of GMC line partly through ERK signal

Keywords： hepatitis B virus     X gene     glomerular mesangial cell line     extracellular regulated protein kinases     tumor    

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Title Author Date Type Operation

Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination

Journal Article

CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

Journal Article

Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Journal Article

Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Journal Article

Depletion of conventional mature B cells and compromised specific antibody response in bovine immunoglobulin

Min ZHANG,Xueqian CHENG,Dan CHU,Jingwen LIANG,Yi SUN,Li MA,Beilei XU,Min ZHENG,Meili WANG,Liming REN,Xiaoxiang HU,Qingyong MENG,Ran ZHANG,Ying GUO,Yunping DAI,Robert AITKEN,Ning LI,Yaofeng ZHAO

Journal Article

Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse largeB-cell lymphoma in Chinese patients

Journal Article

Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal ResidualDisease with No Response to Donor Lymphocytes after Allogeneic Hematopoietic Stem Cell Transplantation

Yifei Cheng,Yuhong Chen,Chenhua Yan,Yu Wang,Xiangyu Zhao,Yao Chen,Wei Han,Lanping Xu,Xiaohui Zhang,Kaiyan Liu,Shasha Wang,Lungji Chang,Lei Xiao,Xiaojun Huang

Journal Article

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Journal Article

Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladdercancer cell in vitro

FAN Xiaodong, HAN Ruifa

Journal Article

characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cell

Journal Article

Optimization and modeling of coagulation-flocculation to remove algae and organic matter from surface water by response

Ziming Zhao, Wenjun Sun, Madhumita B. Ray, Ajay K Ray, Tianyin Huang, Jiabin Chen

Journal Article

Attuned design of demand response program and M-FACTS for relieving congestion in a restructured market

SHAYEGHI,B. HASHEMI

Journal Article

Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection

Yun Tan, Feng Liu, Xiaoguang Xu, Yun Ling, Weijin Huang, Mingquan Guo, Ziyu Fu, Dongguo Liang, Miao Xu, Hongzhou Lu, Saijuan Chen

Journal Article

Inhibition of NF-kappa B can enhance Fas-mediated apoptosis in leukemia cell line HL-60

Li WANG, Shi ZHAO, Hong-Xiang WANG, Ping ZOU

Journal Article

Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Journal Article