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Clinical acupuncture research in the West

Xianze Meng, Shifen Xu, Lixing Lao

Frontiers of Medicine 2011, Volume 5, Issue 2, Pages 134-140 doi: 10.1007/s11684-011-0135-9

Abstract: acupuncture has rapidly become part of mainstream medicine in the West, where new developments in acupuncture clinicalresearch show extensive progress in evaluating the efficacy and safety of the modality in many categoriesAlthough challenges and difficulties remain, the acupuncture research community has matured and its pastexperience may lead to even better methods and more innovative research.

Keywords： acupuncture clinical research research methodology the West

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Construction of a shared system-based real-world clinical research system

Huikun Wu,Xiaodong Li,Fan Yang,Dan Xie,Hui Li,Jingjing Huang,Mingxing Guo

Frontiers of Medicine 2014, Volume 8, Issue 3, Pages 382-388 doi: 10.1007/s11684-014-0368-5

Abstract:

Hubei Provincial Hospital of Traditional Chinese Medicine established research outpatient clinicsClinical Research Base and to the construction of the National Traditional Chinese Medicine Treatmentand Clinical Research Information Sharing System.With a view of developing a “real-world traditional Chinese medicine clinical research paradigmof clinical research, health management, and characteristics diagnosis and treatment.

Keywords： clinical research shared system real world research outpatient clinic research hospital

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Clinical research of traditional Chinese medicine in big data era

Junhua Zhang,Boli Zhang

Frontiers of Medicine 2014, Volume 8, Issue 3, Pages 321-327 doi: 10.1007/s11684-014-0370-y

Abstract: based on big data, named “The Fourth Paradigm,” has become a new paradigm of scientific researchand genomic data have been accumulated dramatically, which generates big data in medical field for clinicalresearch and assessment.Our research target shifts from the “causality inference” to “correlativity analysisTo conduct clinical studies involved in big data in TCM domain, top level design is needed and should

Keywords： big data traditional Chinese medicine clinical evaluation evidence based medicine

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Experience inheritance from famous specialists based on real-world clinical research paradigm of traditional

Guanli Song,Yinghui Wang,Runshun Zhang,Baoyan Liu,Xuezhong Zhou,Xiaji Zhou,Hong Zhang,Yufeng Guo,Yanxing Xue,Lili Xu

Frontiers of Medicine 2014, Volume 8, Issue 3, Pages 300-309 doi: 10.1007/s11684-014-0357-8

Abstract: clinical research observation, and analysis and data mining via computer and database technologies.The advent of the big data era as well as the formation and practice accumulation of the TCM clinicalresearch paradigm in the real world have provided new perspectives, techniques, and methods for inheritingThrough continuous exploration and practice, the research group proposes the innovation research modebased on the real-world TCM clinical research paradigm, which involves the inheritance and innovation

Keywords： traditional Chinese medicine (TCM) real world clinical research paradigm famous specialist experience

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Scientific computation of big data in real-world clinical research

Guozheng Li,Xuewen Zuo,Baoyan Liu

Frontiers of Medicine 2014, Volume 8, Issue 3, Pages 310-315 doi: 10.1007/s11684-014-0358-7

Abstract: integration of science, technology, and medicine under the guidance of the paradigm of real-world, clinicalscientific research.TCM clinical diagnosis, treatment, and knowledge were traditionally limited to literature and sensationmethods are applied in the modeling and analysis of the various complex relationships in individualized clinicalThus, these methods strongly support the real-world clinical research paradigm of TCM.

Keywords： big data real world clinical research Chinese medicine medical computing

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Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer researchand a new co-clinical model for treatment optimization

Shuyang Sun,Zhiyuan Zhang

Frontiers of Medicine 2016, Volume 10, Issue 1, Pages 104-110 doi: 10.1007/s11684-016-0432-4

Abstract: of their donor tumors have been shown to be the preferred preclinical tool in translational cancer researchestablished and characterized an OSCC PDX panel as part of our tumor bio-bank for translational cancer researchWe also explore the translational value of this well-annotated PDX panel in the development of co-clinical

Keywords： patient-derived xenograft models personalized medicine co-clinical trial patient stratification oral

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Overcoming the challenges of conducting translational research in cell therapy

Sowmya Viswanathan, Armand Keating

Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 333-335 doi: 10.1007/s11684-011-0166-2

Abstract: but despite its considerable impetus, faces numerous challenges including support for translational researchHere, we examine the challenges confronting cell therapy research including the limited funding availablefor translational research partly due to the uncompetitive nature of required validation studies in

Keywords： stem cells clinical trials funding animal models standardization common definitions

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Basic consideration of research strategies for head and neck cancer

Jin Gao, Ben Panizza, Newell W. Johnson, Scott Coman, Alan R. Clough

Frontiers of Medicine 2012, Volume 6, Issue 4, Pages 339-353 doi: 10.1007/s11684-012-0213-7

Abstract: of aetiology, key risk factors related to the development of head and neck cancer, basic features of clinicalWe also suggest basic research strategies on the basis of current knowledge, which should ultimatelylead to the improvement of clinical management.

Keywords： clinical management head and neck cancer prevention and early detection research strategies risk factors

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Clinical data quality problems and countermeasure for real world study

Runshun Zhang,Yinghui Wang,Baoyan Liu,Guangli Song,Xuezhong Zhou,Shizhen Fan,Xishui Pan

Frontiers of Medicine 2014, Volume 8, Issue 3, Pages 352-357 doi: 10.1007/s11684-014-0351-1

Abstract:

Real world study (RWS) has become a hotspot for clinical research.Data quality plays a vital role in research achievement and other clinical research fields.

Keywords： real world study traditional Chinese medicine clinical and research information sharing system data quality

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Ontological reconstruction of the clinical terminology of traditional Chinese medicine

Li Ma,Baoyan Liu,Qi Xie,Shusong Mao,Zhiwei Cui

Frontiers of Medicine 2014, Volume 8, Issue 3, Pages 358-361 doi: 10.1007/s11684-014-0348-9

Abstract:

This study proposes the ontological reconstruction of the current clinical terminology of traditionalof preliminary work related to the said reconstruction, including the ontology-based analysis of TCM clinicalWe conclude that the ontological reconstruction of TCM clinical terminology provides a proper translation

Keywords： ontology traditional Chinese medicine clinical terminology

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune

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The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 527-533 doi: 10.1007/s11684-022-0967-5

Abstract: In this study, we aim to elucidate the clinical impact and long-term course of tricuspid regurgitation

Keywords： orthotopic heart transplant tricuspid regurgitation clinical impact biatrial heart transplantation

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Tianhua Xu, Zitong Sheng, Li Yao

Frontiers of Medicine 2017, Volume 11, Issue 3, Pages 340-348 doi: 10.1007/s11684-017-0570-3

Abstract: A slow increase of subnephrotic proteinuria (<3.5 g/d) is the most common clinical manifestation ofNevertheless, more research is needed to further understand ORG.

Keywords： obesity-related glomerulopathy pathogenesis pathologic clinical characteristics

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Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

Frontiers of Medicine 2020, Volume 14, Issue 2, Pages 126-135 doi: 10.1007/s11684-020-0767-8

Abstract: promising antivirals, convalescent plasma transfusion, and tocilizumab needs to be investigated by ongoing clinical

Keywords： coronavirus disease 2019 epidemiology pathology radiology clinical characteristics treatment

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Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Frontiers of Medicine 2022, Volume 16, Issue 4, Pages 551-573 doi: 10.1007/s11684-022-0928-z

Abstract: Patients with hepatocellular carcinoma (HCC) and bone metastasis (BM) suffer from greatly reduced life quality and a dismal prognosis. However, BM in HCC has long been overlooked possibly due to its relatively low prevalence in previous decades. To date, no consensus or guidelines have been reached or formulated for the prevention and management of HCC BM. Our narrative review manifests the increasing incidence of HCC BM to sound the alarm for additional attention. The risk factors, diagnosis, prognosis, and therapeutic approaches of HCC BM are detailed to provide a panoramic view of this disease to clinicians and specialists. We further delineate an informative cancer bone metastatic cascade based on evidence from recent studies and point out the main factors responsible for the tumor-associated disruption of bone homeostasis and the formation of skeletal cancer lesions. We also present the advances in the pathological and molecular mechanisms of HCC BM to shed light on translational opportunities. Dilemmas and challenges in the treatment and investigation of HCC BM are outlined and discussed to encourage further endeavors in the exploration of underlying pathogenic and molecular mechanisms, as well as the development of novel effective therapies for HCC patients with BM.

Keywords： HCC bone osteotropism clinical basic researches advances

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Title Author Date Type Operation

Clinical acupuncture research in the West

Xianze Meng, Shifen Xu, Lixing Lao

Journal Article

Construction of a shared system-based real-world clinical research system

Huikun Wu,Xiaodong Li,Fan Yang,Dan Xie,Hui Li,Jingjing Huang,Mingxing Guo

Journal Article

Clinical research of traditional Chinese medicine in big data era

Junhua Zhang,Boli Zhang

Journal Article

Experience inheritance from famous specialists based on real-world clinical research paradigm of traditional

Guanli Song,Yinghui Wang,Runshun Zhang,Baoyan Liu,Xuezhong Zhou,Xiaji Zhou,Hong Zhang,Yufeng Guo,Yanxing Xue,Lili Xu

Journal Article

Scientific computation of big data in real-world clinical research

Guozheng Li,Xuewen Zuo,Baoyan Liu

Journal Article

Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer researchand a new co-clinical model for treatment optimization

Shuyang Sun,Zhiyuan Zhang

Journal Article

Overcoming the challenges of conducting translational research in cell therapy

Sowmya Viswanathan, Armand Keating

Journal Article

Basic consideration of research strategies for head and neck cancer

Jin Gao, Ben Panizza, Newell W. Johnson, Scott Coman, Alan R. Clough

Journal Article

Clinical data quality problems and countermeasure for real world study

Runshun Zhang,Yinghui Wang,Baoyan Liu,Guangli Song,Xuezhong Zhou,Shizhen Fan,Xishui Pan

Journal Article

Ontological reconstruction of the clinical terminology of traditional Chinese medicine