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Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

Xiaodong Mo, Xiaojun Huang

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 306-315 doi: 10.1007/s11684-013-0279-x

Abstract:

Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective options forSeveral protocols (with or without ex vivo T-cell depletion (TCD)) have been established worldwide

Keywords： partially matched related donor     hematopoietic stem cell transplantation     allogeneic    

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In vivo imaging of hematopoietic stem cell development in the zebrafish

Panpan Zhang, Feng Liu

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 239-247 doi: 10.1007/s11684-011-0123-0

Abstract: imaging is crucial for developmental biology and can further help to follow cell development/differentiationhas facilitated tracing of the developmental dynamics of a specific organ, tissue, or even a single cellimaging of hematopoiesis due to its transparent embryo at early stage; moreover, different zebrafish hematopoieticstem cells (HSCs) transgenic lines have been demonstrated as very useful tools for illustrating the

Keywords： hematopoietic stem cell     hematopoiesis     in vivo imaging     transgenics     zebrafish    

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Lung transplantation for bronchiolitis obliterans syndrome after allogenic hematopoietic stem cell transplantation

Fei Gao, Jingyu Chen, Dong Wei, Bo Wu, Min Zhou

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 224-228 doi: 10.1007/s11684-017-0538-3

Abstract:

Bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HSCT) is a

Keywords： bronchiolitis obliterans syndrome (BOS)     hematopoietic stem cell transplantation (HSCT)     lung transplantation    

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Risk stratification system for skin and soft tissue infections after allogeneic hematopoietic stem cell

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 957-968 doi: 10.1007/s11684-021-0910-1

Abstract: However, to date, the profiles and clinical outcomes of SSTIs in hematopoietic stem cell transplantation

Keywords： skin and soft tissue infections     hematopoietic stem cell transplantation     risk stratification system    

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Everyone has a donor: contribution of the Chinese experience to global practice of haploidentical hematopoieticstem cell transplantation

Meng Lv, Yingjun Chang, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 45-56 doi: 10.1007/s11684-017-0595-7

Abstract: Human leukocyte antigen (HLA)-matched donors for hematopoietic stem cell transplantation (HSCT) have

Keywords： haploidentical hematopoietic stem cell transplantation     conditioning     graft-versus-host disease     relapse    

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Superiority of allogeneic hematopoietic stem cell transplantation to nilotinib and dasatinib for adult

Lanping Xu,Huanling Zhu,Jianda Hu,Depei Wu,Hao Jiang,Qian Jiang,Xiaojun Huang

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 304-311 doi: 10.1007/s11684-015-0400-4

Abstract: for patients with disease that progressed to accelerated phase following imatinib therapy, allogeneic hematopoieticstem cell transplantation (allo-HSCT) is the only curative therapy.

Keywords： chronic myeloid leukemia     imatinib     dasatinib     nilotinib     allogeneic hematopoietic stem cell transplantation    

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Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 412-420 doi: 10.1007/s11684-015-0423-x

Abstract: mutations provides the first proof-of-principle investigation on the identification of preleukemic stemAlthough DNMT3A mutations alone may only transform hematopoietic stem cells into pre-LSCs without causing

Keywords： preleukemic stem cell     acute myeloid leukemia     relapse     DNMT3A    

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Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

Chuanfeng Wu, Cynthia E. Dunbar

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 356-371 doi: 10.1007/s11684-011-0159-1

Abstract: Virus-based vectors are widely used in hematopoietic stem cell (HSC) gene therapy, and have the abilityintegrate permanently into genomic DNA, thus driving long-term expression of corrective genes in all hematopoieticThis review will summarize current information on the mechanisms of insertional mutagenesis in hematopoieticstem and progenitor cells due to integrating gene transfer vectors, discuss the available assays for

Keywords： gene therapy     hematopoietic stem cells     insertional mutagenesis     genotoxicity     induced pluripotent stem cell    

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Autologous peripheral hematopoietic stem-cell transplantation in a patient with refractory pemphigus

SUN Ledong, SUN Jing, ZENG Kang, MENG Fanyi, DIAO Youtao, XU Dan, HUANG Liang, ZHAO Jie, Liu Qifa

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 191-194 doi: 10.1007/s11684-008-0036-8

Abstract: The aim of this study is to explore the effectiveness of autologous peripheral hematopoietic stem-cellStem-cell mobilization was achieved by treatment with cyclophosphamide, granulocyte colony-stimulatingPeripheral blood stem cells were collected via leukapheresis and cryopreserved for later use.Autologous peripheral hematopoietic stem cell transplantation was followed by reconstitution of the immuneThe patient’s response suggests that autologous peripheral hematopoietic stem cell transplantation may

Keywords： serological activity     leukapheresis     peripheral hematopoietic     cyclophosphamide     resistance    

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Positive stool culture could predict the clinical outcomes of haploidentical hematopoietic stem cell

Lijuan Hu, Qi Wang, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Kaiyan Liu, Hui Wang, Xiaojun Huang, Xiaodong Mo

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 492-503 doi: 10.1007/s11684-019-0681-0

Abstract: effect of positive stool cultures (PSCs) on the clinical outcomes of patients undergoing haploidentical hematopoieticstem cell transplantation (haplo-HSCT) ( = 332).

Keywords： haploidentical     hematopoietic stem cell transplantation     stool culture     Candida    

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Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic hematopoieticstem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 354-364 doi: 10.1007/s11684-018-0665-5

Abstract: investigated in patients with high-risk myelodysplastic syndrome (MDS) who were MRD-positive after allogeneic hematopoieticstem cell transplantation (allo-HSCT).High-risk MDS patients who received non-T-cell-depleted allo-HSCT at the Peking University Institute

Keywords： donor leukocyte infusion     hematopoietic stem cell transplantation     interferon-   

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unsatisfactory response to minimal residual disease-directed donor lymphocyte infusion after allogeneic hematopoieticstem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 238-249 doi: 10.1007/s11684-017-0599-3

Abstract: to MRD-directed DLI and could be a potential salvage treatment for these patients after allogeneic hematopoieticstem cell transplantation.

Keywords： interferon-α     hematopoietic stem cell transplantation     minimal residual disease     donor lymphocyte infusion    

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intravenous busulfan conditioning with post-transplantation cyclophosphamide for allogeneic peripheral stemcell transplantation for adult patients with lymphoid malignancies: a prospective single-arm phase II

Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 108-115 doi: 10.1007/s11684-019-0730-8

Abstract: with other immunosuppressive drugs has emerged as a promising strategy in the setting of allogeneic hematopoieticstem cell transplantation.cyclosporine as graft-versus-host disease (GVHD) prophylaxis after myeloablative conditioning and T cell-repleteperipheral stem cell transplantation in lymphoid malignancies.

Keywords： post-transplantation cyclophosphamide     allogeneic hematopoietic stem cell transplantation     lymphoid malignancies    

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The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 348-355 doi: 10.1007/s11684-011-0150-x

Abstract: Research into the biological properties and clinical potential of stem cells has spurred strong publicapplications of demonstrated safety and efficacy have been developed with the exception of uses of hematopoieticstem cells in the treatment of diseases of the blood and immune systems.cell treatments for an enormously broad range of medical and quality-of-life conditions.In this review, I provide an overview of the global industry in pseudomedical stem cell treatments, with

Keywords： stem cell tourism     medical ethics     stem cell policy and regulation     alternative medicine    

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The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 190-200 doi: 10.1007/s11684-014-0323-5

Abstract:

Over the past few years, several new achievements have been made from stem cell studies, many of whichMoreover, some stem cell-based products have been approved for marketing by different national regulatoryHowever, many critical issues associated mainly with incomplete understanding of stem cell biology andcell regulatory sciences with a goal of promoting the steadfast growth of the well-regulated stem celltherapies abreast of evolvement of stem cell sciences and technologies.

Keywords： stem cell-based medicinal products (SCMPs)     stem cell therapy (SCT)     safety     effectiveness     standards     guidelines    

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Title Author Date Type Operation

Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

Xiaodong Mo, Xiaojun Huang

Journal Article

In vivo imaging of hematopoietic stem cell development in the zebrafish

Panpan Zhang, Feng Liu

Journal Article

Lung transplantation for bronchiolitis obliterans syndrome after allogenic hematopoietic stem cell transplantation

Fei Gao, Jingyu Chen, Dong Wei, Bo Wu, Min Zhou

Journal Article

Risk stratification system for skin and soft tissue infections after allogeneic hematopoietic stem cell

Journal Article

Everyone has a donor: contribution of the Chinese experience to global practice of haploidentical hematopoieticstem cell transplantation

Meng Lv, Yingjun Chang, Xiaojun Huang

Journal Article

Superiority of allogeneic hematopoietic stem cell transplantation to nilotinib and dasatinib for adult

Lanping Xu,Huanling Zhu,Jianda Hu,Depei Wu,Hao Jiang,Qian Jiang,Xiaojun Huang

Journal Article

Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Journal Article

Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

Chuanfeng Wu, Cynthia E. Dunbar

Journal Article

Autologous peripheral hematopoietic stem-cell transplantation in a patient with refractory pemphigus

SUN Ledong, SUN Jing, ZENG Kang, MENG Fanyi, DIAO Youtao, XU Dan, HUANG Liang, ZHAO Jie, Liu Qifa

Journal Article

Positive stool culture could predict the clinical outcomes of haploidentical hematopoietic stem cell

Lijuan Hu, Qi Wang, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Kaiyan Liu, Hui Wang, Xiaojun Huang, Xiaodong Mo

Journal Article

Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic hematopoieticstem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Journal Article

unsatisfactory response to minimal residual disease-directed donor lymphocyte infusion after allogeneic hematopoieticstem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Journal Article

intravenous busulfan conditioning with post-transplantation cyclophosphamide for allogeneic peripheral stemcell transplantation for adult patients with lymphoid malignancies: a prospective single-arm phase II

Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu

Journal Article

The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Journal Article

The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Journal Article