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Deubiquitinases as pivotal regulators of T cell functions
Xiao-Dong Yang, Shao-Cong Sun
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 451-462 doi: 10.1007/s11684-018-0651-y
Keywords: deubiquitinase ubiquitination T cell activation T cell differentiation T cell tolerance
Yuting Tan,Han Liu,Saijuan Chen
Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 412-420 doi: 10.1007/s11684-015-0423-x
Genetic mutations are considered to drive the development of acute myeloid leukemia (AML). With the rapid progress in sequencing technologies, many newly reported genes that are recurrently mutated in AML have been found to govern the initiation and relapse of AML. These findings suggest the need to distinguish the driver mutations, especially the most primitive single mutation, from the subsequent passenger mutations. Recent research on DNA methyltransferase 3A (DNMT3A) mutations provides the first proof-of-principle investigation on the identification of preleukemic stem cells (pre-LSCs) in AML patients. Although DNMT3A mutations alone may only transform hematopoietic stem cells into pre-LSCs without causing the full-blown leukemia, the function of this driver mutation appear to persist from AML initiation up to relapse. Therefore, identifying and targeting preleukemic mutations, such as DNMT3A mutations, in AML is a promising strategy for treatment and reduction of relapse risk.
Keywords: preleukemic stem cell acute myeloid leukemia relapse DNMT3A
Arbuscular mycorrhizal associations and the major regulators
Li XUE, Ertao WANG
Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 3, Pages 296-306 doi: 10.15302/J-FASE-2020347
Keywords: AM symbiosis signal regulators nutrients phosphate microbiota
US Regulators Clash Over 5G Rollout and Aircraft Safety
Mitch Leslie
Engineering 2022, Volume 15, Issue 8, Pages 6-8 doi: 10.1016/j.eng.2022.06.002
Title Author Date Type Operation
Deubiquitinases as pivotal regulators of T cell functions
Xiao-Dong Yang, Shao-Cong Sun
Journal Article
Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property
Yuting Tan,Han Liu,Saijuan Chen
Journal Article