Resource Type

Journal Article 320

Year

2023 25

2022 30

2021 29

2020 24

2019 12

2018 13

2017 16

2016 20

2015 22

2014 25

2013 12

2012 15

2011 13

2010 12

2009 17

2008 8

2007 10

2006 1

2003 1

2001 1

open ︾

Keywords

vaccine 11

humic acid 9

DNA 7

COVID-19 6

DNA damage 6

DNA methylation 6

Vaccine 5

biodiesel 5

2 4

SARS-CoV-2 4

1 3

β-glucuronidase 2

Adsorption 2

Chlorination 2

H7N9 2

MoS2 2

acute myeloid leukemia 2

adsorption 2

apoptosis 2

open ︾

Search scope:

排序： Display mode:

Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Strategic Study of CAE 2021, Volume 23, Issue 4,   Pages 153-161 doi: 10.15302/J-SSCAE-2021.04.018

Abstract: Considering the urgent needs of coronavirus disease 2019 (COVID-19) epidemic prevention and control, nucleic acidvaccine has attracted great attention in the vaccine research and development (R&D) field owingParticularly, the R&D process of messenger RNA (mRNA) vaccine has significantly accelerated, andthe mRNA vaccine was approved for the first time to be marketed and used in humans.This article first summarizes the R&D status of nucleic acid vaccines from the aspects of related

Keywords： nucleic acid vaccine     deoxyribonucleic acid (DNA) vaccine     ribonucleic acid (RNA) vaccine     messengerRNA (mRNA) vaccine     coronavirus disease 2019 (COVID-19)     cancer    

HTML PDF Collect
Share

Adsorption of herring sperm DNA onto pine sawdust biochar: Thermodynamics and site energy distribution

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 11, doi: 10.1007/s11783-022-1579-7

Abstract:

● Adsorption of environmental deoxyribonucleic acid on biochar was

Keywords： Environmental deoxyribonucleic acid     Antibiotic resistance genes     Biochar     Adsorption thermodynamics    

HTML PDF Collect
Share

Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 51-57 doi: 10.1007/s11684-008-0010-5

Abstract: After subcutaneous injection with SART3 gene vaccine, cytotoxic T lymphocyte (CTL) activity was measuredAnother group was treated with the vaccine after tumor implantation.It was found that human SART3 DNA vaccine can elicit a specific CTL reaction from the mouse splenocytesThe vaccine also shows activity in tumor treatment.We conclude that the human SART3 DNA vaccine can induce antitumor ability against tumor cells expressing

Keywords： antitumor therapy     occurrence     implantation     DNA vaccine     SART3 DNA    

HTML PDF Collect
Share

Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 6,   Pages 973-984 doi: 10.1007/s11705-021-2123-1

Abstract: Here, because of the varying oleic to linoleic acid ratio, soybean oil, peanut oil, and olive oil wereof oil phases and emulsion stability were unravelled, which showed that a higher oleic to linoleic acid

Keywords： pickering emulsion     vaccine adjuvant     alum-stabilised emulsion     oleic to linoleic acid ratio     stability    

HTML PDF Collect
Share

Vaccine therapies for chronic hepatitis B: can we go further?

Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 17-23 doi: 10.1007/s11684-014-0313-7

Abstract: dysregulations and defects in chronic hepatitis B patients, this paper presents the peptide and protein-based, DNA-based

Keywords： chronic hepatitis B     therapeutic     antigen-antibody complexes     DNA     vaccine    

HTML PDF Collect
Share

Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 390-395 doi: 10.1007/s11684-009-0087-5

Abstract: It was employed to evaluate immune response of the mice inoculated doubly with the DNA vaccine.The serum titer of IgG antibody against LMP2 epitope in the mice immunized with the DNA vaccine encodingIn conclusion, the EBV DNA vaccine can induce a strong humoral immune response in mice.

Keywords： Epstein-Barr virus     latent membrane protein 2     nasopharyngeal carcinoma     humoral immunity    

HTML PDF Collect
Share

Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 196-202 doi: 10.1007/s11705-016-1565-3

Abstract: strategy for 3-D structure determination of macromolecules, such as nucleic acids and protein-nucleic acidsuccessfully developed synthesis and strategy of selenium-derivatized nucleic acids (SeNA) for nucleic acid

Keywords： selenium     DNA     RNA     nucleic acid     crystallization    

HTML PDF Collect
Share

Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3,   Pages 275-286 doi: 10.1007/s11705-011-1203-z

Abstract: In the case of nucleic acid therapy, non-viral carriers face several biological barriers during the deliveryand conjugation of multifunctional polymeric structures for the utilization as “tailor-made” nucleic acid

Keywords： conjugate     DNA     gene transfer     polymer     RNA     targeting    

HTML PDF Collect
Share

Profiling influences of gene overexpression on heterologous resveratrol production in

Duo Liu,Bingzhi Li,Hong Liu,Xuejiao Guo,Yingjin Yuan

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 117-125 doi: 10.1007/s11705-016-1601-3

Abstract: Single-gene overexpression and DNA assembly-directed multigene overexpression affect the production ofresveratrol as well as its precursor -coumaric acid.

Keywords： resveratrol     aromatic amino acid     DNA assembly     metabolic engineering     gene overexpression    

HTML PDF Collect
Share

Engineering DNA Materials for Sustainable Data Storage Using a DNA Movable-Type System Article

Zi-Yi Gong, Li-Fu Song, Guang-Sheng Pei, Yu-Fei Dong, Bing-Zhi Li, Ying-Jin Yuan

Engineering 2023, Volume 29, Issue 10,   Pages 130-136 doi: 10.1016/j.eng.2022.05.023

Abstract:

DNA molecules are green materials with great potential for high-density and long-term data storageHowever, the current data-writing process of DNA data storage via DNA synthesis suffers from high costsHere, we developed a DNA movable-type storage system that can utilize DNA fragments pre-produced by cellIn this system, these pre-generated DNA fragments, referred to herein as "DNA movable types,"the costly and environmentally hazardous process of de novo DNA synthesis.

Keywords： 合成生物学     DNA信息存储     DNA活字存储系统     经济性DNA数据存储    

HTML PDF Collect
Share

Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 30-42 doi: 10.1007/s11684-019-0721-9

Abstract: However, vaccine development has remained challenging.in broadly neutralizing monoclonal antibodies (bNAbs) has led to the development of multiple novel vaccineOur review aims to highlight these discoveries and rejuvenate our endeavor in HIV-1 vaccine design and

Keywords： HIV-1     broadly neutralizing antibodies     Env conformational states     vaccine design     SOSIP    

HTML PDF Collect
Share

Protection of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective

Frontiers of Medicine doi: 10.1007/s11684-023-0995-9

Abstract: The protection against SARS-CoV-2 infection of the Sinopharm vaccine was similar in participants with

Keywords： COVID-19     Sinopharm/BBIBP vaccine     immunocompromised patients     real-world    

HTML PDF Collect
Share

The role of PARP1 in the DNA damage response and its application in tumor therapy

Zhifeng Wang, Fengli Wang, Tieshan Tang, Caixia Guo

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 156-164 doi: 10.1007/s11684-012-0197-3

Abstract: ADP-ribosyl)ation of many key proteins in vivo and thus plays important roles in multiple DNAThe present review will focus on recent progress on the role of PARP1 in the DNA damage response andresistance of BRCA-deficient tumors to PARP inhibitors is also briefly discussed from the perspective of DNA

Keywords： PARP1     synthetic lethality     PARP inhibitor     DNA repair     cancer     NHEJ    

HTML PDF Collect
Share

virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 480-489 doi: 10.1007/s11684-017-0594-8

Abstract: Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses thanif superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine

Keywords： human immunodeficiency virus type I     superinfection     incidence     immune response    

HTML PDF Collect
Share

Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 201-216 doi: 10.1007/s11684-014-0324-4

Abstract: AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA doubleThus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repairedregulate the specificity of AID targeting and the repair pathways responsible for processing AID-initiated DNA

Keywords： class switch recombination     somatic hypermutation     activation-induced deaminase     DNA repair     genomic instability    

HTML PDF Collect
Share

Title Author Date Type Operation

Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Journal Article

Adsorption of herring sperm DNA onto pine sawdust biochar: Thermodynamics and site energy distribution

Journal Article

Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Journal Article

Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine

Journal Article

Vaccine therapies for chronic hepatitis B: can we go further?

Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan

Journal Article

Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Journal Article

Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Journal Article

Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Journal Article

Profiling influences of gene overexpression on heterologous resveratrol production in

Duo Liu,Bingzhi Li,Hong Liu,Xuejiao Guo,Yingjin Yuan

Journal Article

Engineering DNA Materials for Sustainable Data Storage Using a DNA Movable-Type System

Zi-Yi Gong, Li-Fu Song, Guang-Sheng Pei, Yu-Fei Dong, Bing-Zhi Li, Ying-Jin Yuan

Journal Article

Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Journal Article

Protection of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective

Journal Article

The role of PARP1 in the DNA damage response and its application in tumor therapy

Zhifeng Wang, Fengli Wang, Tieshan Tang, Caixia Guo

Journal Article

virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Journal Article

Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Journal Article