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Linking elements to outcomes of knowledge transfer in the project environment: Current review and future

Frontiers of Engineering Management 2022, Volume 9, Issue 2,   Pages 221-238 doi: 10.1007/s42524-022-0195-3

Abstract: However, the current research on the elements and outcomes of knowledge transfer (KT) in the projectThis study aims to conduct comprehensive research to determine and link the elements and outcomes ofFive-dimensional transfer elements and two-dimensional transfer outcomes were then identified and analyzedLastly, the relationships between the transfer elements and outcomes were gathered to create a comprehensiveThis study builds a theoretical framework linking transfer elements to outcomes that can serve as a basis

Keywords: knowledge transfer     knowledge management     project management     project environment     literature review    

Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy

Li Zhuo, Nianrong Zhang, Guming Zou, Dapeng Chen, Wenge Li

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 386-392 doi: 10.1007/s11684-017-0574-z

Abstract: Predictive factors for diabetic nephropathy (DN) outcomes are also poorly understood.biopsy-proven DN were described, and the clinical and pathological parameters of patients with different DN outcomesSex, hematuria, and the eGFR may affect DN outcomes, whereas the glomerular classification may not.

Keywords: diabetic nephropathy     clinical characteristics     renal biopsy     outcomes    

Clinical manifestations and outcomes in severe ulcerative colitis

YANG Xuesong, YAO Wei, LIU Wenbin, LI Jun, LU Yumin

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 192-195 doi: 10.1007/s11684-007-0036-0

Abstract: In order to evaluate the clinical manifestations and outcomes of severe ulcerative colitis (UC), we retrospectively

Improving Long-term Functional Outcomes of Ischemic Stroke in the Reperfusion Era

Chuanjie Wu,Xuehong Chu,Zhanwei Zhu,Di Wu,Xunming Ji,

Engineering doi: 10.1016/j.eng.2024.04.004

Analysis of the treatment outcomes of esophageal variceal bleeding patients from multiple centers in

WANG Zhiqiang

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 171-173 doi: 10.1007/s11684-008-0031-0

Abstract: This study aimed to investigate the treatment outcomes of esophageal variceal bleeding (EVB) in China

Keywords: significant difference     predictive     medication     first-line treatment     bleeding    

Clinical outcomes of ATP-tumor chemosensitivity assay directed chemotherapy in hepatocellular carcinoma

RAO Rongsheng, CHEN Wenxue, ZHOU Xinwen, ZHOU Zheng, LI Xiaojun, ZENG Zhiping

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 157-160 doi: 10.1007/s11684-007-0029-z

Abstract: This study aims to investigate the clinical response of ATP tumor chemosensitivity assay (ATP-TCA) directed chemotherapy regimens delivered via hepatic artery infusion in 104 cases of primary liver carcinoma (PLC). Tumor tissue was obtained via laparotomy and cultivated in vitro. This tissue was put through the assay to determine chemosensitivity. A single drug regimen of either 5-FU, MMC and ADM and a combination drug regimen were used. The treatment assigned was dependent on the result of the ATP-TCA. In the control group, 30 cases of diagnosed PLC were given the conventional three-combination drug. The two groups were evaluated after three courses of chemotherapy. The results are as follows. The overall response rate of sensitivity test ranged from 36% to 44% in the single drug therapy groups and 81% in the combination drug group. The clinical overall response rate was 75% in the treatment group and 56% in control group. The treatment group had better results than the control group as survival period over six months was 80% and over one year 44%. In the control group, survival period over six months was 60% and 30% over one year. In short, ATP-TCA directed chemotherapy shows better results for terminal stages of PLC in that you can decrease the dose of drugs thereby reducing the side-effects with possible improvements in therapeutic effects.

mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 221-231 doi: 10.1007/s11684-020-0812-7

Abstract: The mammalian target of rapamycin (mTOR) critically regulates several essential biological functions, such as cell growth, metabolism, survival, and immune response by forming two important complexes, namely, mTOR complex 1 (mTORC1) and complex 2 (mTORC2). mTOR signaling is often dysregulated in cancers and has been considered an attractive cancer therapeutic target. Great efforts have been made to develop efficacious mTOR inhibitors, particularly mTOR kinase inhibitors, which suppress mTORC1 and mTORC2; however, major success has not been achieved. With the strong scientific rationale, the intriguing question is why cancers are insensitive or not responsive to mTOR-targeted cancer therapy in clinics. Beyond early findings on induced activation of PI3K/Akt, MEK/ERK, and Mnk/eIF4E survival signaling pathways that compromise the efficacy of rapalog-based cancer therapy, recent findings on the essential role of GSK3 in mediating cancer cell response to mTOR inhibitors and mTORC1 inhibition-induced upregulation of PD-L1 in cancer cells may provide some explanations. These new findings may also offer us the opportunity to rationally utilize mTOR inhibitors in cancer therapy. Further elucidation of the biology of complicated mTOR networks may bring us the hope to develop effective therapeutic strategies with mTOR inhibitors against cancer.

Keywords: mTOR     cancer therapy     resistance     GSK3     protein degradation     E3 ubiquitin ligase     PD-L1    

Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 91-95 doi: 10.1007/s11684-014-0305-7

Abstract: cancer (EOC) treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes

Keywords: ovarian carcinoma     prognostic factors     surgery     chemotherapy     survival    

Effect of antitubercular treatment on the pregnancy outcomes and prognoses of patients with genital tuberculosis

Jing Yue, Bo Zhang, Mingyue Wang, Junning Yao, Yifan Zhou, Ding Ma, Lei Jin

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 121-125 doi: 10.1007/s11684-018-0615-2

Abstract: retrospective study aims to demonstrate the effect of antitubercular treatment (ATT) on the pregnancy outcomesThe GTB recurrence rates, menstrual patterns, and pregnancy outcomes of the patients were determined

Keywords: antitubercular treatment     pregnancy     prognosis     genital tuberculosis    

Treatment outcomes of pulmonary tuberculosis in the past decade in the mainland of China: a meta-analysis

Xiangwei Li, Yu Yang, Jianmin Liu, Feng Zhou, Wei Cui, Ling Guan, Fei Shen, Cong Gao, Mufei Li, Qi Jin, Lei Gao

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 354-366 doi: 10.1007/s11684-013-0257-3

Abstract: The aim of the present study is to summarize the treatment outcomes of smear-positive pulmonary TB inAfter 2000, the summarized treatment outcomes were tending towards stability.and administrative level of the hospital were also found to influence the estimates of the treatment outcomes

Keywords: tuberculosis     treatment     outcome     China     meta-analysis    

Outcomes of haploidentical bone marrow transplantation in patients with severe aplastic anemia-II that

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 718-727 doi: 10.1007/s11684-020-0807-4

Abstract: These promising outcomes may support haplo-BMT as an alternative treatment strategy for patients with

Keywords: severe aplastic anemia     non-severe acquired aplastic anemia     haploidentical bone marrow transplantation     outcomes    

Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral

Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 86-93 doi: 10.1007/s11684-011-0118-x

Abstract: Furthermore, the neurobehavioral outcomes were significantly improved in AAV-NT-1-transduced mice compared

Keywords: adeno-associated virus     angiogenesis     gene transfer     ischemia     middle cerebral artery occlusion     netrin-1    

Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 231-239 doi: 10.1007/s11684-022-0939-9

Abstract: The primary outcome was treatment-related toxicities and adverse events; secondary outcomes were radiological

Keywords: neoadjuvant     radiotherapy     oligometastatic     prostate cancer     radical prostatectomy    

Propensity score-matched study and meta-analysis of cumulative outcomes of day 2/3 versus day 5/6 embryo

Ye Yin, Ge Chen, Kezhen Li, Qiuyue Liao, Sijia Zhang, Nieying Ma, Jing Chen, Yan Zhang, Jihui Ai

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 563-569 doi: 10.1007/s11684-017-0535-6

Abstract:

The superiority of the cumulative outcomes of day 5/6 embryo transfer to those of day 2/3 embryo transfer

Keywords: blastocyst     embryo transfer     cumulative pregnancy rate     cumulative live birth rate     IVF    

Oxidative stress in granulosa cells contributes to poor oocyte quality and IVF-ET outcomes in women with

Qiaohong Lai, Wenpei Xiang, Qing Li, Hanwang Zhang, Yufeng Li, Guijin Zhu, Chengliang Xiong, Lei Jin

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 518-524 doi: 10.1007/s11684-017-0575-y

Abstract:

The increased levels of intracellular reactive oxygen species (ROS) in granulosa cells (GCs) may affect the pregnancy results in women with polycystic ovary syndrome (PCOS). In this study, we compared thein vitro fertilization and embryo transfer (IVF-ET) results of 22 patients with PCOS and 25 patients with tubal factor infertility and detected the ROS levels in the GCs of these two groups. Results showed that the PCOS group had significantly larger follicles on the administration day for human chorionic gonadotropin than the tubal factor group (P<0.05); however, the number of retrieved oocytes was not significantly different between the two groups (P>0.05). PCOS group had slightly lower fertilization, cleavage, grade I/II embryo, clinical pregnancy, and implantation rates and higher miscarriage rate than the tubal factor group (P>0.05). We further found a significantly higher ROS level of GCs in the PCOS group than in the tubal factor group (P<0.05). The increased ROS levels in GCs caused GC apoptosis, whereas NADPH oxidase 2 (NOX2) specific inhibitors (diphenyleneiodonium and apocynin) significantly reduced the ROS production in the PCOS group. In conclusion, the increased ROS expression levels in PCOS GCs greatly induced cell apoptosis, which further affected the oocyte quality and reduced the positive IVF-ET pregnancy results of women with PCOS. NADPH oxidase pathway may be involved in the mechanism of ROS production in GCs of women with PCOS.

Keywords: PCOS     ROS     granulosa cell     IVF-ET     NADPH oxidase    

Title Author Date Type Operation

Linking elements to outcomes of knowledge transfer in the project environment: Current review and future

Journal Article

Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy

Li Zhuo, Nianrong Zhang, Guming Zou, Dapeng Chen, Wenge Li

Journal Article

Clinical manifestations and outcomes in severe ulcerative colitis

YANG Xuesong, YAO Wei, LIU Wenbin, LI Jun, LU Yumin

Journal Article

Improving Long-term Functional Outcomes of Ischemic Stroke in the Reperfusion Era

Chuanjie Wu,Xuehong Chu,Zhanwei Zhu,Di Wu,Xunming Ji,

Journal Article

Analysis of the treatment outcomes of esophageal variceal bleeding patients from multiple centers in

WANG Zhiqiang

Journal Article

Clinical outcomes of ATP-tumor chemosensitivity assay directed chemotherapy in hepatocellular carcinoma

RAO Rongsheng, CHEN Wenxue, ZHOU Xinwen, ZHOU Zheng, LI Xiaojun, ZENG Zhiping

Journal Article

mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Journal Article

Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Journal Article

Effect of antitubercular treatment on the pregnancy outcomes and prognoses of patients with genital tuberculosis

Jing Yue, Bo Zhang, Mingyue Wang, Junning Yao, Yifan Zhou, Ding Ma, Lei Jin

Journal Article

Treatment outcomes of pulmonary tuberculosis in the past decade in the mainland of China: a meta-analysis

Xiangwei Li, Yu Yang, Jianmin Liu, Feng Zhou, Wei Cui, Ling Guan, Fei Shen, Cong Gao, Mufei Li, Qi Jin, Lei Gao

Journal Article

Outcomes of haploidentical bone marrow transplantation in patients with severe aplastic anemia-II that

Journal Article

Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral

Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG

Journal Article

Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes

Journal Article

Propensity score-matched study and meta-analysis of cumulative outcomes of day 2/3 versus day 5/6 embryo

Ye Yin, Ge Chen, Kezhen Li, Qiuyue Liao, Sijia Zhang, Nieying Ma, Jing Chen, Yan Zhang, Jihui Ai

Journal Article

Oxidative stress in granulosa cells contributes to poor oocyte quality and IVF-ET outcomes in women with

Qiaohong Lai, Wenpei Xiang, Qing Li, Hanwang Zhang, Yufeng Li, Guijin Zhu, Chengliang Xiong, Lei Jin

Journal Article