Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis

2009年第3卷第4期

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《医学前沿（英文）》 >> 2009年第3卷第4期 doi: 10.1007/s11684-009-0086-6

Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis

Department of Traditional Chinese Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;

发布日期： 2009-12-05

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摘要

The expression of signal transducer and activator of transcription 6 (STAT6) and nuclear factor-κB (NF-κB) in the colonic mucosa of patients with ulcerative colitis (UC) was examined. Real-time polymerase chain reaction and immunohistochemistry were used to detect the expression of STAT6 and NF-κB p65 at both mRNA and protein levels in the colonic mucosa of patients with UC and healthy volunteers. The results showed that the expression levels of STAT6 and NFκB p65 in the colonic mucosa of patients with UC were significantly higher than in normal controls at both mRNA and protein levels. These data suggest that STAT6 and NFκB p65 perhaps play an important role in the pathogenesis of UC and underscore the potential value of anti-UC strategies in the clinical management of this disease.

关键词

ulcerative colitis ; signal transducer and activator of transcription 6 (STAT6) ; nuclear factor-κ ; B p65 (NF-κ ; B p65)