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Journal Article 8

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2024 1

2021 2

2011 1

2009 1

2008 1

2000 1

Keywords

ATM 1

ATM research and development 1

ATM solution 1

Air traffic management (ATM) 1

BEND4 1

DNA damage 1

DNA methylation 1

DNA-PK(cs)-binding protein 1

DNMT1 1

Deployment 1

IRF7 1

JAK2V617F detection 1

JAK2V617F-positive 1

Ku80 1

NHEJ pathway 1

SESAR 1

Single European Sky 1

Single-tube bi-directional 1

antimicrobial proteins / antiviral profiling of bacteriocins / antiviral therapeutics / immunomodulation / nanosensor technology / mutated SARS-CoV-2 1

ataxia telangiectasia mutated protein 1

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Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 179-187 doi: 10.1007/s11705-009-0268-4

Abstract: Ataxia-telangiectasia mutated (ATM) plays a key role in regulating the cellular response to ionizingThe tumor-suppressor gene ATM, mutations in which cause the human genetic disease ataxia telangiectasiaActivation of ATM results in phosphorylation of many downstream targets that modulate numerous damageand its signaling pathways, explore whether DNA double-strand breaks are the sole activators of ATMto ATM and its function.

Keywords： ataxia-telangiectasia mutated (ATM)     cell cycle checkpoint     DNA damage     signalling transduction    

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Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity of tumor cells

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 26-29 doi: 10.1007/s11684-009-0008-7

Abstract: Ku80, DNA-PK catalytic subunit (DNA-PKcs) and ataxia telangiectasia mutated (ATM) proteins are majorclone formation assay, and western blot was applied to detect the expressions of Ku80, DNA-PKcs and ATMpositive correlativity between the expression of DNA-PKcs and SF2 ( ＝0.723, = 0.043), but Ku80 and ATM

Keywords： Ku80     DNA-PK(cs)-binding protein     human     ataxia telangiectasia mutated protein     tumor cell lines     radiosensitivity    

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China's First ATM Switching System and its Networking

Lei Zhenming

Strategic Study of CAE 2000, Volume 2, Issue 2,   Pages 53-55

Abstract:

The design and implementation of the first ATM Switching system of China (Named BTC -9500) was started

The research on the BTC - 9500 networking unveiled the disadvantage of ATM switch/IP routerThe scheme of switching both ATM cells and IP datagram within a single switching fabric was proposed

Keywords： telecommunications     switching     ATM    

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ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2: A SYSTEMATIC

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4,   Pages 603-622 doi: 10.15302/J-FASE -2021397

Abstract:

The COVID-19 infections caused by SARS-CoV-2 have resulted in millions of people being infected and thousands of deaths globally since November 2019. To date, no unique therapeutic agent has been developed to slow the progression of this pandemic. Despite possessing antiviral traits the potential of bacteriocins to combat SARS-CoV-2 infection has not been fully investigated. This review summarizes the mechanisms by which bacteriocins can be manipulated and implemented as effective virus entry blockers with infection suppression potential properties to highly transmissible viruses through comprehensive immune modulations that are potentially effective against COVID-19. These antimicrobial peptides have been suggested as effective antiviral therapeutics and therapeutic supplements to prevent rapid virus transmission. This review also provides a new insight into the cellular and molecular alterations which have made SARS-CoV-2 self-modified with diversified infection patterns. In addition, the possible applications of antimicrobial peptides through both natural and induced mechanisms in infection prevention perspectives on changeable virulence cases are comprehensively analyzed. Specific attention is given to the antiviral mechanisms of the molecules along with their integrative use with synthetic biology and nanosensor technology for rapid detection. Novel bacteriocin based therapeutics with cutting-edge technologies might be potential substitutes for existing time-consuming and expensive approaches to fight this newly emerged global threat.

 

Keywords： antiviral profiling of bacteriocins / antiviral therapeutics / immunomodulation / nanosensor technology / mutated    

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SESAR: The Past, Present, and Future of European Air Traffic Management Research Perspective

Tatjana Bolić, Paul Ravenhill

Engineering 2021, Volume 7, Issue 4,   Pages 448-451 doi: 10.1016/j.eng.2020.08.023

Abstract:

The Single European Sky ATM Research (SESAR) project is the technological pillar of the European Commission’s Single European Sky Initiative to modernize air traffic management (ATM).Undertaking; the deployment part, which is managed by the SESAR Deployment Manager; and the European ATMThe latest European ATM Master Plan was adopted just prior to the current pandemic.

Keywords： SESAR     Air traffic management (ATM)     Single European Sky     ATM research and development     ATM solution    

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Epigenetic silencing of BEND4, a novel DNA damage repair gene, is a synthetic lethal marker for ATM inhibitor

Frontiers of Medicine doi: 10.1007/s11684-023-1053-3

Abstract: Loss of BEND4 increased the sensitivity of PDAC cells to ATM inhibitor.BEND4 and indicated that methylation of BEND4 may serve as a potential synthetic lethal marker for ATM

Keywords： BEND4     DNA methylation     synthetic lethality     NHEJ pathway    

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine 2024, Volume 18, Issue 2,   Pages 357-374 doi: 10.1007/s11684-023-1016-8

Abstract: p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved.immune responses featuring the striking upregulation of the innate immune player IRF7 in the p53-mutatedOur integrative studies reveal the potential of repurposing decitabine for the treatment of p53-mutated

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

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Observation of a higher JAK2 V617F homozygous mutated clone in polycythemia vera compared to essential

LIU Hongxing, TONG Chunrong, CAI Peng, GU Jiangying, LIN Yuehui, TENG Wen, WANG He, ZHANG Ying, ZHU Ping

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 309-313 doi: 10.1007/s11684-008-0059-1

Abstract: Single-tube bi-directional allele specific amplification (SB-ASA) and real-time quantitative polymerase chain reaction (RQ-PCR) assays were developed and performed for JAK2V617F detection on 40 polycythemia vera (PV) samples, 31 essential thrombocythemia (ET) samples, 40 acute leukemia samples, and 40 healthy control samples. Differences between detect limitations of the two assays and their influence on the mutation detection rate were analyzed. The results showed that in some samples, the JAK2V617F burden was as low as nearly 1%, and thus more JAK2V617F-positive samples were detected by RQ-PCR than by SB-ASA assay due to the former higher detect limitation. Mutation allele ratios in PV and ET samples and their relevance to biological characteristics were also analyzed. The results showed that the mutation allele ratio was 0.436 ± 0.261 in PV, higher than the 0.216 ± 0.207 in ET; percentage of certainly homozygous mutation carriers in PV was 40.54%, higher than the 10% in ET. However, statistical analysis showed no relevance between mutation allele burden and sex or age. Our result shows that the pathogenesis of PV and ET may be related to the mutation allele burden of JAK2V617F.

Keywords： specific amplification     essential thrombocythemia     Single-tube bi-directional     JAK2V617F-positive     JAK2V617F detection    

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Title Author Date Type Operation

Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Journal Article

Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity of tumor cells

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Journal Article

China's First ATM Switching System and its Networking

Lei Zhenming

Journal Article

ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2: A SYSTEMATIC

Journal Article

SESAR: The Past, Present, and Future of European Air Traffic Management Research

Tatjana Bolić, Paul Ravenhill

Journal Article

Epigenetic silencing of BEND4, a novel DNA damage repair gene, is a synthetic lethal marker for ATM inhibitor

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Journal Article

Observation of a higher JAK2 V617F homozygous mutated clone in polycythemia vera compared to essential

LIU Hongxing, TONG Chunrong, CAI Peng, GU Jiangying, LIN Yuehui, TENG Wen, WANG He, ZHANG Ying, ZHU Ping

Journal Article