Resource Type

Journal Article 16

Year

2024 1

2022 2

2020 3

2017 1

2015 1

2014 1

2012 1

2011 2

2009 2

2007 2

open ︾

Keywords

angiogenesis 7

Angiogenesis 2

netrin-1 2

tumor 2

3D cell containers 1

3D printing 1

Salmonella VNP20009 1

B16F10 1

Bone regeneration 1

CD34 1

HEK 293 cells 1

Immune microenvironment regulating 1

Interactions 1

Mechanical property enhancement 1

NTDR-IUD 1

Non-contact multicellular coculture 1

Osteogenesis 1

Paracrine effect 1

Polyvinyl alcohol/acrylamide hydrogel 1

open ︾

Search scope:

排序： Display mode:

Correlative investigation of copper/low-density polyethylene nanocomposite on the endometrial angiogenesis

LI Jianxiong, LIU Zilong, DUAN Yonggang, YU Jing, ZHU Changhong, LI Shuang, XIE Changsheng

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 401-404 doi: 10.1007/s11684-007-0078-3

Abstract: was to investigate the effects of copper/low-density polyethylene nanocomposite (nano-Cu/LDPE) on the endometrialangiogenesis in rats, and 100 sexual mature female SD rats were randomly divided into five groups: sham-operationThe results show that Nano-Cu/LDPE have slighter influence on the endometrial angiogenesis than bulk

Keywords： significant difference     female     endometrial angiogenesis     nano-Cu/LDPE     CD34    

HTML PDF Collect

Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 293-304 doi: 10.1007/s11684-019-0715-7

Abstract: Netrin-1, an axon guidance factor, and its receptor UNC5B play important roles in axonal development and angiogenesisand UNC5B expression in kidneys with diabetic kidney disease (DKD) and investigated their roles in angiogenesisindicate that UNC5B antagonizes netrin-1 and that UNC5B upregulation contributes partly to enhancing angiogenesisnetrin-1 and depleting endogenous UNC5B are potential strategies for reducing the incidence of early angiogenesis

Keywords： netrin-1     VEGF-165     UNC5B     angiogenesis     diabetic kidney disease    

HTML PDF Collect

Effects of galectin-3 inhibition on endometrial cell cycle and adhesion

LEI Caixia, ZHANG Wei, SUN Xiaowei, DU Guoping, WANG Li, LIU Yinkun

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 390-397 doi: 10.1007/s11684-007-0076-5

Abstract: In order to investigate the role of gal-3 in the establishment of human endometrial receptivity, theexpression of gal-3 in human endometrial cell line RL95-2 was silenced by RNA interference technologyGal-3 may be involved in the establishment of endometrial receptivity by regulating the proliferationand adhesion of endometrial cells.
HTML PDF Collect

tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 873-882 doi: 10.1007/s11684-022-0925-2

Abstract: Tumor growth is an angiogenesis-dependent process and accompanied by the formation of hypoxic areas.Tumstatin is a tumor-specific angiogenesis inhibitor that suppresses the proliferation and induces thesignificantly inhibited the proliferation and migration of mouse umbilical vascular endothelial cells to impede angiogenesis

Keywords： Salmonella VNP20009     tumstatin     B16F10     melanoma     apoptosis     angiogenesis    

HTML PDF Collect

Influence of new three-dimensional and reticular intrauterine device on the uterine electromyography and endometrial

Wang Leiguang,Guo Chenghao and Qiu Yi

Strategic Study of CAE 2014, Volume 16, Issue 5,   Pages 47-51

Abstract: three-dimensional and reticular intrauterine device (NTDR-IUD) on animal uterine electromyography and endometrial

Keywords： NTDR-IUD     uterine electromyography     endometrial receptivity    

HTML PDF Collect

The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 447-451 doi: 10.1007/s11684-009-0082-x

Abstract: This paper is aimed to examine if changes in platelet-derived growth factor (PDGF) expression at different stages of cervical cancer are related to the variation in blood vessel density (BVD) and lymphatic vessel density (LVD) to evaluate the relationship between PDGF expression and stages and metastasis of cervical cancer. Polymerase chain reaction (PCR) and RT-PCR were used to detect the expression levels of PDGF in 45 cervical cancer tissue samples (the experimental group). The samples were immunohistochemically stained with monoclonal antibodies D2-40 and CD34, and BVD and LVD were measured. The expressions of PDGF-A, -B, and- D were all higher in the experimental group than in the control group (<0.05); no significant difference was found in the expression of PDGF-C between the experimental group and the control group (>0.05). PDGF-A and -B expression was positively related with BVD and LVD (<0.01, R= 0.49, 0.527, 0.327, 0.68). The expression levels of PDGF-C and -D were not significantly related with BVD and LVD. At the early stage of cervical cancer, BVD and LVD were significantly higher than in the controls (<0.01). The BVD and LVD in tissues in the surrounding areas of cervical cancer were significantly higher than in tissues at cancer center, and LVD was related to lymph node metastasis (<0.001). BVD and LVD were not associated with the differentiation and pathological stages of cervical cancer. The expressions of PDGF-A, -B, and -D in cervical cancer were closely related with the clinical stages of cervical cancer. PDGF-A and -B were intimately associated with the lymph node metastasis and prognosis of cervical cancer.

Keywords： cervical cancer     lymphatic vessel density     blood vessel density     platelet-derived growth factor    

HTML PDF Collect

Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives

Bingxue Shang, Zhifei Cao, Quansheng Zhou

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 67-78 doi: 10.1007/s11684-012-0176-8

Abstract:

Antitumor angiogenic therapy has been shown promising in the treatment of several advanced cancers since the approval of the first antiangiogenic drug Avastin in 2004. Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor shrinkage at the early stage of treatment, recent studies have shown that antiangiogenic therapy has transient and insufficient efficacy, resulting in tumor recurrence in patients after several months of treatment. Blockage of blood and oxygen supplies creates a hypoxic and acidic microenvironment in the tumor tissues, which fosters tumor cells to become more aggressive and metastatic. In 2001, Jain proposed tumor vascular normalization as an alternative approach to treating cancers based on the pioneering work on tumor blood vessels by several other researchers. At present, normalizing the disorganized tumor vasculature, rather than disrupting or blocking them, has emerged as a new option for anticancer therapy. Preclinical and clinical data have shown that tumor vascular normalization using monoclonal antibodies, proteins, peptides, small molecules, and pericytes resulted in decreased tumor size and reduced metastasis. However, current tumor vascular normalizing drugs display moderate anticancer efficacy. Accumulated data have shown that a variety of vasculogenic/angiogenic tumor cells and genes play important roles in tumor neovascularization, growth, and metastasis. Therefore, multiple-targeting of vasculogenic tumor cells and genes may improve the efficacy of tumor vascular normalization. To this end, the combination of antiangiogenic drugs with tumor vascular normalizing therapeutics, as well as the integration of Western medicine with traditional Chinese medicine, may provide a good opportunity for discovering novel tumor vascular normalizing drugs for an effective anticancer therapy.

Keywords： angiogenesis     vasculogenesis     neovascularization     tumor     vasculature     normalization     traditional Chinese medicine    

HTML PDF Collect

Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral artery occlusion

Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 86-93 doi: 10.1007/s11684-011-0118-x

Abstract:

Netrin-1 (NT-1) is one of the axon-guiding molecules that are critical for neuronal development. Because of its structural homology to the endothelial mitogens, NT-1 may have similar effects on vascular network formation. NT-1 was shown to be able to stimulate the proliferation and migration of human cerebral endothelial cells in vitro and also promote focal neovascularization in adult brain in vivo. In the present study, we reported the delivery of NT-1 using an adeno-associated virus (AAV) vector (AAV-NT-1) into mouse brain followed by transient middle cerebral artery occlusion (tMCAO). We found that AAV vectors did not elicit a detectable inflammatory response, cell loss or neuronal damage after brain transduction. The level of NT-1 was increased in the AAV-NT-1-transduced tMCAO mice compared with the control mice. Furthermore, the neurobehavioral outcomes were significantly improved in AAV-NT-1-transduced mice compared with the control animals (P<0.05) 7 days after tMCAO. Our data suggests that NT-1 plays a neuronal function recovery role in ischemic brain and that NT-1 gene transfer might present a valuable approach to treat brain ischemic disorders.

Keywords： adeno-associated virus     angiogenesis     gene transfer     ischemia     middle cerebral artery occlusion     netrin-1    

HTML PDF Collect

Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check

Amy Lee, Fa-Chyi Lee

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 273-283 doi: 10.1007/s11684-019-0728-2

Abstract: FDA has approved four oral tyrosine kinase inhibitors, two immune checkpoint inhibitors, and one anti-angiogenesisThe use of immune checkpoint inhibitors in conjunction with oral tyrosine kinase inhibitors or anti-angiogenesis

Keywords： hepatocellular carcinoma     tyrosine kinase inhibitor     check point inhibitor     anti-angiogenesis    

HTML PDF Collect

peritoneal fibrosis in peritoneal dialysis patients: new insights based on peritoneal inflammation and angiogenesis

Zhen Zhang, Na Jiang, Zhaohui Ni

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 349-358 doi: 10.1007/s11684-017-0571-2

Abstract: Inflammation and angiogenesis are key events during the pathogenesis of peritoneal fibrosis.and recent research progress on key fibrogenic molecular mechanisms in peritoneal inflammation and angiogenesisFurthermore, novel strategies targeting peritoneal inflammation and angiogenesis to preserve the PM are

Keywords： peritoneal dialysis     peritoneal fibrosis     inflammation     angiogenesis    

HTML PDF Collect

3D-Printed Scaffolds Promote Angiogenesis by Recruiting Antigen-Specific T Cells Article

Cuidi Li, Zhenjiang Ma, Wentao Li, Tianyang Jie, Liping Zhong, Hongfang Chen, Wenhao Wang, Jinwu Wang, Wenguo Cui, Yongxiang Zhao

Engineering 2022, Volume 17, Issue 10,   Pages 183-195 doi: 10.1016/j.eng.2021.05.018

Abstract: Inspired by the angiogenesis promotion effect of humoral immune response, we covalently combined-- --> T helper 2 (Th2) cells can be recruited to promote early angiogenesis.the proportion of Th2 cells in the spleen and locally recruited antigen-specific T cells to promote angiogenesisThis method may provide a novel concept for patient-specific implant design for angiogenesis promotion

Keywords： 3D printing     Immune microenvironment regulating     Angiogenesis     Bone regeneration    

HTML PDF Collect

Endostatin specifically targets both tumor blood vessels and lymphatic vessels

Wei Zhuo, Yang Chen, Xiaomin Song, Yongzhang Luo

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 336-340 doi: 10.1007/s11684-011-0163-5

Abstract: we briefly summarize recent novel findings, including the functions of endostatin targeting not only angiogenesis

Keywords： endostatin     angiogenesis     lymphangiogenesis     nystatin     internalization     tumor    

HTML PDF Collect

Construction of eukaryotic expression vector of human arresten gene and its secreted expression in HEK 293 cells

Wei LI PhD , Siming GUAN MM , Zifang SONG PhD , Qichang ZHENG PhD , Jun XIONG PhD , Dan SHANG PhD , Xiaogang SHU PhD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 297-302 doi: 10.1007/s11684-009-0058-x

Abstract: The eukaryotic expression vector of human arresten gene was constructed and its secretive expression human embryonic kidney (HEK 293) cells was detected. Human arresten gene was amplified from recombinant plasmid pGEM-Arr by polymerase chain reaction (PCR), and then digested with restriction endonucleases I and I. The target fragment was inserted into the I and I restriction sites of eukaryotic expression vector pSecTag2 to construct pST-AT. Restriction analysis and DNA sequencing indicated that the arresten gene was successfully inserted into pSecTag2. The recombinant plasmid was subsequently transfected into HEK 293 cells with LipofectAMINETM2000 Reagent, and the expression of the target gene was detected. RT-PCR revealed that the mRNA of the target gene was transcribed in the transfected HEK 293 cells. Western Blot analysis verified that the recombinant protein in supernatants was correct. The supernatants of transfected cells were prepared, and 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay was carried out to assess their effect on the proliferation of human umbilical vein endothelial cells, which showed that the recombinant protein could significantly suppress the proliferation of human umbilical vein endothelial cells . These results provided a solid foundation to explore the usage of arresten in tumor anti-angiogenic gene therapy.

Keywords： angiogenesis inhibitor     arresten     eukaryotic expression     HEK 293 cells     endothelial cells    

HTML PDF Collect

Recent Advances in 19Fluorine Magnetic Resonance Imaging with Perfluorocarbon Emulsions Review

Anne H. Schmieder,Shelton D. Caruthers,Jochen Keupp,Samuel A. Wickline,Gregory M. Lanza

Engineering 2015, Volume 1, Issue 4,   Pages 475-489 doi: 10.15302/J-ENG-2015103

Abstract:

The research roots of 19fluorine (19F) magnetic resonance imaging (MRI) date back over 35 years. Over that time span, 1H imaging flourished and was adopted worldwide with an endless array of applications and imaging approaches, making magnetic resonance an indispensable pillar of biomedical diagnostic imaging. For many years during this timeframe, 19F imaging research continued at a slow pace as the various attributes of the technique were explored. However, over the last decade and particularly the last several years, the pace and clinical relevance of 19F imaging has exploded. In part, this is due to advances in MRI instrumentation, 19F/1H coil designs, and ultrafast pulse sequence development for both preclinical and clinical scanners. These achievements, coupled with interest in the molecular imaging of anatomy and physiology, and combined with a cadre of innovative agents, have brought the concept of 19F into early clinical evaluation. In this review, we attempt to provide a slice of this rich history of research and development, with a particular focus on liquid perfluorocarbon compound-based agents.

Keywords： fluorine     magnetic resonance imaging (MRI)     dual-tuned coil     perfluorocarbon     angiogenesis     cell labeling    

HTML PDF Collect

3D Printing of Cell-Container-Like Scaffolds for Multicell Tissue Engineering Article

Xiaoya Wang, Meng Zhang, Jingge Ma, Mengchi Xu, Jiang Chang, Michael Gelinsky, Chengtie Wu

Engineering 2020, Volume 6, Issue 11,   Pages 1276-1284 doi: 10.1016/j.eng.2020.08.001

Abstract: constructed to investigate the individual or synergistic effects of these cells in osteogenesis and angiogenesisand HUVECs revealed that the 3D cell containers with four separate spatial structures enhanced the angiogenesis

Keywords： 3D cell containers     Non-contact multicellular coculture     Interactions     Angiogenesis     Osteogenesis    

HTML PDF Collect

Title Author Date Type Operation

Correlative investigation of copper/low-density polyethylene nanocomposite on the endometrial angiogenesis

LI Jianxiong, LIU Zilong, DUAN Yonggang, YU Jing, ZHU Changhong, LI Shuang, XIE Changsheng

Journal Article

Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Journal Article

Effects of galectin-3 inhibition on endometrial cell cycle and adhesion

LEI Caixia, ZHANG Wei, SUN Xiaowei, DU Guoping, WANG Li, LIU Yinkun

Journal Article

tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis

Journal Article

Influence of new three-dimensional and reticular intrauterine device on the uterine electromyography and endometrial

Wang Leiguang,Guo Chenghao and Qiu Yi

Journal Article

The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

Journal Article

Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives

Bingxue Shang, Zhifei Cao, Quansheng Zhou

Journal Article

Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral artery occlusion

Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG

Journal Article

Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check

Amy Lee, Fa-Chyi Lee

Journal Article

peritoneal fibrosis in peritoneal dialysis patients: new insights based on peritoneal inflammation and angiogenesis

Zhen Zhang, Na Jiang, Zhaohui Ni

Journal Article

3D-Printed Scaffolds Promote Angiogenesis by Recruiting Antigen-Specific T Cells

Cuidi Li, Zhenjiang Ma, Wentao Li, Tianyang Jie, Liping Zhong, Hongfang Chen, Wenhao Wang, Jinwu Wang, Wenguo Cui, Yongxiang Zhao

Journal Article

Endostatin specifically targets both tumor blood vessels and lymphatic vessels

Wei Zhuo, Yang Chen, Xiaomin Song, Yongzhang Luo

Journal Article

Construction of eukaryotic expression vector of human arresten gene and its secreted expression in HEK 293 cells

Wei LI PhD , Siming GUAN MM , Zifang SONG PhD , Qichang ZHENG PhD , Jun XIONG PhD , Dan SHANG PhD , Xiaogang SHU PhD ,

Journal Article

Recent Advances in 19Fluorine Magnetic Resonance Imaging with Perfluorocarbon Emulsions

Anne H. Schmieder,Shelton D. Caruthers,Jochen Keupp,Samuel A. Wickline,Gregory M. Lanza

Journal Article

3D Printing of Cell-Container-Like Scaffolds for Multicell Tissue Engineering

Xiaoya Wang, Meng Zhang, Jingge Ma, Mengchi Xu, Jiang Chang, Michael Gelinsky, Chengtie Wu

Journal Article