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infertility 2

spermatogenesis 2

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Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism

Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 827-858 doi: 10.1007/s11684-022-0948-8

Abstract: Infertility is experienced by 8%–12% of adults incells (MSCs) are further studied for their possible use in reproductive medicine, particularly for infertilitymanage ovarian and uterine disorders, and each technique presents a novel method for the therapy of infertility

Keywords： infertility stem cell therapy mesenchymal stem cells pluripotent stem cells

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The chromosome breakage rates in 244 cases of the infertility couples

Yu Hongliang,Chang Mingxiu,Cao Henghai,Bo Liwei,Wang Yanli and Wu Yanhong

Strategic Study of CAE 2014, Volume 16, Issue 5, Pages 67-69

Abstract: ">To understand the incidence of chromosome breakage rates for the adverse pregnancy history in the infertilitycouples，we analyzed statistically the chromosomal breakage rates in the infertility couples which havebe one of the important reasons for embryo damage、miscarriage and other the adverse pregnancy in the infertility

Keywords： infertility couples adverse pregnancy chromosome breakage

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Applying TCM Constitution Theory to Infertility via Omics

Qi Wang

Engineering 2023, Volume 30, Issue 11, Pages 30-31 doi: 10.1016/j.eng.2023.05.005

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Immunohistochemical measurement and expression of Mcl-1 in infertile testes

Raafat Hegazy,Abdelmonem Hegazy,Mustafa Ammar,Emad Salem

Frontiers of Medicine 2015, Volume 9, Issue 3, Pages 361-367 doi: 10.1007/s11684-015-0395-x

Abstract:

The diagnosis of azoospermia represents a major challenge to andrologists as this condition may occur despite normal spermatogenesis and genital tracts. Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family of proteins involved in regulation of apoptosis in various cell types. This study aimed to investigate the immunohistochemical expression of Mcl-1 in testicular biopsies of subjects with azoospermia. Eighty-six cases with azoospermia were obtained from 509 infertile patients admitted to the Andrology Unit of the Zagazig University Hospitals from January 2010 to December 2011. Biopsies were diagnosed and classified using H&E-stained slide sections. The specimens were subjected to immunohistochemical staining for Mcl-1 and examined through light microscopy. Forty-five cases of maturation arrest (25 at spermatids and 20 at the spermatocytes), 31 cases of hypospermatogenesis (20 moderate and 11 severe), 5 cases of Sertoli?cell-only syndrome, 2 cases of basement membrane hyalinization, and 1 case of tubular and peritubular sclerosis were observed. Normal spermatogenesis was detected in 2 cases. A strong positive immunoreaction in Leydig cells was observed among all investigated specimens. A moderate reaction was detected in spermatocytes and spermatozoa in cases of normal spermatogenesis and hypospermatogenesis, but a negative reaction was detected in cases of maturation arrest and germ cell aplasia. Apoptosis was found to be associated with decreased rate of spermatogenesis. High apoptosis rates may result in azoospermia, which can occur despite normal spermatogenesis and absence of duct obstruction.

Keywords： spermatogenesis testis Mcl-1 expression immunohistochemical study infertility

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Effects of Medicines and Supplements on Spontaneous Pregnancy and Semen Parameters in Male Infertility Article

Jian Li, Qi Wu, Ernest Hung Yu Ng, Ben Willem J. Mol, Xiao Ke Wu, Chi Chiu Wang

Engineering 2022, Volume 16, Issue 9, Pages 198-209 doi: 10.1016/j.eng.2021.07.009

Abstract: network meta-analysis (NMA) to compare the effectiveness of medicines and supplements for idiopathic male infertilityInfrastructure (CNKI), were searched for the period from January 1990 to June 2021 using the keywords "male infertilityIn conclusion, the optimal treatment for male infertility for live birth is still unknown.

Keywords： Male infertility Medicine Supplement Spontaneous pregnancy rate Sperm parameters

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DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis

Xiuli Zhang, Zhizhou Xia, Xingyu Lv, Donghe Li, Mingzhu Liu, Ruihong Zhang, Tong Ji, Ping Liu, Ruibao Ren

Frontiers of Medicine 2021, Volume 15, Issue 2, Pages 302-312 doi: 10.1007/s11684-021-0851-8

Abstract: Cullin-RING E3 ubiquitin ligase (CRL)-4 is a member of the large CRL family in eukaryotes. It plays important roles in a wide range of cellular processes, organismal development, and physiological and pathological conditions. DDB1- and CUL4-associated factor 8 (DCAF8) is a WD40 repeat-containing protein, which serves as a substrate receptor for CRL4. The physiological role of DCAF8 is unknown. In this study, we constructed knockout mice. Homozygous mice were viable with no noticeable abnormalities. However, the fertility of deficient male mice was markedly impaired, consistent with the high expression of DCAF8 in adult mouse testis. Sperm movement characteristics, including progressive motility, path velocity, progressive velocity, and track speed, were significantly lower in knockout mice than in wild-type (WT) mice. However, the total motility was similar between WT and knockout sperm. More than 40% of spermatids in knockout mice showed pronounced morphological abnormalities with typical bent head malformation. The acrosome and nucleus of knockout sperm looked similar to those of WT sperm. tests showed that the fertilization rate of knockout mice was significantly reduced. The results demonstrated that DCAF8 plays a critical role in spermatogenesis, and DCAF8 is a key component of CRL4 function in the reproductive system.

Keywords： Dcaf8 male infertility spermatogenesis

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Novel Genetic Risk and Metabolic Signatures of Insulin Signaling and Androgenesis in the Anovulation of Polycystic Ovary Syndrome Article

Xiaoke Wu, Chi Chiu Wang, Yijuan Cao, Jian Li, Zhiqiang Li, Hongli Ma, Jingshu Gao, Hui Chang, Duojia Zhang, Jing Cong, Yu Wang, Qi Wu, Xiaoxiao Han, Pui Wah Jacqueline Chung, Yiran Li, Xu Zheng, Lingxi Chen, Lin Zeng, Astrid Borchert, Hartmut Kuhn, Zi-Jiang Chen, Ernest Hung Yu Ng, Elisabet Stener-Victorin, Heping Zhang, Richard S. Legro, Ben Willem J. Mol, Yongyong Shi

Engineering 2023, Volume 23, Issue 4, Pages 103-111 doi: 10.1016/j.eng.2022.08.013

Abstract:

Ovulation induction is a first-line medical treatment for infertility in polycystic ovary syndrome/em>, associated with phenylalanine and arachidonic acid metabolites, contributed to the failure of infertility

Keywords： Polycystic ovary syndrome Infertility Ovulation responses ZNF438 REC114 Whole-exome sequencing