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Behavioral methods for the functional assessment of hair cells in zebrafish

Qin Yang, Peng Sun, Shi Chen, Hongzhe Li, Fangyi Chen

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 178-190 doi: 10.1007/s11684-017-0507-x

Abstract: of using zebrafish in auditory research and then introduced three behavioral tests, as follows: the startleresponse, the vestibular-ocular reflex, and rheotaxis.

Keywords： zebrafish (Danio rerio)     behavior     auditory     startle response     vestibular-ocular reflex     rheotaxis    

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Revisiting China’s response to coronavirus disease 2019

Frontiers of Medicine 2023, Volume 17, Issue 6,   Pages 1011-1013 doi: 10.1007/s11684-024-1059-5

Abstract: Revisiting China’s response to coronavirus disease 2019
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Development of a seismic design method based on response spectra for building structures

ZHOU Xiyuan, YU Ruifang

Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 2,   Pages 129-141 doi: 10.1007/s11709-007-0014-2

Abstract: The assumption and problem of the mode-superposition response spectrum method in seismic design codeThe progresses on the mode superposition response spectrum theory are discussed.multiple-support seismic excitations and deducing corresponding method; 4) the approach for calculation of seismic responseof the non-classically damped system with overcritical damping and the calculation method of seismic response

Keywords： generalization     classical damping     mode-superposition response     calculation formula     damping theory    

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Trajectory of COVID-19 response and management strategy in China: scientific rationale driven strategy

Frontiers of Medicine 2024, Volume 18, Issue 1,   Pages 19-30 doi: 10.1007/s11684-024-1074-6

Abstract: China has made extraordinary efforts to this unprecedented pandemic, put its response and control at

Keywords： COVID-19     public health     response and control strategy     science-based policy making    

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Confining pressure effect on dynamic response of high rockfill dam

Xuexing CAO, Yunlong HE, Kun XIONG,

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 1,   Pages 116-126 doi: 10.1007/s11709-010-0014-5

Abstract: A corresponding computational procedure was compiled and applied in the dynamic response analysis of

Keywords： confining pressure effect     high rockfill dam     dynamic response     Hardin-Drnevich constitutive model    

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Coal-based activated carbon prepared by HO activation process for supercapacitors using response surface

Frontiers of Chemical Science and Engineering 2024, Volume 18, Issue 6, doi: 10.1007/s11705-024-2422-4

Abstract: capacitance of coal-based activated carbon prepared by H2O steam activation was studied using the response

Keywords： response surface optimization     coal-based activated carbon     supercapacitor     activating mechanism    

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Topology optimization of transient problem with maximum dynamic response constraint using SOAR scheme

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 3,   Pages 593-606 doi: 10.1007/s11465-021-0636-4

Abstract: method for the continuum topology optimization of transient vibration problem with maximum dynamic responseAn aggregated index in the form of an integral function is presented to cope with the maximum responseThrough comparison with the corresponding static response from the final designs, the optimized results

Keywords： topology optimization     solid isotropic material with penalization     transient response     aggregation function    

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Dynamic response of precast segmental bridge columns under heavy truck impact

Frontiers of Structural and Civil Engineering 2023, Volume 17, Issue 3,   Pages 327-349 doi: 10.1007/s11709-023-0911-z

Abstract: Considering the wide application of precast segmental bridge columns (PSBCs) in engineering practice, impact-resistant performance has gained significant attention. However, few studies have focused on PSBCs subjected to high-energy impacts caused by heavy truck collisions. Therefore, the behavior of PSBCs under a heavy truck impact was investigated in this study using high-fidelity finite element (FE) models. The detailed FE modeling methods of the PSBCs and heavy trucks were validated against experimental tests. The validated modeling methods were employed to simulate collisions between PSBCs and heavy trucks. The simulation results demonstrated that the engine and cargo caused two major peak impact forces during collision. Subsequently, the impact force, failure mode, displacement, and internal force of the PSBCs under heavy truck impacts were scrutinized. An extensive study was performed to assess the influence of the section size, truck weight, impact velocity, and number of precast segments on the impact responses. The truck weight was found to have a minor effect on the engine impact force. Damage was found to be localized at the bottom of the three segments, with the top remaining primarily undamaged. This parametric study demonstrated that larger cross-sections may be a preferred option to protect PSBCs against the impact of heavy trucks.

Keywords： precast segmental bridge columns     heavy truck     collision     dynamic response    

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Dynamic response surface methodology using Lasso regression for organic pharmaceutical synthesis

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 2,   Pages 221-236 doi: 10.1007/s11705-021-2061-y

Abstract: For utilizing such time-resolved data to model the dynamic behavior, dynamic response surface methodology

Keywords： data-driven modeling     pharmaceutical organic synthesis     Lasso regression     dynamic response surface methodology    

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Immune landscape and response to oncolytic virus-based immunotherapy

Frontiers of Medicine 2024, Volume 18, Issue 3,   Pages 411-429 doi: 10.1007/s11684-023-1048-0

Abstract: Oncolytic virus (OV)-based immunotherapy has emerged as a promising strategy for cancer treatment, offering a unique potential to selectively target malignant cells while sparing normal tissues. However, the immunosuppressive nature of tumor microenvironment (TME) poses a substantial hurdle to the development of OVs as effective immunotherapeutic agents, as it restricts the activation and recruitment of immune cells. This review elucidates the potential of OV-based immunotherapy in modulating the immune landscape within the TME to overcome immune resistance and enhance antitumor immune responses. We examine the role of OVs in targeting specific immune cell populations, including dendritic cells, T cells, natural killer cells, and macrophages, and their ability to alter the TME by inhibiting angiogenesis and reducing tumor fibrosis. Additionally, we explore strategies to optimize OV-based drug delivery and improve the efficiency of OV-mediated immunotherapy. In conclusion, this review offers a concise and comprehensive synopsis of the current status and future prospects of OV-based immunotherapy, underscoring its remarkable potential as an effective immunotherapeutic agent for cancer treatment.

Keywords： oncolytic virus     immunotherapy     immunotherapeutic agents     immune landscape    

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Top 10 Influential Events in carbon neutrality and climate change response for 2023

Frontiers in Energy 2024, Volume 18, Issue 1,   Pages 1-3 doi: 10.1007/s11708-024-0934-8

Abstract: Top 10 Influential Events in carbon neutrality and climate change response for 2023

Keywords： Events carbon neutrality    

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Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 816-819 doi: 10.1007/s11684-020-0823-4

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Numerical study on the seismic response of the underground subway station- surrounding soil mass-ground

Guobo WANG, Mingzhi YUAN, Xianfeng MA, Jun WU

Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 4,   Pages 424-435 doi: 10.1007/s11709-016-0381-7

Abstract: In this paper, the seismic response of the Underground subway station-Surrounding soil mass-Ground adjacentdepends on its own dimension, and the presence of underground structure has certain impact on the seismic response

Keywords： underground subway station     ground adjacent building     seismic response    

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Demand response based congestion management in a mix of pool and bilateral electricity market model

Ashwani KUMAR, Charan SEKHAR

Frontiers in Energy 2012, Volume 6, Issue 2,   Pages 164-178 doi: 10.1007/s11708-012-0187-9

Abstract: The nodal prices increases during the congestion hours and the demand response to nodal prices will beIn this paper, demand response-based CM has been proposed for a mix of pool and bilateral electricityMulti-line congestion cases have been considered to study the impact on demand response without and with

Keywords： bid function     congestion management (CM)     demand response     pool+bilateral electricity market     static var    

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Influence of site conditions on seismic design parameters for foundations as determined via nonlinear site response

Muhammad Tariq A. CHAUDHARY

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 1,   Pages 275-303 doi: 10.1007/s11709-021-0685-0

Abstract: conditions, including geotechnical properties and the geological setting, influence the near-surface responseEarthquake Hazards Reduction Program (NEHRP) site classes C and D, through 1D nonlinear seismic site responsePredictive relationships for , , and were derived based on the 1D seismic site response analysis

Keywords： site effects     1D seismic site response analysis     sensitivity analysis     foundations     shear wave velocity     soil    

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Title Author Date Type Operation

Behavioral methods for the functional assessment of hair cells in zebrafish

Qin Yang, Peng Sun, Shi Chen, Hongzhe Li, Fangyi Chen

Journal Article

Revisiting China’s response to coronavirus disease 2019

Journal Article

Development of a seismic design method based on response spectra for building structures

ZHOU Xiyuan, YU Ruifang

Journal Article

Trajectory of COVID-19 response and management strategy in China: scientific rationale driven strategy

Journal Article

Confining pressure effect on dynamic response of high rockfill dam

Xuexing CAO, Yunlong HE, Kun XIONG,

Journal Article

Coal-based activated carbon prepared by HO activation process for supercapacitors using response surface

Journal Article

Topology optimization of transient problem with maximum dynamic response constraint using SOAR scheme

Journal Article

Dynamic response of precast segmental bridge columns under heavy truck impact

Journal Article

Dynamic response surface methodology using Lasso regression for organic pharmaceutical synthesis

Journal Article

Immune landscape and response to oncolytic virus-based immunotherapy

Journal Article

Top 10 Influential Events in carbon neutrality and climate change response for 2023

Journal Article

Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Journal Article

Numerical study on the seismic response of the underground subway station- surrounding soil mass-ground

Guobo WANG, Mingzhi YUAN, Xianfeng MA, Jun WU

Journal Article

Demand response based congestion management in a mix of pool and bilateral electricity market model

Ashwani KUMAR, Charan SEKHAR

Journal Article

Influence of site conditions on seismic design parameters for foundations as determined via nonlinear site response

Muhammad Tariq A. CHAUDHARY

Journal Article