Synchronous rectal adenocarcinoma and anal canal adenocarcinoma

2007年第1卷第3期

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《医学前沿（英文）》 >> 2007年第1卷第3期 doi: 10.1007/s11684-007-0064-9

Synchronous rectal adenocarcinoma and anal canal adenocarcinoma

1.Department of Surgery, Beijing Cancer Hospital, Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100036, China; 2.Department of Pathology, Beijing Cancer Hospital, Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100036, China

发布日期： 2007-09-05

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摘要

It is difficult to distinguish a rectal carcinoma with anal metastases from coexistent synchronous anorectal carcinomas. The therapeutic strategy for rectal and anal carcinoma is so different that it should be clearly identified. Here, we report on the case of a 63-year-old man who presented with an upper-third rectal adenocarcinoma. Five months after resection, he developed an adenocarcinoma in the anal canal. The histological slides of both tumors were reviewed and immunohistochemical studies for cytokeratins (CKs) 7 and 20 were performed. The index tumor demonstrated CK 7 /CK 20+ and the second showed CK7+/CK20+. For this reason, we believe the present case had synchronous adenocarcinomas arising from anal canal and the rectum separately. It is very important to differentiate the anorectal lesions pathologically because of the impact on the therapeutic options available, especially for the lesion arising in the anal canal.

关键词

CK7+/CK20+ ; resection ; different ; therapeutic strategy ; upper-third