阪崎克罗诺杆菌（Cronobacter sakazakii）是一种食源性条件致病菌，可引起坏死性肠炎、脑膜炎和婴儿败血症等危及生命的侵袭性疾病。受该菌污染的婴幼儿配方奶粉（powdered infant formula, PIF）的潜在风险已引起乳品生产商、监管机构和消费者的广泛关注。C. sakazakii 可以在不同食品生产环境和设备表面形成一种保护该菌免受恶劣环境伤害的细胞生长模式——生物膜，并成为其在食品中持续污染的重要来源。然而，细菌生物膜由于其耐药特性难以去除。传统的清洗和消毒程序不足以完全控制生物膜，并且可能会导致进一步的生物膜形成和扩散。因此，基于纳米技术的药物传递系统、物种间相互作用以及制备来自微生物、天然提取物和噬菌体的抗菌分子等控制生物膜的新技术应运而生。本文将重点阐述C. sakazakii 生物膜形成机制及其潜在的控制策略。

Cronobacter sakazakii (C. sakazakii) is a foodborne opportunistic pathogen that can cause life-threatening invasive diseases, such as necrotizing enterocolitis, meningitis, and sepsis in infants. The potential risk of C. sakazakii contamination of powdered infant formula (PIF) is an issue that has attracted considerable attention from manufacturers, regulators, and consumers. C. sakazakii biofilms on the surfaces of equipment and in diverse food-production environments constitute a mode of cell growth that protects the pathogen from hostile environments, and are an important source of persistent contamination of food products. Bacterial biofilms are difficult to remove due to their resistant properties. Conventional cleaning and sterilizing procedures may be insufficient for biofilm control, and may lead to further biofilm development and dispersal. Consequently, novel control strategies are being developed, such as nanotechnology-based delivery systems, interspecies interactions, antimicrobial molecules of microbial origin, natural extracts, and phages. This review focuses on describing the mechanisms underlying the biofilm formation and behavior of C. sakazakii and discussing potential control strategies.