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Journal Article 49

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genomic instability 3

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Statistical considerations for genomic selection

Huimin KANG, Lei ZHOU, Jianfeng LIU

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 268-278 doi: 10.15302/J-FASE-2017164

Abstract: Genomic selection is becoming increasingly important in animal and plant breeding, and is attractingthe most commonly used statistical methods and some extensions of them, i.e., ridge regression and genomicIn simulation studies where true breeding values are available, accuracy of genomic estimated breedingFactors influencing the accuracy of genomic selection include linkage disequilibrium between markersGenomic selection has been implemented in the breeding programs of dairy cattle, beef cattle, pigs and

Keywords: genomic estimated breeding value     genomic selection     linkage disequilibrium     statistical methods    

Avoiding the innovation island in infrastructure mega-project

Hongquan CHEN, Quanke SU, Saixing ZENG, Daxin SUN, Jonathan Jingsheng SHI

Frontiers of Engineering Management 2018, Volume 5, Issue 1,   Pages 109-124 doi: 10.15302/J-FEM-2018073

Abstract: We propose a framework to analyze the formation mechanism of the IMP innovation island from three dimensions—theWe look at the Hong Kong-Zhuhai-Macao Bridge project to elaborate the innovation island concept that

Keywords: diversity of innovation bodies     life-cycle dynamics     the unique and temporary nature of IMPs     innovation island    

GLOBAL GENOMIC PREDICTION IN HORTICULTURAL CROPS: PROMISES, PROGRESS, CHALLENGES AND OUTLOOK

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract:

Horticultural crops are a major source of high value nutritious food, and new improved cultivars developed through breeding are required for sustainable production in the face of abiotic and biotic stresses, and to deliver novel, premium products to consumers. However, grower confidence in the performance of new germplasm, particularly across environmental variability, is important for commercial adoption and germplasm-environment matching to optimize production.

Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer

Frontiers of Medicine 2024, Volume 18, Issue 1,   Pages 109-127 doi: 10.1007/s11684-023-1008-8

Abstract: Altered three-dimensional architecture of chromatin influences various genomic regulators and subsequentHowever, knowledge of the topological rearrangement of genomic hierarchical layers in cancer is largely

Keywords: 3D genome     cancer     TADs     loop     gene regulation    

Complete Genome Sequence of Shigella flexneri 2a 301 Strain and Analysis of “Shigella-islands”

Liu Hong,Yang Fan,Zhang Xiaobing,Zhang Jiyu,Yang Guowei,Dong Jie,Xue Ying,Hou Yunde,Yuan Zhenghong,Wen Yumei,Xu Jianguo,Cheng Hongsong,Ma Dalong,Wang Yu,Yang Jian,Shen Yan,Qiang Boqin,Wu Hongtao,Lü Weichuan,Jin Qi

Strategic Study of CAE 2002, Volume 4, Issue 10,   Pages 40-47

Abstract: flexneri 2a strain which isolated from the Beijing outbreak, and the primary analysis of “ Shigella-genomic

Keywords: Shigella flexneri 2a 301 strain     genome sequence     genomic island     pathogenicity island    

GLOBAL GENOMIC PREDICTION IN HORTICULTURAL CROPS: PROMISES, PROGRESS, CHALLENGES AND OUTLOOK

Craig HARDNER, Satish KUMAR, Dorrie MAIN, Cameron PEACE

Frontiers of Agricultural Science and Engineering   Pages 353-355 doi: 10.15302/J-FASE-2021387

Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 57-62 doi: 10.1007/s11684-015-0389-8

Abstract: Our previous research demonstrates that SLCCs are inducible by increasing genomic instability in cancerradicals and is used to protect patients from radioactive exposure, was used as an agent that maintains genomicFurthermore, MMC alone enhanced genomic instability, but MMC combined with AET attenuated the extentof genomic instability in primary VX2 tumor tissue.Taken together, our data suggest that the genomic protector AET can inhibit the induction of SLCCs, and

Keywords: rabbit VX2 liver tumor     mitomycin C     AET     stem-like cancer cells     genomic instability    

Genomic variations in the counterpart normal controls of lung squamous cell carcinomas

Dalin Zhang, Liwei Qu, Bo Zhou, Guizhen Wang, Guangbiao Zhou

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 280-288 doi: 10.1007/s11684-017-0580-1

Abstract: occurrence of LUSC is attributed to exposure to cigarette smoke, which induces the development of numerous genomicHowever, few studies have investigated the genomic variations that occur only in normal tissues thatWe then called genomic variations specific to the normal lung tissues through filtering the genomic sequenceSixteen genomic variations were called in the three normal lung tissues.Our results uncovered previously unreported genomic variations in CNCs, rather than LUSCs, that may be

Keywords: lung cancer     counterpart normal control     genomic variations    

Detection of genomic signatures for pig hairlessness using high-density SNP data

Ying SU,Yi LONG,Xinjun LIAO,Huashui AI,Zhiyan ZHANG,Bin YANG,Shijun XIAO,Jianhong TANG,Wenshui XIN,Lusheng HUANG,Jun REN,Nengshui DING

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 307-313 doi: 10.15302/J-FASE-2014039

Abstract: We conducted a genomic scan for genetically differentiated regions between hairy and hairless pigs usingA total of 38405 SNPs in 498 animals from 36 diverse breeds were used to detect genomic signatures for

Keywords: hairlessness     pig     selective sweeping    

Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Frontiers of Medicine 2023, Volume 17, Issue 6,   Pages 1135-1169 doi: 10.1007/s11684-023-1050-6

Abstract: review endeavors to furnish a holistic insight into pancreatic cancer, encompassing its epidemiology, genomic

Keywords: pancreatic cancer     cancer screening     single cell     molecular alterations     precancerous lesion     therapy resistance    

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Frontiers of Medicine 2023, Volume 17, Issue 5,   Pages 889-906 doi: 10.1007/s11684-023-0994-x

Abstract: Whole-genome sequencing was performed on 68 newly diagnosed Chinese PCNSL samples, whose genomic characteristicsCollectively, this study comprehensively reveals the genomic landscape of newly diagnosed Chinese PCNSLs

Keywords: primary central nervous system lymphoma     whole-genome sequencing     TMSB4X     copy number variation     gene mutation    

Piezoresistive pressure sensor with high sensitivity for medical application using peninsula-island structure

Tingzhong XU, Hongyan WANG, Yong XIA, Zhiming ZHAO, Mimi HUANG, Jiuhong WANG, Libo ZHAO, Yulong ZHAO, Zhuangde JIANG

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 4,   Pages 546-553 doi: 10.1007/s11465-017-0447-9

Abstract: micro-electromechanical systems piezoresistive pressure sensor with a diagonally positioned peninsula-island

Keywords: MEMS     low pressure sensor     peninsula-island     ultra-high sensitivity     medical application    

Cultural differences define diagnosis and genomic medicine practice: implications for undiagnosed diseases

Xiaohong Duan, Thomas Markello, David Adams, Camilo Toro, Cynthia Tifft, William A. Gahl, Cornelius F. Boerkoel

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 389-394 doi: 10.1007/s11684-013-0281-3

Abstract:

Despite the current acceleration and increasing leadership of Chinese genetics research, genetics and its clinical application have largely been imported to China from the Occident. Neither genetics nor the scientific reductionism underpinning its clinical application is integral to the traditional Chinese worldview. Given that disease concepts and their incumbent diagnoses are historically derived and culturally meaningful, we hypothesize that the cultural expectations of genetic diagnoses and medical genetics practice differ between the Occident and China. Specifically, we suggest that an undiagnosed diseases program in China will differ from the recently established Undiagnosed Diseases Program at the United States National Institutes of Health; a culturally sensitive concept will integrate traditional Chinese understanding of disease with the scientific reductionism of Occidental medicine.

Keywords: genetics     cultural differences     undiagnosed diseases program    

Degradation of extracellular genomic, plasmid DNA and specific antibiotic resistance genes by chlorination

Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1124-5

Abstract: itemcontent>

Plasmid DNA/ARGs were less readily broken down than genomic

Keywords: Antibiotic resistance     Antibiotic resistance genes (ARGs)     Extracellular DNA/ARGs     Chlorination    

The Hong Kong–Zhuhai–Macao Island and Tunnel Project

Ming Lin, Wei Lin

Engineering 2017, Volume 3, Issue 6,   Pages 783-784 doi: 10.1016/j.eng.2017.11.003

Title Author Date Type Operation

Statistical considerations for genomic selection

Huimin KANG, Lei ZHOU, Jianfeng LIU

Journal Article

Avoiding the innovation island in infrastructure mega-project

Hongquan CHEN, Quanke SU, Saixing ZENG, Daxin SUN, Jonathan Jingsheng SHI

Journal Article

GLOBAL GENOMIC PREDICTION IN HORTICULTURAL CROPS: PROMISES, PROGRESS, CHALLENGES AND OUTLOOK

Journal Article

Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer

Journal Article

Complete Genome Sequence of Shigella flexneri 2a 301 Strain and Analysis of “Shigella-islands”

Liu Hong,Yang Fan,Zhang Xiaobing,Zhang Jiyu,Yang Guowei,Dong Jie,Xue Ying,Hou Yunde,Yuan Zhenghong,Wen Yumei,Xu Jianguo,Cheng Hongsong,Ma Dalong,Wang Yu,Yang Jian,Shen Yan,Qiang Boqin,Wu Hongtao,Lü Weichuan,Jin Qi

Journal Article

GLOBAL GENOMIC PREDICTION IN HORTICULTURAL CROPS: PROMISES, PROGRESS, CHALLENGES AND OUTLOOK

Craig HARDNER, Satish KUMAR, Dorrie MAIN, Cameron PEACE

Journal Article

Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Journal Article

Genomic variations in the counterpart normal controls of lung squamous cell carcinomas

Dalin Zhang, Liwei Qu, Bo Zhou, Guizhen Wang, Guangbiao Zhou

Journal Article

Detection of genomic signatures for pig hairlessness using high-density SNP data

Ying SU,Yi LONG,Xinjun LIAO,Huashui AI,Zhiyan ZHANG,Bin YANG,Shijun XIAO,Jianhong TANG,Wenshui XIN,Lusheng HUANG,Jun REN,Nengshui DING

Journal Article

Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Journal Article

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Journal Article

Piezoresistive pressure sensor with high sensitivity for medical application using peninsula-island structure

Tingzhong XU, Hongyan WANG, Yong XIA, Zhiming ZHAO, Mimi HUANG, Jiuhong WANG, Libo ZHAO, Yulong ZHAO, Zhuangde JIANG

Journal Article

Cultural differences define diagnosis and genomic medicine practice: implications for undiagnosed diseases

Xiaohong Duan, Thomas Markello, David Adams, Camilo Toro, Cynthia Tifft, William A. Gahl, Cornelius F. Boerkoel

Journal Article

Degradation of extracellular genomic, plasmid DNA and specific antibiotic resistance genes by chlorination

Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden

Journal Article

The Hong Kong–Zhuhai–Macao Island and Tunnel Project

Ming Lin, Wei Lin

Journal Article