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Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 179-187 doi: 10.1007/s11705-009-0268-4

Abstract: phosphorylation of many downstream targets that modulate numerous damage response pathways, most notably cellcycle checkpoints.

Keywords： ataxia-telangiectasia mutated (ATM)     cell cycle checkpoint     DNA damage     signalling transduction    

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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: In particular, Siglec10 was upregulated in patients with kidney renal clear cell carcinoma (KIRC

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

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Analysis on carbon emission reduction intensity of fuel cell vehicles from a life-cycle perspective

Frontiers in Energy 2024, Volume 18, Issue 1,   Pages 16-27 doi: 10.1007/s11708-023-0909-1

Abstract: The hydrogen fuel cell vehicle is rapidly developing in China for carbon reduction and neutrality.This paper evaluated the life-cycle cost and carbon emission of hydrogen energy via lots of field surveysThe result indicates that hydrogen fuel cell vehicle (FCV) has the best environmental performance but

Keywords： hydrogen energy     life-cycle assessment (LCA)     fuel cell vehicle     carbon emission     energy cost    

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Discovery of small molecule degraders for modulating cell cycle

Frontiers of Medicine 2023, Volume 17, Issue 5,   Pages 823-854 doi: 10.1007/s11684-023-1027-5

Abstract: The cell cycle is a complex process that involves DNA replication, protein expression, and cell divisionDysregulation of the cell cycle is associated with various diseases.Cyclin-dependent kinases (CDKs) and their corresponding cyclins are major proteins that regulate the cellcycle.

Keywords： PROTAC     molecular glue     degrader     cell cycle     CDK     cyclin    

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Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 18-42 doi: 10.1007/s11684-022-0976-4

Abstract: With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expandingFurthermore, the therapeutic role of immune-checkpoint inhibitors (ICIs) in oncogene-driven NSCLC remains

Keywords： non-small cell lung cancer     driver mutations     treatment strategy     resistant mechanism     immune-checkpoint    

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EBV-associated lymphoproliferative disease post-CAR-T cell therapy

Frontiers of Medicine 2024, Volume 18, Issue 2,   Pages 394-398 doi: 10.1007/s11684-023-1032-8

Abstract: common complications that occur after solid organ transplantation or allogeneic hematopoietic stem-cellHowever, their occurrence and treatment post-chimeric antigen receptor-modified T (CAR-T) cell therapyTwo patients had been diagnosed with EBV-positive aggressive B-cell lymphoma and experienced relapsesHowever, with a median time of 38.5 months after CAR-T cell therapy, B-cell-derived EBV-LPDs were diagnosed, and they were relieved through the administration of immune checkpoint inhibitor or B-cell-depleting

Keywords： EBV-associated lymphoproliferative disease     chimeric antigen receptor T-cell     autologous stem cell transplantation     immune checkpoint inhibitor    

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Immunometabolism: a new dimension in immunotherapy resistance

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 585-616 doi: 10.1007/s11684-023-1012-z

Abstract: Immune checkpoint inhibitors (ICIs) have demonstrated unparalleled clinical responses and revolutionizedCorrespondingly, people used to pay more attention to the effect of tumor cell metabolism on immunocytes

Keywords： immune cell     immunometabolism     metabolic reprogramming     immunotherapy     resistance     tumor microenvironment     immune checkpoint inhibitor    

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Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 440-450 doi: tzg@ustc.edu.cn

Abstract: Various cellular sources, including peripheral blood mononuclear cells (PBMCs), stem cells, and NK cellHowever, considering the safety, activities, and reliability of the cell products, researchers must developIn this review, the challenges on NK cell-based therapeutic approaches and clinical outcomes are discussed

Keywords： natural killer cells     immunotherapy     adoptive transfer     genetic modification     immune checkpoint inhibitor    

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The role of CDK1 siRNA interference in cell cycle and cell apoptosis

Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 384-389 doi: 10.1007/s11684-009-0070-1

Abstract: CDK1) siRNA was transfected into cells to silence the CDK1 gene expression and study its role in the cellcycle and cell apoptosis.The cell cycle was analyzed by using DNA content analysis by flow cytometry.Cell apoptosis was detected by the Annexin V/PI method.The decreased CDK1 expression by siRNA silencing gave rise to cell cycle arrest in G/M phase but did

Keywords： cyclin-dependent kinase1     siRNA interference     cell cycle     apoptosis    

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Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cell

SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 359-363 doi: 10.1007/s11684-007-0069-4

Abstract: cycle control of the lung cancer cell line A549.Cell proliferation was assessed by cell counting kit-8 (CCK-8).Cell cycle control and apoptosis were analyzed by flow cytometry.in reduced tumor cell growth via the inhibition of cell proliferation, the activation of apoptosis andthe interruption of cell cycle transition.

Keywords： control     interruption     cytoplasm     number     growth    

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Effects of galectin-3 inhibition on endometrial cell cycle and adhesion

LEI Caixia, ZHANG Wei, SUN Xiaowei, DU Guoping, WANG Li, LIU Yinkun

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 390-397 doi: 10.1007/s11684-007-0076-5

Abstract: Galectin-3 (gal-3) and its ligands have been implicated in cell transformation and cancer metastasis.protein has been found in uterine epithelial cells adjacent to implanting blastocysts in different cellin the establishment of human endometrial receptivity, the expression of gal-3 in human endometrial cellAfter the suppression of gal-3, cell cycle changes and the expression of integrin 1 were detected by
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Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 24-31 doi: 10.1007/s11684-019-0679-7

Abstract: Immune checkpoint inhibitors are a promising strategy in the treatment of cancer, especially advancedHowever, not all patients are responsive to immune checkpoint inhibitors.rate depends on the immune microenvironment, tumor mutational burden (TMB), expression level of immune checkpointlarge volumes of data, which allow researchers to explore responsive or resistant biomarkers of immune checkpointintroduced some methodologies on database selection, biomarker screening, current progress of immune checkpoint

Keywords： immune checkpoint blockade     sensitivity     resistance     data mining    

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Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 307-321 doi: 10.1007/s11684-022-0927-0

Abstract: The discovery of immune checkpoint inhibitors, such as PD-1/PD-L1 and CTLA-4, has played an importantAntibiotics are widely applied in clinical treatment, and they are inevitably used in combination with immune checkpointClinical practice has revealed that antibiotics can weaken the therapeutic response to immune checkpointStudies have shown that the gut microbiota is essential for the interaction between immune checkpointThis review focuses on the interactions between immune checkpoint inhibitors and antibiotics, with an

Keywords： tumor immunotherapy     immune checkpoint inhibitor     antibiotics     gut microbiota     drug–drug interaction    

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Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 32-44 doi: 10.1007/s11684-018-0678-0

Abstract: In particular, immune checkpoint inhibitors are proved to be unprecedentedly in increasing the overallsurvival rates of patients with refractory cancers, such as advanced melanoma, non-small cell lung cancer, and renal cell carcinoma.Therefore, doctors urgently need reliable predictive biomarkers for checkpoint inhibitor therapies toHere, we review the biomarkers that can serve as potential predictors of the outcomes of immune checkpoint

Keywords： immune checkpoint     companion diagnosis     PD-L1     tumor mutation burden     immune score    

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract: Keytruda for treatment of several types of malignancies, such as metastatic melanoma, metastatic non-small-cell

Keywords： molecular classification     precision medicine     pembrolizumab     PD-1/PD-L1     MSI-H    

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Title Author Date Type Operation

Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

Analysis on carbon emission reduction intensity of fuel cell vehicles from a life-cycle perspective

Journal Article

Discovery of small molecule degraders for modulating cell cycle

Journal Article

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Journal Article

EBV-associated lymphoproliferative disease post-CAR-T cell therapy

Journal Article

Immunometabolism: a new dimension in immunotherapy resistance

Journal Article

Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Journal Article

The role of CDK1 siRNA interference in cell cycle and cell apoptosis

Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,

Journal Article

Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cell

SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping

Journal Article

Effects of galectin-3 inhibition on endometrial cell cycle and adhesion

LEI Caixia, ZHANG Wei, SUN Xiaowei, DU Guoping, WANG Li, LIU Yinkun

Journal Article

Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

Journal Article

Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

Journal Article

Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

Journal Article

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Journal Article