Resource Type

Journal Article 175

Year

2024 8

2023 20

2022 15

2021 13

2020 9

2019 3

2018 11

2017 6

2016 5

2015 4

2014 5

2013 4

2012 6

2011 4

2010 7

2009 4

2008 8

2007 8

2006 5

2005 8

open ︾

Keywords

open complex giant system 6

complex system 3

complex systems 3

meta-synthesis management 3

3D printing 2

Complex network 2

Complex networks 2

Complex system 2

Complex systems 2

Deep learning 2

Hong Kong-Zhuhai-Macao Bridge 2

Marxist philosophy 2

Meta-synthesis 2

benefit maximization 2

complex network 2

computer simulation 2

sustainable development 2

urban complex 2

2-ethyl hexyl phosphonic acid-mono-2-ethyl hexyl ester 1

open ︾

Search scope:

排序： Display mode:

lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1–mitochondrial complexIV axis

Frontiers of Medicine doi: 10.1007/s11684-024-1065-7

Abstract: Importantly, Gm20257 restored mitochondrial complex IV level and enhanced mitochondrial function.complex IV.This interaction was demonstrated to rescue the reduction of mitochondrial complex IV induced by hypertrophicThese findings suggest that Gm20257 improves mitochondrial function through the PGC-1α–mitochondrialcomplex IV axis, offering a novel approach for attenuating pathological cardiac hypertrophy.

Keywords： lncRNA Gm20257     cardiac hypertrophy     PGC-1α     mitochondrial complex IV     ATP    

HTML PDF Collect

Association of gene variants with juvenile amyotrophic lateral sclerosis

Frontiers of Medicine 2024, Volume 18, Issue 1,   Pages 68-80 doi: 10.1007/s11684-023-1005-y

Abstract: characterized by progressive degeneration of motor neurons, and it demonstrates high clinical heterogeneity and complexA decreased number of mitochondria, swollen mitochondria, lower expression of ND1, decreased mitochondrialcomplex I activities, lower mitochondrial aerobic respiration, and a high level of ROS were observed

Keywords： TRMT2B     amyotrophic lateral sclerosis     mitochondrial complex I     tRNA methylation     reactive oxygen    

HTML PDF Collect

hydrophobic environment triggering reactive fluorescence probe to real-time monitor mitochondrial DNA

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 92-102 doi: 10.1007/s11705-021-2063-9

Abstract: Mitochondrial DNA has a special structure that is prone to damage resulting in many serious diseases,Therefore, the rapid and specific monitoring of mitochondrial DNA damage is urgently needed for biologicalIn this design, MBI-CN conjugates to mitochondrial DNA without causing additional damages.Give that the specific and rapid response of MBI-CN does not cause additional damages to mitochondrialDNA, it is a potentially effective detection tool for the real-time monitoring of mitochondrial DNA

Keywords： hydrolysis reaction     mitochondrial DNA damage     in situ hydrophobic environment trigger     fluorescence    

HTML PDF Collect

Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Frontiers of Medicine 2023, Volume 17, Issue 6,   Pages 1219-1235 doi: 10.1007/s11684-023-0983-0

Abstract: Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Keywords： mitochondrial fission Ca     Berberine alleviates myocardial     murine model HFpEF    

HTML PDF Collect

Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 216-226 doi: 10.1007/s11684-022-0920-7

Abstract: Hepatocellular carcinoma (HCC), which makes up the majority of liver cancer, is induced by the infection of hepatitis B/C virus. Biomarkers are needed to facilitate the early detection of HCC, which is often diagnosed too late for effective therapy. The tRNA-derived small RNAs (tsRNAs) play vital roles in tumorigenesis and are stable in circulation. However, the diagnostic values and biological functions of circulating tsRNAs, especially for HCC, are still unknown. In this study, we first utilized RNA sequencing followed by quantitative reverse-transcription PCR to analyze tsRNA signatures in HCC serum. We identified tRF-Gln-TTG-006, which was remarkably upregulated in HCC serum (training cohort: 24 HCC patients vs. 24 healthy controls). In the validation stage, we found that tRF-Gln-TTG-006 signature could distinguish HCC cases from healthy subjects with high sensitivity (80.4%) and specificity (79.4%) even in the early stage (Stage I: sensitivity, 79.0%; specificity, 74.8%; 155 healthy controls vs. 153 HCC patients from two cohorts). Moreover, in vitro studies indicated that circulating tRF-Gln-TTG-006 was released from tumor cells, and its biological function was predicted by bioinformatics assay and validated by colony formation and apoptosis assays. In summary, our study demonstrated that serum tsRNA signature may serve as a novel biomarker of HCC.

Keywords： tsRNA     biomarker     hepatocarcinoma    

HTML PDF Collect

Conserved gene arrangement in the mitochondrial genomes of barklouse families Stenopsocidae and Psocidae

Xiaochen LIU, Hu LI, Yao CAI, Fan SONG, John-James WILSON, Wanzhi CAI

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 358-365 doi: 10.15302/J-FASE-2017158

Abstract: Substantial variation in gene organization and arrangement has been reported for sequenced mitochondrial

Keywords： gene rearrangement     mitochondrial genome     Psocoptera     Stenopsocidae     TDRL model    

HTML PDF Collect

Modeling of Ce(IV) transport through a dispersion flat combined liquid membrane with carrier P507

Liang PEI,Liming WANG,Zhanying MA

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 4,   Pages 503-509 doi: 10.1007/s11783-013-0540-1

Abstract: A mathematical model for the transport of Ce(IV) from hydrochloric acid solutions through dispersionIn this work, the system is considered to be in a transient state, and chemical reaction between Ce(IVThe experimental and simulated Ce(IV) extractions showed similar tendencies for a high Ce(IV) concentrationand acidity case.The model results indicate that high initial Ce(IV) concentrations and acidity bothhave detrimental effects on Ce(IV) extraction and stripping.

Keywords： membrane (DFCLM)     dispersion phase     feed phase     2-ethyl hexyl phosphonic acid-mono-2-ethyl hexyl ester     Ce (IV    

HTML PDF Collect

Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain

Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen, Zhifei Wang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 79-90 doi: 10.1007/s11684-020-0783-8

Abstract: Astragaloside IV (ASIV) is the major bioactive ingredient of , a Chinese herbal medicine, and possesses

Keywords： astragaloside IV     brain ischemia     natural killer cells     histone deacetylase     nuclear factor-κB    

HTML PDF Collect

Vanadium(IV) solvent extraction enhancement in high acidity using di-(2-ethylhexyl)phosphoric acid with

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 1,   Pages 56-67 doi: 10.1007/s11705-022-2185-8

Abstract: Separation of vanadium from black shale leaching solution at low pH is very meaningful, which can effectively avoid the generation of alkali neutralization slag and the resulting vanadium loss. In this study, coordination mechanism of vanadium in acid leaching solution at low pH was investigated with the intervention of chloride ions. Under the conditions of pH 0.8, di-(2-ethylhexyl)phosphoric acid concentration of 20%, phase ratio of 1:2, and extraction time of 8 min, the vanadium extraction could reach 80.00%. The Fourier transform infrared and electrospray ionization results reveal that, despite the fact that the chloride ion in the leachate could significantly promote vanadium extraction, the chloride ion does not enter the organic phase, indicating an intriguing phenomenon. Among Cl−–V, SO42−–V, and H2O–V, the V–Cl bond is longer and the potential difference between coordinate ions and vanadium is smaller. Therefore, VO2+ gets easily desorbed with chloride ions and enter the organic phase. At the same time, the hydrogen ions of di-(2-ethylhexyl)phosphoric acid also enter the water phase more easily, which reduces the pH required for the extraction reaction.

Keywords： vanadium     black shale     solvent extraction     high acidity extraction    

HTML PDF Collect

N-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probes

Yan Shi, Fangjun Huo, Yongkang Yue, Caixia Yin

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 64-71 doi: 10.1007/s11705-021-2048-8

Abstract: In addition, cell imaging shows that this probe can be used for the mitochondrial targeted detection

Keywords： heterocyclic compound     hydrogen sulfide     ratiometric     mitochondrial targeted    

HTML PDF Collect

Visible light induces bacteria to produce superoxide for manganese oxidation

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 2, doi: 10.1007/s11783-023-1619-y

Abstract:

● Term of manganese-oxidizing microorganisms should be reconsidered.

Keywords： Mn(II) oxidation     Manganese-oxidizing bacteria     Reactive oxygen species     Mn(III/IV) oxides    

HTML PDF Collect

NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 177-184 doi: 10.1007/s11684-010-0038-1

Abstract: Direct DNA-sequencing analysis techniques were used to detect mitochondrial sequence variants between

Keywords： nucleoside reverse transcriptase inhibitors     human immunodeficiency virus     mitochondrial DNA     D loop     mutation    

HTML PDF Collect

GID complex regulates the differentiation of neural stem cells by destabilizing TET2

Frontiers of Medicine 2023, Volume 17, Issue 6,   Pages 1204-1218 doi: 10.1007/s11684-023-1007-9

Abstract: interacts with the core subunits of the glucose-induced degradation-deficient (GID) ubiquitin ligase complex, an evolutionarily conserved ubiquitin ligase complex and is ubiquitinated by itself.The protein levels of GID complex subunits increased reciprocally with TET2 level upon NSC differentiationThe silencing of the core subunits of the GID complex, including WDR26 and ARMC8, attenuated the ubiquitinationOur results illustrated that the GID complex negatively regulates TET2 protein stability, further modulates

Keywords： TET2     GID complex     neural stem cells     differentiation of neurons    

HTML PDF Collect

Unraveling the complex roles of macrophages in obese adipose tissue: an overview

Frontiers of Medicine 2024, Volume 18, Issue 2,   Pages 205-236 doi: 10.1007/s11684-023-1033-7

Abstract: Unraveling the complex roles of macrophages in obese adipose tissue: an overview

Keywords： roles macrophages adipose    

HTML PDF Collect

Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 319-332 doi: 10.1007/s11684-017-0569-9

Abstract: However, this disease is multifactorial, and its mechanism is poorly understood due to the complex pathogenesisthe aspects of immune inflammation response, epithelial–mesenchymal transition, apoptosis and mitochondrial

Keywords： diabetic nephropathy     immune inflammatory response     epithelial–mesenchymal transition     apoptosis     mitochondrial    

HTML PDF Collect

Title Author Date Type Operation

lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1–mitochondrial complexIV axis

Journal Article

Association of gene variants with juvenile amyotrophic lateral sclerosis

Journal Article

hydrophobic environment triggering reactive fluorescence probe to real-time monitor mitochondrial DNA

Journal Article

Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Journal Article

Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

Journal Article

Conserved gene arrangement in the mitochondrial genomes of barklouse families Stenopsocidae and Psocidae

Xiaochen LIU, Hu LI, Yao CAI, Fan SONG, John-James WILSON, Wanzhi CAI

Journal Article

Modeling of Ce(IV) transport through a dispersion flat combined liquid membrane with carrier P507

Liang PEI,Liming WANG,Zhanying MA

Journal Article

Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain

Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen, Zhifei Wang

Journal Article

Vanadium(IV) solvent extraction enhancement in high acidity using di-(2-ethylhexyl)phosphoric acid with

Journal Article

N-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probes

Yan Shi, Fangjun Huo, Yongkang Yue, Caixia Yin

Journal Article

Visible light induces bacteria to produce superoxide for manganese oxidation

Journal Article

NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Journal Article

GID complex regulates the differentiation of neural stem cells by destabilizing TET2

Journal Article

Unraveling the complex roles of macrophages in obese adipose tissue: an overview

Journal Article

Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Journal Article