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Challenges and opportunities in improving left ventricular remodelling and clinical outcome following

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 416-437 doi: 10.1007/s11684-021-0852-7

Abstract: efficient valve haemodynamically, with low procedural complications that allows favourable remodelling of leftventricular (LV) structure and function.LV hypertrophy and myocardial fibrosis remains as the structural and morphological focus in this endeavourregurgitation along with therapy of angiotensin receptor blockade will improve patient outcome by facilitating hypertrophy

Keywords： surgical aortic valve replacement     trans-catheter aortic valve implantation     left ventricular hypertrophyand fibrosis     myocardial force-velocity relationship     His-Purkinje pacing     renin-angiotensin    

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Echocardiographic Measurements in Normal Chinese Adults (EMINCA) II focusing on left ventricular andleft atrial size and function by three-dimensional echocardiography

Frontiers of Medicine doi: 10.1007/s11684-023-1045-3

Abstract: This study was designed to establish the normal values of 3D-left ventricular (LV) and left atrial (LA

Keywords： three-dimensional echocardiography     left ventricle     left atrium     normal reference values     Chinese adults    

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Incremental value of contrast echocardiography in the diagnosis of left ventricular noncompaction

Xiaoxiao Zhang,Li Yuan,Linli Qiu,Yali Yang,Qing Lv,Lin Li,Jing Wang,Lin He,Li Zhang,Xinfang Wang,Mingxing Xie,Xu Yu Jin

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 499-506 doi: 10.1007/s11684-016-0473-8

Abstract:

Contrast echocardiography with left ventricular opacification (LVO) improves the definition of endocardiumThis study was aimed to determine whether LVO offered added diagnostic value in noncompaction of leftventricular myocardium (NCVM).

Keywords： echocardiography     left ventricular noncompaction cardiomyopathy     echo contrast media    

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Prognostic value of fasting glucose on the risk of heart failure and left ventricular systolic dysfunction

Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 70-78 doi: 10.1007/s11684-020-0749-x

Abstract: To investigate the effect of fasting blood glucose (FBG) on the risk of heart failure (HF) and left ventricular

Keywords： myocardial infarction     percutaneous coronary intervention     diabetes mellitus     fasting glucose     heart failure    

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Assessment of global and regional left ventricular twist and displacement in anterior myocardial infarction

Wei HAN MM, Ming-Xing XIE MD, Qing LV MD, Xin-Fang WANG MD, Li ZHANG MM,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 71-76 doi: 10.1007/s11684-010-0006-9

Abstract: development of 2-dimensional strain (2D strain) imaging can provide a powerful alternative for assessing leftventricular (LV) torsion.This study was conducted to evaluate the global and regional left ventricular twist by 2D strain in patientsThis study demonstrated that 2D strain has a potential ability for quantification of left ventricular

Keywords： echocardiography     twist     two-dimensional strain imaging     coronary artery disease    

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Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 19-24 doi: 10.1007/s11684-008-0005-2

Abstract: effects of RNA interference (RNAi) targeting angiotensin 1a receptor (AT1a) on blood pressure and cardiac hypertrophyThe ratio of left ventricle weight to body weight (LV/BW) of the rats in pAT1a-shRNA1, pAT1a-shRNA2,targeting AT1a receptor inhibits the development of renovascular hypertension and the accompanying cardiac hypertrophy

Keywords： therapy     Sprague     administration     cardiac hypertrophy     valsartan    

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Drug-coated balloon-only strategy for percutaneous coronary intervention of left main coronary artery

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 75-84 doi: 10.1007/s11684-022-0950-1

Abstract: all consecutive patients who underwent percutaneous coronary intervention (PCI) for a de novo leftTo best of our knowledge, no previous studies of DCB-only strategy of treating de novo left main8.6, 72% male), 52% of whom had acute coronary syndrome, underwent leftNo procedural mortality and no acute closures of the treated left main occurred.Left main PCI with the DCB only-strategy is safe leading to acceptable MACE and low TLR rates at one

Keywords： drug-coated balloon     left main     high bleeding risk     predilatation     calcifield lesion     percutaneous coronary    

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lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression

Frontiers of Medicine 2024, Volume 18, Issue 3,   Pages 484-498 doi: 10.1007/s11684-023-1036-4

Abstract: The decreased transcriptional activity of ZNF593-AS has also been detected in cardiac hypertrophy.However, the function of ZNF593-AS in cardiac hypertrophy remains unclear.Herein, we report that the expression of ZNF593-AS reduced in a mouse model of left ventricular hypertrophyIn vivo, ZNF593-AS aggravated pressure overload–induced cardiac hypertrophy in knockout mice.cardiomyocyte-specific transgenic mice (ZNF593-AS MHC-Tg) exhibited attenuated TAC-induced cardiac hypertrophy

Keywords： lncRNA     ZNF593-AS     cardiac hypertrophy     Mfn2     oxidative phosphorylation.    

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lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1–mitochondrial complex

Frontiers of Medicine doi: 10.1007/s11684-024-1065-7

Abstract: Pathological cardiac hypertrophy, a major contributor to heart failure, is closely linked to mitochondrialThe suppression of Gm20257 by using small interfering RNAs significantly induced cardiomyocyte hypertrophyadeno-associated viral vector-9 mitigated angiotensin II–induced hypertrophic phenotypes in neonatal mouse ventricularcells or alleviated cardiac hypertrophy in a mouse TAC model respectively, thus restoring cardiac functionPGC-1α–mitochondrial complex IV axis, offering a novel approach for attenuating pathological cardiac hypertrophy

Keywords： lncRNA Gm20257     cardiac hypertrophy     PGC-1α     mitochondrial complex IV     ATP    

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Temporal echocardiography findings in patients with fulminant myocarditis: beyond ejection fraction decline

Houjuan Zuo, Rui Li, Fei Ma, Jiangang Jiang, Kun Miao, Haojie Li, Eike Nagel, Marijana Tadic, Hong Wang, Dao Wen Wang

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 284-292 doi: 10.1007/s11684-019-0713-9

Abstract: In this study, changes in the left ventricular ejection fraction (LVEF) and global and layer-specificconclusion, FM patients who received mechanical circulatory supports exhibited steep improvement in ventricular

Keywords： fulminant myocarditis     acute myocarditis     2D speckle tracking echocardiography     left ventricular function    

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Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis

Frontiers of Medicine 2024, Volume 18, Issue 3,   Pages 538-557 doi: 10.1007/s11684-024-1079-1

Abstract: Schistosoma infection is one of the major causes of liver fibrosis.Emerging roles of hepatic progenitor cells (HPCs) in the pathogenesis of liver fibrosis have been identifiedNevertheless, the precise mechanism underlying the role of HPCs in liver fibrosis in schistosomiasisThis study examined how autophagy in HPCs affects schistosomiasis-induced liver fibrosis by modulatingBlocking autophagy by the autophagy inhibitor chloroquine (CQ) significantly diminished liver fibrosis

Keywords： schistosomiasis     hepatic progenitor cell     autophagy     extracellular vesicle     fibrosis     miRNA    

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mA reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation

Frontiers of Medicine 2024, Volume 18, Issue 3,   Pages 499-515 doi: 10.1007/s11684-023-1052-4

Abstract: Cardiac fibrosis caused by ventricular remodeling and dysfunction such as post-myocardial infarction(TGF-β)-activated cardiac fibroblasts in vitro were performed to establish fibrosisYTHDF1 in mouse hearts can significantly restore impaired cardiac function and attenuate myocardial fibrosiswhereas YTHDF1 overexpression could further enhance cardiac dysfunction and aggravate the occurrence of ventricularOur results revealed that YTHDF1 could serve as a potential therapeutic target for myocardial fibrosis

Keywords： cardiac fibrosis     YTHDF1     AXL     ZBED6     heart failure    

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Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 445-455 doi: 10.1007/s11684-014-0378-3

Abstract: Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failureThe purpose of this study was to investigate the effects of PDE5 inhibitor on cardiac fibrosis.We assessed cardiac fibrosis and pathology in mice subjected to transverse aortic constriction (TAC).In control mice, 4 weeks of TAC induced significant cardiac dysfunction, cardiac fibrosis, and cardiacSildenafil treatment markedly prevented TAC-induced cardiac dysfunction, cardiac fibrosis and cardiac

Keywords： PDE5     cardiac fibrosis     TGF-β     CREB    

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Sudden death due to arrhythmogenic right ventricular cardiomyopathy: Two case reports

CHEN Xinshan, ZHANG Yigu, RAO Guangxun, HUANG Guangzhao

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 338-342 doi: 10.1007/s11684-007-0065-8

Abstract: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a kind of primary myocardial disease characterizedby the regional or global replacement of right ventricular myocardium by fatty and fibrolipomatous tissuesOne of the victims had extensive and severe pathological changes in his heart involving the left ventricularwall as well as the ventricular septum and the right atrium.Not only was there a global fatty and fibrolipomatous tissue replacement of the right ventricular myocardia

Keywords： sarcoplasmic coagulation     acquired     ventricular myocardium     sino-atrial     autopsied    

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Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on

Zhen Zhang, Na Jiang, Zhaohui Ni

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 349-358 doi: 10.1007/s11684-017-0571-2

Abstract: morphologic and functional changes to the peritoneal membrane (PM), which is defined as peritoneal fibrosisInflammation and angiogenesis are key events during the pathogenesis of peritoneal fibrosis.This review discusses the pathophysiology of peritoneal fibrosis and recent research progress on key

Keywords： peritoneal dialysis     peritoneal fibrosis     inflammation     angiogenesis    

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Title Author Date Type Operation

Challenges and opportunities in improving left ventricular remodelling and clinical outcome following

Journal Article

Echocardiographic Measurements in Normal Chinese Adults (EMINCA) II focusing on left ventricular andleft atrial size and function by three-dimensional echocardiography

Journal Article

Incremental value of contrast echocardiography in the diagnosis of left ventricular noncompaction

Xiaoxiao Zhang,Li Yuan,Linli Qiu,Yali Yang,Qing Lv,Lin Li,Jing Wang,Lin He,Li Zhang,Xinfang Wang,Mingxing Xie,Xu Yu Jin

Journal Article

Prognostic value of fasting glucose on the risk of heart failure and left ventricular systolic dysfunction

Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang

Journal Article

Assessment of global and regional left ventricular twist and displacement in anterior myocardial infarction

Wei HAN MM, Ming-Xing XIE MD, Qing LV MD, Xin-Fang WANG MD, Li ZHANG MM,

Journal Article

Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Journal Article

Drug-coated balloon-only strategy for percutaneous coronary intervention of left main coronary artery

Journal Article

lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression

Journal Article

lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1–mitochondrial complex

Journal Article

Temporal echocardiography findings in patients with fulminant myocarditis: beyond ejection fraction decline

Houjuan Zuo, Rui Li, Fei Ma, Jiangang Jiang, Kun Miao, Haojie Li, Eike Nagel, Marijana Tadic, Hong Wang, Dao Wen Wang

Journal Article

Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis

Journal Article

mA reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation

Journal Article

Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Journal Article

Sudden death due to arrhythmogenic right ventricular cardiomyopathy: Two case reports

CHEN Xinshan, ZHANG Yigu, RAO Guangxun, HUANG Guangzhao

Journal Article

Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on

Zhen Zhang, Na Jiang, Zhaohui Ni

Journal Article