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Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue cultures

Jian Jiao, Na Meng, Hong Wang, Luo Zhang

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 486-491 doi: 10.1007/s11684-013-0287-x

Abstract: Basal and ATP-stimulated ciliary beat frequency (CBF) was measured using a high-speed digital microscopicThese two cultures demonstrated similar ciliary beat frequency values at baseline (7.78±1.99 Hzgrowing well-differentiated nasal ciliated and non-ciliated cells, which have growth characteristics and ciliary

Keywords: ciliated cells     ciliary beat frequency     dissociated tissue culture     explant culture     nasal epithelial cells    

Case report of neurofibromatosis type 1 combined with primary ciliary dyskinesia

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 933-937 doi: 10.1007/s11684-021-0860-7

Abstract: early-onset wet cough, sinusitis, and sperm quality decline, we considered the possibility of primary ciliary

Keywords: primary ciliary dyskinesia     neurofibromatosis     bronchiectasis     transmission electron microscopy     genetic    

Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients

Frontiers of Medicine 2023, Volume 17, Issue 6,   Pages 1236-1249 doi: 10.1007/s11684-023-0997-7

Abstract: Primary ciliary dyskinesia (PCD) is a highly heterogeneous recessive inherited disorder.

Keywords: primary ciliary dyskinesia     CFAP54     cilia    

Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Frontiers of Medicine 2023, Volume 17, Issue 5,   Pages 957-971 doi: 10.1007/s11684-023-0988-8

Abstract: Primary ciliary dyskinesia (PCD) is a congenital, motile ciliopathy with pleiotropic symptoms.

Keywords: DNAH10     mice     motile cilia     mutation     primary ciliary dyskinesia    

Solid-state transformer-based new traction drive system and control

Jianghua FENG, Jing SHANG, Zhixue ZHANG, Huadong LIU, Zihao HUANG

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 3,   Pages 411-426 doi: 10.1007/s11465-018-0467-0

Abstract: an efficient SSTT optimized topology combining high-voltage cascaded rectifiers with high-power high-frequencymathematical model of secondary power transfer is built, and the mechanism of pulsating voltage resulting in beatfrequency of LLC resonant converter is revealed, so as to design optimum matching of system parameters

Keywords: synchronous rotating reference frame     carrier-interleaving phase shift control     secondary pulsating voltage     beatfrequency    

Improved three-vector based dead-beat model predictive direct power control strategy for grid-connected None

Chen-wen CHENG, Heng NIAN, Long-qi LI

Frontiers of Information Technology & Electronic Engineering 2018, Volume 19, Issue 11,   Pages 1420-1431 doi: 10.1631/FITEE.1601874

Abstract: Moreover, a high sampling frequency is needed to ensure satisfactory steady-state performance, whichTo solve these problems, a novel dead-beat MPDPC strategy is proposed, using two active inverter voltageAdoption of three inverter vectors ensures a constant switching frequency.experiments based on a 1 kW inverter setup validate the feasibility of the proposed three-vector based dead-beat

Keywords: Grid-connected inverter     Model predictive control     Direct power control     Three vectors     Constant switching frequency    

A frequency error estimation for isogeometric analysis of Kirchhoff–Love cylindrical shells

Frontiers of Structural and Civil Engineering 2023, Volume 17, Issue 10,   Pages 1599-1610 doi: 10.1007/s11709-023-0006-x

Abstract: A frequency error estimation is presented for the isogeometric free vibration analysis of Kirchhoff–LoveBy analyzing the discrete isogeometric equations with the aid of harmonic wave assumption, the frequencyIn particular, the governing relationship of the continuum frequency for Kirchhoff–Love cylindrical shellsis naturally embedded into the frequency error measures without the need of explicit frequency expressionsNumerical results not only thoroughly verify the theoretical convergence rates of frequency solutions

Keywords: isogeometric analysis     Kirchhoff–Love cylindrical shell     free vibration     frequency error     convergence    

Capacity limitation of nuclear units in grid based on analysis of frequency regulation

Yiping DAI, Pan JIANG, Lin GAO, Weimin KAN, Xiaoqing XIAO, Ge JIN

Frontiers in Energy 2012, Volume 6, Issue 2,   Pages 148-154 doi: 10.1007/s11708-012-0174-1

Abstract: Based on the analysis of frequency regulation, mathematic models for nuclear units in the grid are establishedThe relationship between different styles of frequency regulation and the allowable capacity of the nuclear

Keywords: nuclear units capacity     overspeed     primary frequency control (PFC)     second frequency control (SFC)    

Experimental study of structural damage identification based on modal parameters and decay ratio of acceleration signals

Zhigen WU, Guohua LIU, Zihua ZHANG

Frontiers of Structural and Civil Engineering 2011, Volume 5, Issue 1,   Pages 112-120 doi: 10.1007/s11709-010-0069-3

Abstract: Preliminary analysis was developed considering the beat phenomenon in the nonlinear state to explain

Keywords: ratio of acceleration signals (DRAS)     wavelet transform (WT)     modal analysis     reinforced concrete beam     beat    

Calculation of collision frequency function for aerosol particles in free molecule regime in presence

Xiaowei LUO, Yannick BENICHOU, Suyuan YU

Frontiers in Energy 2013, Volume 7, Issue 4,   Pages 506-510 doi: 10.1007/s11708-013-0275-5

Abstract: The collision frequency function for aerosol particles has already been calculated for the free moleculeforce, electric force and molecular forces, created by particles themselves, recalculated the collision frequencyAttractive forces increase naturally the collision frequency, while repulsive forces decrease it.

Keywords: aerosol particles     collision frequency function     coagulation    

Parameter identification of interconnected power system frequency after trip-out of high voltage transmission

Xuzhan ZHOU,Shanshan LIU,Mingkun WANG,Yiping DAI,Yaohua TANG

Frontiers in Energy 2014, Volume 8, Issue 3,   Pages 386-393 doi: 10.1007/s11708-014-0323-9

Abstract: Accurate modeling and parameters of high voltage (HV) grid are critical for stability research of system frequencyIn this paper, simulation modeling of the system frequency was conducted of an interconnected power system

Keywords: high voltage (HV) grid     frequency stability parameter identification     primary frequency regulation (PFR    

Fuel variability effect on flickering frequency of diffusion flames

Jizhao LI, Yang ZHANG

Frontiers in Energy 2009, Volume 3, Issue 2,   Pages 134-140 doi: 10.1007/s11708-009-0034-9

Abstract: The intent of this study is to investigate the fuel variability on the flickering frequency of diffusionIt was found that the low frequency oscillation of flow and flame structures depended only weakly onWhen a mixture of methane/propane at a ratio of 1:1 was used the peak flickering frequency was aroundMechanisms thought to produce changes in the dynamic response and frequency harmonics were discussed.

Keywords: fuel variability     flickering frequency     diffusion flames     dynamics of combustion    

Oscillation frequency of simplified arterial tubes

Hui AN, Fan HE, Lingxia XING, Xiaoyang LI

Frontiers of Mechanical Engineering 2009, Volume 4, Issue 3,   Pages 300-304 doi: 10.1007/s11465-009-0038-5

Abstract: To construct the spatial kinetic equation of an arterial tube and obtain its radial natural frequencyThe results show that the first-order frequency is 15.8 Hz and the obtained exact analytical solutions

Keywords: spatial kinematics     natural frequency     finite element method    

Dependence of error sensitivity of frequency on bias voltage in force-balanced micro accelerometer

Lili CHEN, Wu ZHOU

Frontiers of Mechanical Engineering 2013, Volume 8, Issue 2,   Pages 146-149 doi: 10.1007/s11465-013-0260-z

Abstract:

To predict more precisely the frequency of force-balanced micro accelerometer with different biasvoltages, the effects of bias voltages on error sensitivity of frequency is studied.The resonance frequency of accelerometer under closed loop control is derived according to its operationsensitivity with designed parameters of structure, circuit and process error can be used to predict the frequency

Keywords: Micro-Electro-Mechanical Systems (MEMS)     micro accelerometer     force-balanced micro accelerometer     frequency    

Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 493-502 doi: 10.1007/s11684-022-0946-x

Abstract: Anaplastic lymphoma kinase (ALK) is the most common fusion gene involved in non-small cell lung cancer (NSCLC), and remarkable response has been achieved with the use of ALK tyrosine kinase inhibitors (ALK-TKIs). However, the clinical efficacy is highly variable. Pre-existing intratumoral heterogeneity (ITH) has been proven to contribute to the poor treatment response and the resistance to targeted therapies. In this work, we investigated whether the variant allele frequencies (VAFs) of ALK fusions can help assess ITH and predict targeted therapy efficacy. Through the application of next-generation sequencing (NGS), 7.2% (326/4548) of patients were detected to be ALK positive. On the basis of the adjusted VAF (adjVAF, VAF normalization for tumor purity) of four different threshold values (adjVAF < 50%, 40%, 30%, or 20%), the association of ALK subclonality with crizotinib efficacy was assessed. Nonetheless, no statistical association was observed between median progression-free survival (PFS) and ALK subclonality assessed by adjVAF, and a poor correlation of adjVAF with PFS was found among the 85 patients who received first-line crizotinib. Results suggest that the ALK VAF determined by hybrid capture-based NGS is probably unreliable for ITH assessment and targeted therapy efficacy prediction in NSCLC.

Keywords: next-generation sequencing     fluorescence in situ hybridization     immunohistochemistry     variant allele frequency    

Title Author Date Type Operation

Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue cultures

Jian Jiao, Na Meng, Hong Wang, Luo Zhang

Journal Article

Case report of neurofibromatosis type 1 combined with primary ciliary dyskinesia

Journal Article

Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients

Journal Article

Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Journal Article

Solid-state transformer-based new traction drive system and control

Jianghua FENG, Jing SHANG, Zhixue ZHANG, Huadong LIU, Zihao HUANG

Journal Article

Improved three-vector based dead-beat model predictive direct power control strategy for grid-connected

Chen-wen CHENG, Heng NIAN, Long-qi LI

Journal Article

A frequency error estimation for isogeometric analysis of Kirchhoff–Love cylindrical shells

Journal Article

Capacity limitation of nuclear units in grid based on analysis of frequency regulation

Yiping DAI, Pan JIANG, Lin GAO, Weimin KAN, Xiaoqing XIAO, Ge JIN

Journal Article

Experimental study of structural damage identification based on modal parameters and decay ratio of acceleration signals

Zhigen WU, Guohua LIU, Zihua ZHANG

Journal Article

Calculation of collision frequency function for aerosol particles in free molecule regime in presence

Xiaowei LUO, Yannick BENICHOU, Suyuan YU

Journal Article

Parameter identification of interconnected power system frequency after trip-out of high voltage transmission

Xuzhan ZHOU,Shanshan LIU,Mingkun WANG,Yiping DAI,Yaohua TANG

Journal Article

Fuel variability effect on flickering frequency of diffusion flames

Jizhao LI, Yang ZHANG

Journal Article

Oscillation frequency of simplified arterial tubes

Hui AN, Fan HE, Lingxia XING, Xiaoyang LI

Journal Article

Dependence of error sensitivity of frequency on bias voltage in force-balanced micro accelerometer

Lili CHEN, Wu ZHOU

Journal Article

Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy

Journal Article