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Journal Article 6

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proteome 2

CX3CR1 1

Decoction 1

Decoction intervention 1

Dedifferentiation 1

Hippo signaling pathway 1

N6-methyladenosine 1

PEPT1 1

Phosphoproteome 1

Primary hepatocytes 1

Proteome 1

TPM2 1

Ubiquitination 1

acupuncture 1

amyotrophic lateral sclerosis 1

colorectal cancer 1

epi-transcriptome 1

fMRI 1

glutathione peroxidase 1

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Effects of Decoction on plasma proteome in cirrhosis: preliminary experimental study with rats

LIU Jie, WANG Jiyao, WEI Liming, LU Ye, Jin Hong

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 39-44 doi: 10.1007/s11684-008-0008-z

Abstract: The aim of this paper is to study the effects of Decoction on the plasma proteome in cirrhotic rats.

Keywords: Decoction intervention     serine/threonine-protein     underwent     Decoction     glutathione peroxidase    

Proteome comparisons reveal influence of different dietary proteins on the development of rat jejunum

Mengjie LI, Chunbao LI, Shangxin SONG, Xinglian XU, Guanghong ZHOU

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 362-372 doi: 10.15302/J-FASE-2018206

Abstract:

This study compared proteome profiles and morphological changes of rat jejunum in response to differentProteome analysis, histological observation and PEPT1 quantification of the jejunum were performed.

Keywords: Hippo signaling pathway     meat protein     PEPT1     proteome analysis     rat jejunum    

iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnostic

Yiming Ma,Ting Xiao,Quan Xu,Xinxin Shao,Hongying Wang

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 278-285 doi: 10.1007/s11684-016-0453-z

Abstract:

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. We aimed to find novel molecules as potential biomarkers for the early diagnosis of CRC. A serum-free conditioned medium was successfully collected from three pairs of CRC tissue and adjacent normal tissue. iTRAQ-based quantitative proteomic analysis was applied to compare the differences in secretome between primary CRC mucosa and adjacent normal mucosa. A total of 145 kinds of proteins were identified. Of these proteins, 29 were significantly different between CRC and normal tissue. Tropomyosin 2 β (TPM2) exhibited the most significant differences; as such, this protein was selected for further validation. Quantitative real-time PCR indicated that the mRNA expression of TPM2 significantly decreased in the CRC tissue compared with the paired adjacent normal tissue. Immunohistochemical analysis also confirmed that TPM2 was barely detected at protein levels in the CRC tissue. In summary, this study revealed potential molecules for future biomarker applications and provided an efficient approach for the differential analysis of cancer-associated secretome. TPM2 may be valuable for the early diagnosis of CRC.

Keywords: iTRAQ     secretome     colorectal cancer     TPM2    

Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics

Frontiers of Medicine 2023, Volume 17, Issue 5,   Pages 993-1005 doi: 10.1007/s11684-023-0989-7

Abstract: Migraine is one of the most prevalent and disabling neurological disease, but the current pharmacotherapies show limited efficacy and often accompanied by adverse effects. Acupuncture is a promising complementary therapy, but further clinical evidence is needed. The influence of acupuncture on migraine is not an immediate effect, and its mechanism remains unclear. This study aims to provide further clinical evidence for the anti-migraine effects of acupuncture and explore the mechanism involved. A randomized controlled trial was performed among 10 normal controls and 38 migraineurs. The migraineurs were divided into blank control, sham acupuncture, and acupuncture groups. Patients were subjected to two courses of treatment, and each treatment lasted for 5 days, with an interval of 1 day between the two courses. The effectiveness of treatment was evaluated using pain questionnaire. The functional magnetic resonance imaging (fMRI) data were analyzed for investigating brain changes induced by treatments. Blood plasma was collected for metabolomics and proteomics studies. Correlation and mediation analyses were performed to investigate the interaction between clinical, fMRI and omics changes. Results showed that acupuncture effectively relieved migraine symptoms in a way different from sham acupuncture in terms of curative effect, affected brain regions, and signaling pathways. The anti-migraine mechanism involves a complex network related to the regulation of the response to hypoxic stress, reversal of brain energy imbalance, and regulation of inflammation. The brain regions of migraineurs affected by acupuncture include the lingual gyrus, default mode network, and cerebellum. The effect of acupuncture on patients’ metabolites/proteins may precede that of the brain.

Keywords: acupuncture     migraine     fMRI     metabolome     proteome    

Dysregulated N-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis

Frontiers of Medicine 2024, Volume 18, Issue 2,   Pages 285-302 doi: 10.1007/s11684-023-1035-5

Abstract: chromatography–mass spectrometry were utilized for m6A profiling in peripheral immune cells and serum proteomeSerum proteome analysis demonstrated the role of dysregulated immune cell migration in ALS.

Keywords: amyotrophic lateral sclerosis     N6-methyladenosine     epi-transcriptome     proteome     single cell    

Temporal Integrative Omics Reveals an Increase in Nondegradative Ubiquitylation during Primary Hepatocyte Dedifferentiation Article

Zhengyi Jiang, Zeyu Sun, Xiaoxi Ouyang, Yalei Zhao, Menghao Zhou, Baohong Wang, Qirui Li, Linxiao Fan, Sainan Zhang, Lanjuan Li

Engineering 2020, Volume 6, Issue 11,   Pages 1302-1314 doi: 10.1016/j.eng.2020.02.011

Abstract: While the transcriptional regulation and whole cell proteome (WCP) of PHCs have been extensively studiedTaken together, our data provide new insights into proteome dynamics during PHC dedifferentiation and

Keywords: Ubiquitination     Phosphoproteome     Proteome     Dedifferentiation     Primary hepatocytes    

Title Author Date Type Operation

Effects of Decoction on plasma proteome in cirrhosis: preliminary experimental study with rats

LIU Jie, WANG Jiyao, WEI Liming, LU Ye, Jin Hong

Journal Article

Proteome comparisons reveal influence of different dietary proteins on the development of rat jejunum

Mengjie LI, Chunbao LI, Shangxin SONG, Xinglian XU, Guanghong ZHOU

Journal Article

iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnostic

Yiming Ma,Ting Xiao,Quan Xu,Xinxin Shao,Hongying Wang

Journal Article

Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics

Journal Article

Dysregulated N-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis

Journal Article

Temporal Integrative Omics Reveals an Increase in Nondegradative Ubiquitylation during Primary Hepatocyte Dedifferentiation

Zhengyi Jiang, Zeyu Sun, Xiaoxi Ouyang, Yalei Zhao, Menghao Zhou, Baohong Wang, Qirui Li, Linxiao Fan, Sainan Zhang, Lanjuan Li

Journal Article