Protein aggregation in association with delayed neuronal death in rat model of brain ischemia

2008年第2卷第1期

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《医学前沿（英文）》 >> 2008年第2卷第1期 doi: 10.1007/s11684-008-0013-2

Protein aggregation in association with delayed neuronal death in rat model of brain ischemia

1.Department of Neurosurgery, First Hospital of Jilin University; 2.Norman Bethune Medicine School, Jilin University

发布日期： 2008-03-05

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摘要

To investigate the relationship between protein aggregation and delayed neuronal death, we adopted rat models of 20 min ischemia. Brain ischemia was produced using the 2-vessel occlusion (2VO) model in rats Light microscopy, transmission electronic microscopy and Western blot analysis were performed for morphological analysis of neurons, and protein detection. The results showed delayed neuronal death took place at 72 h after ischemia-reperfusion, protein aggregates formed at 4 h after reperfusion and reached the peak at 24 h after reperfusion, and Western blot analysis was consistent with transmission electronic microscopy. We conclude that protein aggregation is one of the important factors leading to delayed neuronal death.