Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine

Ai-Hua Zhang, Hui Sun, Guang-Li Yan, Ying Han, Qi-Qi Zhao, Xi-Jun Wang

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Engineering ›› 2019, Vol. 5 ›› Issue (1) : 60-68. DOI: 10.1016/j.eng.2018.11.008
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Research Traditional Chinese Medicine—Review

Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine

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Abstract

Evaluation of the efficacy of traditional Chinese medicines (TCMs) is an important prerequisite for discovering effective substances, lead compounds, and quality markers (Q markers). At present, there is an urgent need to develop a biological language that can act as abridge for the scientific elaboration of the efficacy of TCMs, and to further highlight the significant value of TCM. Chinese medicinal syndromes and formulae are two essential parts of TCM that directly relate to its efficacy. Syndromes and formulae have been taken as the research objects. The serum pharmacochemistry of the TCM approach with metabolomics were integrated to establish an innovative chinmedomics strategy, which is able to explore syndrome biomarkers and evaluate TCM efficacy in order to discover effective substances from TCMs. A great deal of concrete work in chinmedomics has already performed to bridge the gap between Chinese and Western medicine, and to provide a powerful approach to enhance the scientific value of TCM theory and clinical practice. This article summarizes the application of chinmedomics in identifying the candidate biomarkers of a syndrome and revealing the efficacy of the related formula. We also highlight the discovery of lead compounds and Q markers from TCMs.

Keywords

Chinmedomics / Serum pharmacochemistry of TCM / Efficacy / Metabolomics / Syndrome / Biomarkers / Quality markers

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Ai-Hua Zhang, Hui Sun, Guang-Li Yan, Ying Han, Qi-Qi Zhao, Xi-Jun Wang. Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine. Engineering, 2019, 5(1): 60‒68 https://doi.org/10.1016/j.eng.2018.11.008

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Acknowledgements

This work was supported by grants from the Key Program of National Natural Science Foundation of China (81830110, 81430093, 81373930, 81673586, 81302905, and 81503386), the National Key Subject of Drug Innovation (2015ZX09101043-005 and 2015ZX09101043-011), the TCM State Administration Subject of Public Welfare (2015468004), the University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province (UNPYSCT-2015118), and the Young Talent Lift Engineering Project of China Association of Traditional Chinese Medicine (QNRC2-B06).

Compliance with ethics guidelines

Ai-Hua Zhang, Hui Sun, Guang-Li Yan, Ying Han, Qi-Qi Zhao, and Xi-Jun Wang declare that they have no conflict of interest or financial conflicts to disclose.

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