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Expression of heat shock protein gp96 in osteosarcoma and its clinical significance

GUO Weichun, CHEN Anmin

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 200-203 doi: 10.1007/s11684-008-0038-6

Abstract: This study aims to detect the expression of heat shock protein gp96 (HSPgp96) in osteosarcoma and exploreExpression of HSPgp96 in 45 cases of osteosarcoma, including 24 cases of the osteoblast type, 21 casesThe expression rate of HSPgp96 was 100% (45/45) in osteosarcoma, compared with 20% (1/5) in normal boneThe average positive cell rates were 97.23% and 0.48% in osteosarcoma and normal bone tissue, respectivelyThe expression degree of HSPgp96 in osteosarcoma had a clear correlation with the pathologic degree (
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Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 883-895 doi: 10.1007/s11684-022-0919-0

Abstract: Metastasis and drug resistance are the leading causes of poor prognosis in patients with osteosarcomaHere, we reported that autophagy was highly activated in metastatic osteosarcoma.We found increased autophagolysosomes in metastatic osteosarcoma cell lines by using electron microscopyOverall, our findings highlighted the association of autophagy with osteosarcoma progression and shednew light on autophagy-targeting therapy for osteosarcoma.

Keywords： osteosarcoma     autophagy     metastasis     drug resistance     Beclin1     LC3B    

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Knockdown of a Specific Circular Non-coding RNA Significantly Suppresses Osteosarcoma Progression Article

Shidong Wang, Hongliang Zhang, Bo Li, Chenglong Chen, Tingting Ren, Yi Huang, Kai Liu, Jingjing Li, Wei Guo

Engineering 2023, Volume 21, Issue 2,   Pages 187-193 doi: 10.1016/j.eng.2021.12.007

Abstract:

Osteosarcoma (OS) is a malignant mesenchymal tissue tumor known to occur

Keywords： Non-coding RNA     Osteosarcoma     CircRNA     Molecular mechanism     Knockdown    

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Title Author Date Type Operation

Expression of heat shock protein gp96 in osteosarcoma and its clinical significance

GUO Weichun, CHEN Anmin

Journal Article

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma

Journal Article

Knockdown of a Specific Circular Non-coding RNA Significantly Suppresses Osteosarcoma Progression

Shidong Wang, Hongliang Zhang, Bo Li, Chenglong Chen, Tingting Ren, Yi Huang, Kai Liu, Jingjing Li, Wei Guo

Journal Article