Summary: Soil depletion with absorbed forms of microelements is a realistic problem leading to the formation of many human, plant, animal diseases related with micronutrient deficiencies. Searching for new ways to solve this problem is a crucial for the agro-chemical approach to food production. There are many research papers on plant micronutrient fertilization. However, there is still a lack of systematic review of the literature, which summarizes the most recent knowledge on biofortification of food of plant origin with microelements. This work is a systematic review which presents the various methodologies and compares the results of the applied doses and types of fertilizer formulation with the yield and micronutrient content of edible parts of plants. The PRISMA protocol-based review of the most recent literature data from the last 5 years (2015–2020) concerns enrichment of plants with selenium and iodine. These elements, in contrast to other microelements (zinc, manganese, iron, copper and others) are given to plants most often in anionic form: selenium - SeO, and SeO,, iodine - I, and IO,, making them a separate subgroup of microelements. The review focuses on original research papers (not reviews), collected in 3 popular scientific databases: Scopus, Web of Knowledge, PubMed. This study shows how to effectively cope with hidden hunger taking into account the significance of optimized fertilization. Based on the collected data, the best method of micronutrients administration an integrated fortification strategy for selected trace elements and prospects in research/action development was proposed. It was found that the best way to enrich plants with selenium is foliar fertilization with Se(VI), in increased doses. The effectiveness of fortification is supported by the balanced nutrients fertilization, the presence of microorganisms and selection of plant varieties. Foliar fertilization, in increased doses with iodide (I,) is in turn an effective way to enrich plants with iodine.