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Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 8-27 doi: 10.15302/J-FASE-2018233

Abstract:

Pluripotent stem cells (PSCs) are characterized by their capacity for high self-renewal and multipledifferentiation potential and include embryonic stem cells, embryonic germ cells and induced PSCs.

Keywords: embryonic germ cells     embryonic stem cells     induced pluripotent stem cells     pigs     pluripotent stem cells    

The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 3-7 doi: 10.15302/J-FASE-2018247

Abstract:

Although the pursuit of bovine embryonic stem cells started more than 26 years ago for the purposeof gene-targeting, true pluripotent stem cells in this economically important species are still elusiveneed for pluripotent stem cells for precise genetic modification in any species became questionable.pluripotency circuitry across mammalian species may be the main objective for studying pluripotent stemcells in the bovine.

Keywords: bovine     embryonic     induced     pluripotent stem cells    

Transcriptomics and proteomics in stem cell research

Hai Wang,Qian Zhang,Xiangdong Fang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 433-444 doi: 10.1007/s11684-014-0336-0

Abstract:

Stem cells are capable of self-renewal and differentiation, and the processes regulating these eventscells have been extensively examined.We reviewed the available information on stem cells by examining published results using transcriptomicand proteomic characterization of the different stem cell processes.cell biology and promote the clinical applications of stem cells.

Keywords: embryonic stem cells     transcriptomics     proteomics    

Progress, problems and prospects of porcine pluripotent stem cells

Hanning WANG,Yangli PEI,Ning LI,Jianyong HAN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1,   Pages 6-15 doi: 10.15302/J-FASE-2014009

Abstract: Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced PSCs (iPSCs), can differentiateinto cells of the three germ layers, suggesting that PSCs have great potential for basic developmentalThus, exploration of the unique porcine gene regulation network of preimplantation embryonic development

Keywords: induced pluripotent stem cells     embryonic stem cells     pig     reprogramming    

Regulation and function of histone acetyltransferase MOF

Yang Yang, Xiaofei Han, Jingyun Guan, Xiangzhi Li

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 79-83 doi: 10.1007/s11684-014-0314-6

Abstract: We also analyze the role of MOF as a key regulator of the core transcriptional network of embryonic stemcells.

Keywords: MOF     histone acetyltransferase     DNA damage repair     tumorigenesis     embryonic stem cells    

Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 294-298 doi: 10.1007/s11684-007-0056-9

Abstract: Although all normal tissue cells, including stem cells, are genetically homologous, variation in geneIn normal adults, telomerase activation mainly presents in tissue stem cells and progenitor cells givingand only minorities of cells, designated as cancer stem cells, undergo processes analogous to the self-renewalIn this study, telomerase activity was measured and compared in breast cancer stem cells and non-stemThe results indicated that cancer stem cells show a higher level of enzyme activity than non-stem cells

Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration

Siming Yang, Sha Huang, Changjiang Feng, Xiaobing Fu

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 41-47 doi: 10.1007/s11684-012-0175-9

Abstract:

Umbilical cord mesenchymal stem cells (MSCs) are a unique, accessible, and non-controversial sourceof early stem cells that can be readily manipulated.the most common pluripotent cell, bone marrow-derived MSCs display limitations with the progress of stemBy contrast, umbilical cord-derived cells, which have plentiful resources, are more accessible.

Keywords: umbilical cord     mesenchymal stem cells     cutaneous regeneration    

Mesenchymal stem cells hold promise for regenerative medicine

Shihua Wang, Xuebin Qu, Robert Chunhua Zhao

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 372-378 doi: 10.1007/s11684-011-0164-4

Abstract: an emerging interdisciplinary field of research that uses several technological approaches including stemcells to repair tissues.Mesenchymal stem cells (MSCs), a type of adult stem cell, have generated a great amount of interest overmechanisms through which MSCs exert their therapeutic potential rely on some key properties of the cellsinto osteoblasts, chondrocytes, adipocytes, cardiomyocytes, hepatocytes, endothelial, and neuronal cells

Keywords: mesenchymal stem cells     differentiation     immunomodulation     regenerative medicine    

Highlights for special issue on “Large Animal Stem Cells

Jianyong HAN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 1-2 doi: 10.15302/J-FASE-2019251

Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

Yingchen Li,Guoheng Hu,Qilai Cheng

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 20-29 doi: 10.1007/s11684-014-0371-x

Abstract: As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs

Keywords: cellular therapy     transplantation     human umbilical cord     mesenchymal stem cells     ischemic stroke    

Capacity of human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-likecells: a preclinical study

Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 345-353 doi: 10.1007/s11684-013-0282-2

Abstract:

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) possess various advantageous propertiespotential, multi-lineage differentiation potential and capacity for differentiating into sweat gland-like cellsculture media (ASFCM) in order to determine their potential for differentiation into sweat gland-like cellsMoreover, cells cultured in ASFCM showed vigorous proliferation comparable to those of cells grown inMorphology of hUC-MSCs cultured in ASFCM was comparable to those of cells grown under classical culture

Keywords: umbilical cord     mesenchymal stem cells     sweat gland     preclinical    

Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 28-32 doi: 10.15302/J-FASE-2018222

Abstract:

Primordial germ cells (PGCs) are regarded as unipotent cells that can produce only either spermatogoniaHowever, PGCs can be converted into the pluripotent state by first dedifferentiation to embryonic germcells and then by reprogramming to induce them to become pluripotent stem cells (iPSCs).These two stages can be completely implemented with mouse cells.Here, we discuss recent advances in the stem cell field for obtaining iPSCs from PGCs.

Keywords: pig     pluripotent stem cells     primordial germ cells     reprogramming    

Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic methods

Frontiers of Medicine   Pages 827-858 doi: 10.1007/s11684-022-0948-8

Abstract: Besides routine therapeutic methods, stem cells are rapidly being examined as viable alternative therapiesRemarkable progress has been made in understanding the biology and purpose of stem cells.The affected pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) are further studied forthis study discusses current developments in the use of some kinds of MSCs such as adipose-derived stemcells, bone marrow stromal cells, umbilical cord MSCs, and menstrual blood MSCs.

Keywords: infertility     stem cell therapy     mesenchymal stem cells     pluripotent stem cells    

Identification of cancer stem cells provides novel tumor models for drug discovery

Douglas D. Fang, Danyi Wen, Yajun Xu

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 112-121 doi: 10.1007/s11684-012-0199-1

Abstract:

Cancer stem cells (CSCs) have received considerable attention from the research community since they

Keywords: cancer stem cell     tumor model     drug discovery    

Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study

Ranhua JIANG, Zhibo HAN, Guangsheng ZHUO, Xiaodan QU, Xue LI, Xin WANG, Yuankang SHAO, Shimin YANG, Zhong Chao HAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 94-100 doi: 10.1007/s11684-011-0116-z

Abstract:

Mesenchymal stem cells (MSC) have been used in clinical trials for severe diabetes, a chronic disease

Keywords: placenta stem cells     treatment of type 2 diabetes    

Title Author Date Type Operation

Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Journal Article

The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Journal Article

Transcriptomics and proteomics in stem cell research

Hai Wang,Qian Zhang,Xiangdong Fang

Journal Article

Progress, problems and prospects of porcine pluripotent stem cells

Hanning WANG,Yangli PEI,Ning LI,Jianyong HAN

Journal Article

Regulation and function of histone acetyltransferase MOF

Yang Yang, Xiaofei Han, Jingyun Guan, Xiangzhi Li

Journal Article

Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Journal Article

Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration

Siming Yang, Sha Huang, Changjiang Feng, Xiaobing Fu

Journal Article

Mesenchymal stem cells hold promise for regenerative medicine

Shihua Wang, Xuebin Qu, Robert Chunhua Zhao

Journal Article

Highlights for special issue on “Large Animal Stem Cells

Jianyong HAN

Journal Article

Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

Yingchen Li,Guoheng Hu,Qilai Cheng

Journal Article

Capacity of human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-likecells: a preclinical study

Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu

Journal Article

Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Journal Article

Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic methods

Journal Article

Identification of cancer stem cells provides novel tumor models for drug discovery

Douglas D. Fang, Danyi Wen, Yajun Xu

Journal Article

Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study

Ranhua JIANG, Zhibo HAN, Guangsheng ZHUO, Xiaodan QU, Xue LI, Xin WANG, Yuankang SHAO, Shimin YANG, Zhong Chao HAN

Journal Article