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Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

Chuanfeng Wu, Cynthia E. Dunbar

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 356-371 doi: 10.1007/s11684-011-0159-1

Abstract: Virus-based vectors are widely used in hematopoietic stem cell (HSC) gene therapy, and have the abilityTo date, HSC gene therapy has been successfully employed in the clinic for improving clinical outcomesHowever, adverse events were observed during some of these HSC gene therapy clinical trials, linked tobasis of vector-mediated genotoxicity, with the aim of developing safer vectors and lower-risk gene therapyreview will summarize current information on the mechanisms of insertional mutagenesis in hematopoietic stem

Keywords: gene therapy     hematopoietic stem cells     insertional mutagenesis     genotoxicity     induced pluripotent stem cell    

Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 827-858 doi: 10.1007/s11684-022-0948-8

Abstract: Besides routine therapeutic methods, stem cells are rapidly being examined as viable alternative therapiesRemarkable progress has been made in understanding the biology and purpose of stem cells.The affected pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) are further studied forthis study discusses current developments in the use of some kinds of MSCs such as adipose-derived stembeen used to manage ovarian and uterine disorders, and each technique presents a novel method for the therapy

Keywords: infertility     stem cell therapy     mesenchymal stem cells     pluripotent stem cells    

The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 190-200 doi: 10.1007/s11684-014-0323-5

Abstract:

Over the past few years, several new achievements have been made from stem cell studies, many of whichMoreover, some stem cell-based products have been approved for marketing by different national regulatoryHowever, many critical issues associated mainly with incomplete understanding of stem cell biology andcell regulatory sciences with a goal of promoting the steadfast growth of the well-regulated stem celltherapies abreast of evolvement of stem cell sciences and technologies.

Keywords: stem cell-based medicinal products (SCMPs)     stem cell therapy (SCT)     safety     effectiveness     standards     guidelines    

Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated

Hang Xiang,Xiaomei Zhang,Chao Yang,Wenhuan Xu,Xin Ge,Rong Zhang,Ya Qiu,Wanjun Sun,Fan Li,Tianyuan Xiang,Haixu Chen,Zheng Wang,Qiang Zeng

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 522-526 doi: 10.1007/s11684-016-0485-4

Abstract:

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with continuous or recurrent symptoms. A 42-year-old male patient with intermittent diarrhea accompanied by bloody mucopurulent stools was admitted to our hospital. The diagnosis of UC was confirmed by a combination of laboratory examination, colonoscopy, and histological assay. The patient developed herpes zoster in the hospital, which challenged traditional treatments. Therefore, we performed an autologous bone marrow cells to modulate the immune system with his permission. Autologous bone marrow mononuclear cells were collected and injected locally into the bowel mucosa, and subsequently injected systemically through a peripheral vein. After the patient underwent auto bone marrow mononuclear cells transplantations twice, the patient’s symptoms were alleviated. Furthermore, he recovered from hematochezia, and his hypersensitive C reactive protein decreased. Colonoscopy results showed reduced lesions and decreased areas with bleeding and edema in the sigmoid colon and rectum. No recurrence occurred in the subsequent two years, but long-time monitoring is still necessary for the prophylaxis of colorectal cancer.

Keywords: autograft     bone marrow stem cells     ulcerative colitis     cell therapy    

EBV-associated lymphoproliferative disease post-CAR-T cell therapy

Frontiers of Medicine 2024, Volume 18, Issue 2,   Pages 394-398 doi: 10.1007/s11684-023-1032-8

Abstract: ) are common complications that occur after solid organ transplantation or allogeneic hematopoietic stem-cellHowever, their occurrence and treatment post-chimeric antigen receptor-modified T (CAR-T) cell therapyAfter receiving CAR-T cell therapy in tandem with autologous HSCT, the patients achieved complete remissionHowever, with a median time of 38.5 months after CAR-T cell therapy, B-cell-derived EBV-LPDs were diagnosedby immune normalization strategy or B-cell depleting therapy.

Keywords: EBV-associated lymphoproliferative disease     chimeric antigen receptor T-cell     autologous stem cell transplantation    

The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 348-355 doi: 10.1007/s11684-011-0150-x

Abstract: Research into the biological properties and clinical potential of stem cells has spurred strong publicof demonstrated safety and efficacy have been developed with the exception of uses of hematopoietic stembasis notwithstanding, hundreds of companies and private clinics around the world now sell putative stemcell treatments for an enormously broad range of medical and quality-of-life conditions.In this review, I provide an overview of the global industry in pseudomedical stem cell treatments, with

Keywords: stem cell tourism     medical ethics     stem cell policy and regulation     alternative medicine    

Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression

Frontiers of Medicine 2024, Volume 18, Issue 3,   Pages 430-445 doi: 10.1007/s11684-023-1049-z

Abstract: A tumor subpopulation called liver cancer stem cells (CSCs) significantly accounts for the initiation

Keywords: liver cancer     cancer stem cell     immune cell     immunotherapy    

Therapeutic potential of stem cell in liver regeneration

Jinzheng LI, Min LI, Bolin NIU, Jianping GONG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 26-32 doi: 10.1007/s11684-011-0107-0

Abstract: Stem cell therapy, with the ability for self-renewal and potential for multilineage differentiation,cells derived from multipotent stem cells leads to donor cell-mediated repopulation of the liver andHowever, a registered clinical application based on stem cell technology will take at least an additional5 to 10 years because of some limitations; e.g. the lack of suitable cell sources and risk of teratomaThis review summarizes the general understanding of the therapeutic potentials of stem cells in liver

Keywords: stem cell     liver disease     regenerative medicine    

Stem cell niches and endogenous electric fields in tissue repair

Li LI, Jianxin JIANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 40-44 doi: 10.1007/s11684-011-0108-z

Abstract:

Adult stem cells are responsible for homeostasis and repair of many tissues.Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, whichMany regulatory factors are involved in the stem cell-based repair process, including stem cell nichesHere we briefly review the role of stem cell niches and endogenous electric fields in tissue repair,and hypothesize that endogenous electric fields become part of stem cell niche in the wound site.

Keywords: stem cell     stem cell niche     electric field     tissue repair    

Transcriptomics and proteomics in stem cell research

Hai Wang,Qian Zhang,Xiangdong Fang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 433-444 doi: 10.1007/s11684-014-0336-0

Abstract:

Stem cells are capable of self-renewal and differentiation, and the processes regulating these eventsIn particular, the molecular mechanisms of the self-renewal, proliferation, and differentiation of stemcell biology.and proteomic characterization of the different stem cell processes.cell biology and promote the clinical applications of stem cells.

Keywords: embryonic stem cells     transcriptomics     proteomics    

Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 227-239 doi: 10.1007/s11684-021-0896-8

Abstract: Chronic stress impairs radial neural stem cell (rNSC) differentiation and adult hippocampal neurogenesis

Keywords: cannabidiol     depression     radial neural stem cells     neurogenesis    

Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

Xiaodong Mo, Xiaojun Huang

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 306-315 doi: 10.1007/s11684-013-0279-x

Abstract:

Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective options forSeveral protocols (with or without ex vivo T-cell depletion (TCD)) have been established worldwide

Keywords: partially matched related donor     hematopoietic stem cell transplantation     allogeneic    

In vivo imaging of hematopoietic stem cell development in the zebrafish

Panpan Zhang, Feng Liu

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 239-247 doi: 10.1007/s11684-011-0123-0

Abstract: imaging is crucial for developmental biology and can further help to follow cell development/differentiationhas facilitated tracing of the developmental dynamics of a specific organ, tissue, or even a single cellhematopoiesis due to its transparent embryo at early stage; moreover, different zebrafish hematopoietic stem

Keywords: hematopoietic stem cell     hematopoiesis     in vivo imaging     transgenics     zebrafish    

Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 412-420 doi: 10.1007/s11684-015-0423-x

Abstract: mutations provides the first proof-of-principle investigation on the identification of preleukemic stemAlthough DNMT3A mutations alone may only transform hematopoietic stem cells into pre-LSCs without causing

Keywords: preleukemic stem cell     acute myeloid leukemia     relapse     DNMT3A    

The stem cell and tissue engineering research in Chinese ophthalmology

GE Jian, LIU Jingbo

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 6-10 doi: 10.1007/s11684-007-0002-x

Abstract: Much has been considerably developed recently in the ophthalmic research of stem cell (SC) and tissue

Keywords: available     observable     neuroregeneration     protection     function reconstruction    

Title Author Date Type Operation

Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

Chuanfeng Wu, Cynthia E. Dunbar

Journal Article

Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism

Journal Article

The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Journal Article

Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated

Hang Xiang,Xiaomei Zhang,Chao Yang,Wenhuan Xu,Xin Ge,Rong Zhang,Ya Qiu,Wanjun Sun,Fan Li,Tianyuan Xiang,Haixu Chen,Zheng Wang,Qiang Zeng

Journal Article

EBV-associated lymphoproliferative disease post-CAR-T cell therapy

Journal Article

The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Journal Article

Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression

Journal Article

Therapeutic potential of stem cell in liver regeneration

Jinzheng LI, Min LI, Bolin NIU, Jianping GONG

Journal Article

Stem cell niches and endogenous electric fields in tissue repair

Li LI, Jianxin JIANG

Journal Article

Transcriptomics and proteomics in stem cell research

Hai Wang,Qian Zhang,Xiangdong Fang

Journal Article

Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation

Journal Article

Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

Xiaodong Mo, Xiaojun Huang

Journal Article

In vivo imaging of hematopoietic stem cell development in the zebrafish

Panpan Zhang, Feng Liu

Journal Article

Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Journal Article

The stem cell and tissue engineering research in Chinese ophthalmology

GE Jian, LIU Jingbo

Journal Article