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Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 19-24 doi: 10.1007/s11684-008-0005-2

Abstract: the effects of RNA interference (RNAi) targeting angiotensin 1a receptor (AT1a) on blood pressure and cardiachypertrophy of rats with renovascular hypertension.targeting AT1a receptor inhibits the development of renovascular hypertension and the accompanying cardiachypertrophy.

Keywords： therapy     Sprague     administration     cardiac hypertrophy     valsartan    

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lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression

Frontiers of Medicine 2024, Volume 18, Issue 3,   Pages 484-498 doi: 10.1007/s11684-023-1036-4

Abstract: The decreased transcriptional activity of ZNF593-AS has also been detected in cardiac hypertrophy.However, the function of ZNF593-AS in cardiac hypertrophy remains unclear.In vivo, ZNF593-AS aggravated pressure overload–induced cardiac hypertrophy in knockout mice.hypertrophy.Therefore, it represents a promising therapeutic target for combating pathological cardiac remodeling

Keywords： lncRNA     ZNF593-AS     cardiac hypertrophy     Mfn2     oxidative phosphorylation.    

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lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1–mitochondrial complex

Frontiers of Medicine doi: 10.1007/s11684-024-1065-7

Abstract: Pathological cardiac hypertrophy, a major contributor to heart failure, is closely linked to mitochondrialThe suppression of Gm20257 by using small interfering RNAs significantly induced cardiomyocyte hypertrophymitigated angiotensin II–induced hypertrophic phenotypes in neonatal mouse ventricular cells or alleviated cardiachypertrophy in a mouse TAC model respectively, thus restoring cardiac function.hypertrophy.

Keywords： lncRNA Gm20257     cardiac hypertrophy     PGC-1α     mitochondrial complex IV     ATP    

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Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 444-456 doi: 10.1007/s11684-015-0421-z

Abstract:

Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events.A cardiomyocyte hypertrophy model induced by angiotensin II (10 nmol·L−1) wasChanges in the cardiac structure and function were assessed through echocardiography and transmissionmitochondria, and the increased surface area in in vivo and in vitro hypertrophy

Keywords： aspirin     Akt     cardiac hypertrophy     GSK-3β     Wnt/β-catenin    

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Integrated management of cardiac failure: the cardiac failure clinic

Daniel LOISANCE

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 20-25 doi: 10.1007/s11684-011-0106-1

Abstract:

The prevalence of the risk factors and the risk of cardiac failure are both increasing in China.The wide range of clinical presentations of cardiac failure (acute or chronic) and of therapeutic approachesintegration within the same structure of the various experts involved in the diagnosis and the treatment of cardiacIn these centers, collaboration should replace competition between the medical and the surgical cardiac

Keywords： cardiac failure     cardiac transplantation     mechanical circulatory support    

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Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Frontiers of Medicine 2023, Volume 17, Issue 5,   Pages 939-956 doi: 10.1007/s11684-023-0987-9

Abstract: To this end, 12 645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 miceThree cardiac developmental paths were identified: two switching to cardiomyocytes (CM) maturation withThese findings could improve the understanding of MNDCM heterogeneity and cardiac development, thus providingnew clues for approaches to effective cardiac regeneration.

Keywords： mononuclear diploid cardiomyocytes     cell–cell communication     cardiac fibroblast     single-cell RNA sequencing     cardiac regeneration    

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mA reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation

Frontiers of Medicine 2024, Volume 18, Issue 3,   Pages 499-515 doi: 10.1007/s11684-023-1052-4

Abstract: Cardiac fibrosis caused by ventricular remodeling and dysfunction such as post-myocardial infarctionin vivo and transforming growth factor-β (TGF-β)-activated cardiacOur results demonstrated that silencing YTHDF1 in mouse hearts can significantly restore impaired cardiacfunction and attenuate myocardial fibrosis, whereas YTHDF1 overexpression could further enhance cardiacβ-Smad2/3 signaling pathway, thereby aggravating the occurrence and development of cardiac

Keywords： cardiac fibrosis     YTHDF1     AXL     ZBED6     heart failure    

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Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 58-67 doi: 10.1007/s11684-022-0937-y

Abstract: Kaplan–Meier estimates showed that recipients with cardiac abnormalities had a significantly increasedAfter adjusting for potential confounders, cardiac abnormality was shown to be independently associated

Keywords： cardiac disease     mortality     aged population     lung transplantation    

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Management of mantle cell leukemia with cardiac involvement leading to cardiogenic shock

Muhammad Furqan,Yamei Chen,Akintunde Akinleye,Judy Sarungbam,Alan Gass,Karen Seiter,Delong Liu

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 254-258 doi: 10.1007/s11684-014-0319-1

Abstract: Here we report a case of cardiac involvement by mantle cell leukemia leading to cardiogenic shock which

Keywords： mantle cell lymphoma     bendamustine     cardiogenic shock    

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Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 445-455 doi: 10.1007/s11684-014-0378-3

Abstract: The purpose of this study was to investigate the effects of PDE5 inhibitor on cardiac fibrosis.In control mice, 4 weeks of TAC induced significant cardiac dysfunction, cardiac fibrosis, and cardiacSildenafil treatment markedly prevented TAC-induced cardiac dysfunction, cardiac fibrosis and cardiacIn isolated cardiac fibroblasts, sildenafil blocked TGF-β1-induced cardiac fibroblast transformationthrough CREB activation in cardiac fibroblasts.

Keywords： PDE5     cardiac fibrosis     TGF-β     CREB    

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PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 399-403 doi: 10.1007/s11684-014-0380-9

Abstract:

We review here the novel cardiac protective effects of the multifunctional enzyme, p21-activated kinasereview, we assemble an overview of the recent findings on PAK1 signaling in the heart, particularly its cardiacWe present a model for PAK1 signaling that provides a mechanism for specifically affecting cardiac cellularWe discuss the anti-adrenergic and antihypertrophic cardiac protective effects of PAK1, as well as its

Keywords： p21-activated kinase 1 (PAK1)     heart    

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Tissue Engineering to Restore Cardiac Function

Richard D. Weisel

Engineering 2022, Volume 13, Issue 6,   Pages 13-17 doi: 10.1016/j.eng.2021.06.013

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Right coronary occlusion following transcatheter aortic valve implantation: two case reports

Gang Zhang,Jun Luo,Guo Chen

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 351-355 doi: 10.1007/s11684-016-0465-8

Abstract:

This paper discusses two male patients with severe aortic stenosis, whose right coronary arteries (RCA) were completely occluded during transcatheter aortic valve implantation (TAVI), leading to fatal hemodynamic disorder. Occlusions of RCA complicated by TAVI are rare. In addition, emergency cardiopulmonary bypass (CPB) played a critical role in rescuing our second patient. Both patients were admitted for “severe aortic stenosis,” and TAVIs were performed. The first patient’s blood pressure immediately dropped to 70/40 mmHg after the balloon expansion and did not increase much after the administration of aramine or fluid therapy. He did not receive emergency surgery and died after 1.5 h of resuscitation. The second patient’s blood pressure fluctuated greatly for several minutes after the valve implantation, ranging from 170/100 mmHg to 60/40 mmHg. Angiography revealed a total occlusion of RCA. Thoracic surgery with CPB was performed, and the patient survived.

Keywords： aortic stenosis     transcatheter aortic valve implantation     right coronary occlusion     cardiac group    

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Cardiac Remote Conditioning and Clinical Relevance: All Together Now! Review

Kristin Luther,Yang Song,Yang Wang,Xiaoping Ren,W. Keith Jones

Engineering 2015, Volume 1, Issue 4,   Pages 490-499 doi: 10.15302/J-ENG-2015117

Abstract: cardioprotective “conditioning” phenomena represent activation from different entry points of a cardiacand nociceptive stimuli is emerging as a potential non-ischemic and non-traumatic means to initiate cardiac

Keywords： remote cardioprotection     cardiac conditioning     non-ischemic conditioning     peripheral nociceptive stimulus    

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Challenges and opportunities in improving left ventricular remodelling and clinical outcome following surgical and trans-catheter aortic valve replacement

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 416-437 doi: 10.1007/s11684-021-0852-7

Abstract: LV hypertrophy and myocardial fibrosis remains as the structural and morphological focus in this endeavourregurgitation along with therapy of angiotensin receptor blockade will improve patient outcome by facilitating hypertrophy

Keywords： surgical aortic valve replacement     trans-catheter aortic valve implantation     left ventricular hypertrophy    

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Title Author Date Type Operation

Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Journal Article

lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression

Journal Article

lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1–mitochondrial complex

Journal Article

Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Journal Article

Integrated management of cardiac failure: the cardiac failure clinic

Daniel LOISANCE

Journal Article

Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Journal Article

mA reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation

Journal Article

Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients

Journal Article

Management of mantle cell leukemia with cardiac involvement leading to cardiogenic shock

Muhammad Furqan,Yamei Chen,Akintunde Akinleye,Judy Sarungbam,Alan Gass,Karen Seiter,Delong Liu

Journal Article

Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Journal Article

PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Journal Article

Tissue Engineering to Restore Cardiac Function

Richard D. Weisel

Journal Article

Right coronary occlusion following transcatheter aortic valve implantation: two case reports

Gang Zhang,Jun Luo,Guo Chen

Journal Article

Cardiac Remote Conditioning and Clinical Relevance: All Together Now!

Kristin Luther,Yang Song,Yang Wang,Xiaoping Ren,W. Keith Jones

Journal Article

Challenges and opportunities in improving left ventricular remodelling and clinical outcome following surgical and trans-catheter aortic valve replacement

Journal Article