Food pairing pattern independently associated with cardiometabolic traits beyond dietary indices across eastern and western populations

Qiufeng Deng , Yuhao Sun , Mingxia Gu , Jingxiang Fu , Fengzhe Xu , Yuwen Jiao , Yan Zhou , Beining Ma , Lu Liu , Xiuchao Wang , Quanbin Dong , Tingting Wu , Huayiyang Zou , Jing Shi , Yifeng Wang , Yanhui Sheng , Liming Tang , Wei Sun , An Li , Shixian Hu

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Engineering ›› DOI: 10.1016/j.eng.2025.02.015
Food pairing pattern independently associated with cardiometabolic traits beyond dietary indices across eastern and western populations
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Abstract

Cardiometabolic health is closely linked to diet. Both specific food choices and dietary indices are commonly used to guide cardiometabolic protection strategies. However, the balance between foods may also significantly impact cardiometabolic health.

Keywords

Population study / Dietary foods / Long-term food pairing patterns / Gut microbiome / Cardiometabolic health

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Qiufeng Deng, Yuhao Sun, Mingxia Gu, Jingxiang Fu, Fengzhe Xu, Yuwen Jiao, Yan Zhou, Beining Ma, Lu Liu, Xiuchao Wang, Quanbin Dong, Tingting Wu, Huayiyang Zou, Jing Shi, Yifeng Wang, Yanhui Sheng, Liming Tang, Wei Sun, An Li, Shixian Hu. Food pairing pattern independently associated with cardiometabolic traits beyond dietary indices across eastern and western populations. Engineering DOI:10.1016/j.eng.2025.02.015

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CRediT authorship contribution statement

Qiufeng Deng: Writing – original draft, Visualization, Validation, Formal analysis, Conceptualization. Yuhao Sun: Writing – original draft, Resources, Investigation, Data curation. Mingxia Gu: Writing – original draft, Project administration, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. Jingxiang Fu: Resources, Methodology, Investigation, Funding acquisition, Formal analysis, Data curation, Conceptualization. Fengzhe Xu: Resources, Funding acquisition, Formal analysis, Data curation, Conceptualization. Yuwen Jiao: Resources, Investigation, Formal analysis, Conceptualization. Yan Zhou: Supervision, Resources, Investigation. Beining Ma: Visualization, Validation, Data curation, Conceptualization. Lu Liu: Visualization, Validation, Formal analysis, Data curation, Conceptualization. Xiuchao Wang: Visualization, Validation, Data curation, Conceptualization. Quanbin Dong: Visualization, Validation, Data curation, Conceptualization. Tingting Wu: Methodology, Investigation, Data curation, Conceptualization. Huayiyang Zou: Resources, Investigation, Data curation, Conceptualization. Jing Shi: Supervision, Investigation, Data curation, Conceptualization. Yifeng Wang: Supervision, Resources, Data curation, Conceptualization. Yanhui Sheng: Validation, Supervision, Data curation, Conceptualization. Liming Tang: Supervision, Investigation. Wei Sun: Writing – review & editing, Supervision, Investigation, Funding acquisition, Data curation. An Li: Supervision, Resources, Investigation, Funding acquisition. Shixian Hu: Supervision, Investigation, Funding acquisition. Jusheng Zheng: Investigation, Funding acquisition, Data curation, Conceptualization. Yan He: Supervision, Resources, Investigation. Hongwei Zhou: Writing – review & editing, Supervision, Resources, Funding acquisition, Data curation. Wei Wu: Writing – review & editing, Supervision, Investigation, Funding acquisition, Data curation. Xiangqing Kong: Writing – review & editing, Supervision, Investigation, Data curation. Lianmin Chen: Writing – review & editing, Visualization, Validation, Supervision, Investigation, Data curation, Conceptualization.

Declaration of competing interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Acknowledgments

We thank the participants and staff of the GGMP and NHANES for their collaboration. This project was funded by the National Natural Science Foundation of China (NSFC; 32394052 and 32270077); the Jiangsu Shuangchuang Project (Medical Innovation Team, Medical Expert and JSSCBS20221815); the Natural Science Foundation of Jiangsu (BK20220709); the Nanjing Medical University and Jiangsu Province Hospital (CZ0121002010039, TS202403, YNRCZN0301, CMC2024PY01, and GSKY20210105); the Suzhou Science and Technology Development Plan Foundation (SKY2021010); the Gusu Health Talent Program (GSWS202206); the Development of Jiangsu Higher Education Institutions Priority Academic Program (PAPD). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Data and code availability

The National Health and Nutrition Examination Survey (NHANES) datasets are available in the NHANES repository. The gut microbiome sequencing data of the Guangdong Gut Microbiome Project is deposited at the European Nucleotide Archive with accession number PRJEB18535. The analysis codes are available via: https://github.com/MicrobiomeCardioMetaLab/FoodInteractions_project.

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